2QCS
| A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state | Descriptor: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Kim, C, Cheng, C.Y, Saldanha, A.S, Taylor, S.S. | Deposit date: | 2007-06-19 | Release date: | 2007-11-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell(Cambridge,Mass.), 130, 2007
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6I9D
| MloK1 consensus structure from single particle analysis of 2D crystals | Descriptor: | Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION | Authors: | Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H. | Deposit date: | 2018-11-23 | Release date: | 2019-04-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM. Nat Commun, 10, 2019
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6HQ4
| Structure of EAL enzyme Bd1971 - cAMP bound form | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, EAL Enzyme Bd1971, MAGNESIUM ION | Authors: | Lovering, A.L, Cadby, I.T. | Deposit date: | 2018-09-24 | Release date: | 2019-07-31 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase. Embo J., 38, 2019
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6HQ5
| Structure of EAL Enzyme Bd1971 - cAMP and cyclic-di-GMP bound form | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, ... | Authors: | Lovering, A.L, Cadby, I.T. | Deposit date: | 2018-09-24 | Release date: | 2019-07-31 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase. Embo J., 38, 2019
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6HQ7
| Structure of EAL Enzyme Bd1971 - cGMP bound form | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, EAL Enzyme Bd1971, MAGNESIUM ION | Authors: | Lovering, A.L, Cadby, I.T. | Deposit date: | 2018-09-24 | Release date: | 2019-07-31 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase. Embo J., 38, 2019
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6IAX
| MloK1 model from single particle analysis of 2D crystals, class 1 (extended conformation) | Descriptor: | Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION | Authors: | Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H. | Deposit date: | 2018-11-27 | Release date: | 2019-04-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM. Nat Commun, 10, 2019
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3LA7
| Crystal structure of NtcA in apo-form | Descriptor: | Global nitrogen regulator, octyl beta-D-glucopyranoside | Authors: | Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Zhang, C.C, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2010-01-06 | Release date: | 2010-09-01 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc.Natl.Acad.Sci.USA, 107, 2010
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3LA2
| Crystal structure of NtcA in complex with 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, Global nitrogen regulator | Authors: | Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Chen, Y.X, Zhang, C.C, Zhou, C.Z. | Deposit date: | 2010-01-06 | Release date: | 2010-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc.Natl.Acad.Sci.USA, 107, 2010
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6V1X
| Cryo-EM Structure of the Hyperpolarization-Activated Potassium Channel KAT1: Tetramer | Descriptor: | (2S)-1-(nonanoyloxy)-3-(phosphonooxy)propan-2-yl tetradecanoate, (3beta,5beta,14beta,17alpha)-cholestan-3-ol, Potassium channel KAT1 | Authors: | Clark, M.D, Contreras, G.F, Shen, R, Perozo, E. | Deposit date: | 2019-11-21 | Release date: | 2020-06-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Electromechanical coupling in the hyperpolarization-activated K + channel KAT1. Nature, 583, 2020
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6UQF
| Human HCN1 channel in a hyperpolarized conformation | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MERCURY (II) ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Lee, C.-H, MacKinnon, R. | Deposit date: | 2019-10-19 | Release date: | 2019-12-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell, 179, 2019
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3LA3
| Crystal structure of NtcA in complex with 2,2-difluoropentanedioic acid | Descriptor: | 2,2-difluoropentanedioic acid, Global nitrogen regulator | Authors: | Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Chen, Y.X, Zhang, C.C, Zhou, C.Z. | Deposit date: | 2010-01-06 | Release date: | 2010-07-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc.Natl.Acad.Sci.USA, 107, 2010
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6UQG
| Human HCN1 channel Y289D mutant | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Lee, C.-H, MacKinnon, R. | Deposit date: | 2019-10-19 | Release date: | 2019-12-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell, 179, 2019
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6V1Y
| Cryo-EM Structure of the Hyperpolarization-Activated Potassium Channel KAT1: Octamer | Descriptor: | (2S)-1-(nonanoyloxy)-3-(phosphonooxy)propan-2-yl tetradecanoate, (3beta,5beta,14beta,17alpha)-cholestan-3-ol, Potassium channel KAT1 | Authors: | Clark, M.D, Contreras, G.F, Shen, R, Perozo, E. | Deposit date: | 2019-11-21 | Release date: | 2020-06-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Electromechanical coupling in the hyperpolarization-activated K + channel KAT1. Nature, 583, 2020
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6WEK
| Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ... | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | Deposit date: | 2020-04-02 | Release date: | 2020-06-03 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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6VXZ
| SthK P300A cyclic nucleotide-gated potassium channel in the closed state, in complex with cAMP | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Schmidpeter, P.A.M, Rheinberger, J, Nimigean, C.M. | Deposit date: | 2020-02-25 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel. Nat Commun, 11, 2020
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6WJG
| PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | Descriptor: | DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit | Authors: | Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S. | Deposit date: | 2020-04-13 | Release date: | 2020-12-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. Plos Biol., 18, 2020
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6VY0
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6WJF
| PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | Descriptor: | DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit | Authors: | Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S. | Deposit date: | 2020-04-13 | Release date: | 2020-12-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (7.5 Å) | Cite: | Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. Plos Biol., 18, 2020
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6WEL
| Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | Deposit date: | 2020-04-02 | Release date: | 2020-06-03 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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6WEJ
| Structure of cGMP-unbound WT TAX-4 reconstituted in lipid nanodiscs | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | Deposit date: | 2020-04-02 | Release date: | 2020-06-03 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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3MZH
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7YIG
| Human KCNH5 pre-open state 2 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIF
| Human KCNH5 pre-open state 1 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIE
| Human KCNH5-closed state 2 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YID
| Human KCNH5 closed state 1 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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