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6U0P
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BU of 6u0p by Molmil
Crystal structure of PieE, the flavin-dependent monooxygenase involved in the biosynthesis of piericidin A1
Descriptor: 2,4-dichlorophenol 6-monooxygenase, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Shi, R, Manenda, M, Picard, M.-E.
Deposit date:2019-08-14
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations.
J.Biol.Chem., 295, 2020
2QA1
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BU of 2qa1 by Molmil
Crystal structure of PgaE, an aromatic hydroxylase involved in angucycline biosynthesis
Descriptor: 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G.
Deposit date:2007-06-14
Release date:2007-08-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
2QA2
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BU of 2qa2 by Molmil
Crystal structure of CabE, an aromatic hydroxylase from angucycline biosynthesis, determined to 2.7 A resolution
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Polyketide oxygenase CabE
Authors:Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G.
Deposit date:2007-06-14
Release date:2007-08-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
2R0G
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BU of 2r0g by Molmil
Chromopyrrolic acid-soaked RebC with bound 7-carboxy-K252c
Descriptor: 7-carboxy-5-hydroxy-12,13-dihydro-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, FLAVIN-ADENINE DINUCLEOTIDE, RebC
Authors:Ryan, K.S, Drennan, C.L.
Deposit date:2007-08-19
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC
Proc.Natl.Acad.Sci.Usa, 104, 2007
2DKH
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BU of 2dkh by Molmil
Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni, in complex with the substrate
Descriptor: 3-HYDROXYBENZOIC ACID, 3-hydroxybenzoate hydroxylase, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Hiromoto, T, Fujiwara, S, Hosokawa, K, Yamaguchi, H.
Deposit date:2006-04-11
Release date:2006-10-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni has a large tunnel for substrate and oxygen access to the active site
J.Mol.Biol., 364, 2006
2DKI
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BU of 2dki by Molmil
Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni, under pressure of xenon gas (12 atm)
Descriptor: 3-HYDROXYBENZOATE HYDROXYLASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ...
Authors:Hiromoto, T, Fujiwara, S, Hosokawa, K, Yamaguchi, H.
Deposit date:2006-04-11
Release date:2006-10-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni has a large tunnel for substrate and oxygen access to the active site
J.Mol.Biol., 364, 2006
5XGV
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BU of 5xgv by Molmil
The structure of Diels-Alderase PyrE3 in the biosynthetic pathway of pyrroindomycins
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, PyrE3
Authors:Pan, L, Gong, Y, Guo, Y.
Deposit date:2017-04-18
Release date:2018-04-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural Insights into a Flavin-Dependent [4 + 2] Cyclase that Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis.
Cell Chem Biol, 25, 2018
4Z2U
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BU of 4z2u by Molmil
Crystal Structure of 2-hydroxybiphenyl 3-monooxygenase R242Q from Pseudomonas azelaica
Descriptor: 2-hydroxybiphenyl-3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kanteev, M, Bregman-Cohen, A, Fishman, A.
Deposit date:2015-03-30
Release date:2015-08-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism.
Biochim.Biophys.Acta, 1854, 2015
4Z2R
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BU of 4z2r by Molmil
Crystal structure of 2-hydroxybiphenyl 3-monooxygenase from Pseudomonas azelaica
Descriptor: 2-hydroxybiphenyl-3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kanteev, M, Bregman-Cohen, A, Fishman, A.
Deposit date:2015-03-30
Release date:2015-08-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism.
Biochim.Biophys.Acta, 1854, 2015
4Z2T
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BU of 4z2t by Molmil
Crystal Structure of 2-hydroxybiphenyl 3-monooxygenase W225Y from Pseudomonas azelaica
Descriptor: 2-hydroxybiphenyl-3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kanteev, M, Bregman-Cohen, A, Fishman, A.
Deposit date:2015-03-30
Release date:2015-08-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism.
Biochim.Biophys.Acta, 1854, 2015
5BRT
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BU of 5brt by Molmil
Crystal Structure of 2-hydroxybiphenyl 3-monooxygenase from Pseudomonas azelaica with 2-hydroxybiphenyl in the active site
Descriptor: 2-HYDROXYBIPHENYL, 2-hydroxybiphenyl-3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kanteev, M, Bregman-Cohen, A, Deri, B, Adir, N, Fishman, A.
Deposit date:2015-06-01
Release date:2015-08-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism.
Biochim.Biophys.Acta, 1854, 2015
5VQB
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BU of 5vqb by Molmil
Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complex with FAD
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Cox, G, Kelso, J, Stogios, P.J, Savchenko, A, Anderson, W.F, Wright, G.D, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2017-05-08
Release date:2017-08-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.391 Å)
Cite:Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.
Cell Chem Biol, 25, 2018
6EM0
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BU of 6em0 by Molmil
Crystal Structure of 2-hydroxybiphenyl 3-monooxygenase M321A from Pseudomonas azelaica
Descriptor: 2-hydroxybiphenyl-3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Deri, B, Bregman-Cohen, A, Pazy Benhar, Y, Fishman, A.
Deposit date:2017-10-01
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Altering 2-Hydroxybiphenyl 3-Monooxygenase Regioselectivity by Protein Engineering for the Production of a New Antioxidant.
Chembiochem, 19, 2018
4HB9
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BU of 4hb9 by Molmil
Crystal structure of a putative FAD containing monooxygenase from Photorhabdus luminescens subsp. laumondii TTO1 (Target PSI-012791)
Descriptor: 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, Similarities with probable monooxygenase
Authors:Sampathkumar, P, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2012-09-27
Release date:2012-10-17
Last modified:2022-06-15
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Stilbene epoxidation and detoxification in a Photorhabdus luminescens -nematode symbiosis.
J.Biol.Chem., 292, 2017
4ICY
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BU of 4icy by Molmil
Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Kallio, P, Patrikainen, P, Belogurov, G, Mantsala, P, Yang, K, Niemi, J, Metsa-Ketela, M.
Deposit date:2012-12-11
Release date:2013-06-12
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE.
Biochemistry, 52, 2013
4CY6
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BU of 4cy6 by Molmil
apo structure of 2-hydroxybiphenyl 3-monooxygenase HbpA
Descriptor: 2-HYDROXYBIPHENYL-3-MONOOXYGENASE
Authors:Jensen, C.N, Farrugia, J.E, Frank, A, Man, H, Hart, S, Turkenburg, J.P, Grogan, G.
Deposit date:2014-04-10
Release date:2015-03-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structures of the Apo and Fad-Bound Forms of 2-Hydroxybiphenyl 3-Monooxygenase (Hbpa) Locate Activity Hotspots Identified by Using Directed Evolution.
Chembiochem, 16, 2015
4CY8
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BU of 4cy8 by Molmil
2-hydroxybiphenyl 3-monooxygenase (HbpA) in complex with FAD
Descriptor: 2-HYDROXYBIPHENYL 3-MONOOXYGENASE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE
Authors:Jensen, C.N, Farrugia, J.E, Frank, A, Man, H, Hart, S, Turkenburg, J.P, Grogan, G.
Deposit date:2014-04-10
Release date:2015-03-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structures of the Apo and Fad-Bound Forms of 2-Hydroxybiphenyl 3-Monooxygenase (Hbpa) Locate Activity Hotspots Identified by Using Directed Evolution.
Chembiochem, 16, 2015
4EIP
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BU of 4eip by Molmil
Native and K252c bound RebC-10x
Descriptor: 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, FLAVIN-ADENINE DINUCLEOTIDE, Putative FAD-monooxygenase
Authors:Goldman, P.J, Ryan, K.S, Howard-Jones, A.R, Hamill, M.J, Elliott, S.J, Walsh, C.T, Drennan, C.L.
Deposit date:2012-04-05
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.332 Å)
Cite:An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes.
Chem.Biol., 19, 2012
4EIQ
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BU of 4eiq by Molmil
Chromopyrrolic acid-soaked RebC-10x with bound 7-carboxy-K252c
Descriptor: (5S)-7-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5-carboxylic acid, Putative FAD-monooxygenase
Authors:Goldman, P.J, Ryan, K.S, Howard-Jones, A.R, Hamill, M.J, Elliott, S.J, Walsh, C.T, Drennan, C.L.
Deposit date:2012-04-05
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes.
Chem.Biol., 19, 2012
1PN0
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BU of 1pn0 by Molmil
Phenol hydroxylase from Trichosporon cutaneum
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, PHENOL, ...
Authors:Enroth, C.
Deposit date:2003-06-12
Release date:2003-09-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High-resolution structure of phenol hydroxylase and correction of sequence errors.
Acta Crystallogr.,Sect.D, 59, 2003
4K5R
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BU of 4k5r by Molmil
The 2.0 angstrom crystal structure of MTMOIV, a baeyer-villiger monooxygenase from the mithramycin biosynthetic pathway in streptomyces argillaceus.
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Oxygenase
Authors:Noinaj, N, Bosserman, M.A, Rohr, J, Buchanan, S.K.
Deposit date:2013-04-15
Release date:2013-10-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Insight into Substrate Recognition and Catalysis of Baeyer-Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin.
Acs Chem.Biol., 8, 2013
4K5S
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BU of 4k5s by Molmil
The crystal structure of premithramycin B in complex with MTMOIV, a baeyer-villiger monooxygenase from the mithramycin biosynthetic pathway in streptomyces argillaceus.
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Oxygenase, premithramycin B
Authors:Noinaj, N, Bosserman, M.A, Rohr, J, Buchanan, S.K.
Deposit date:2013-04-15
Release date:2013-10-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Insight into Substrate Recognition and Catalysis of Baeyer-Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin.
Acs Chem.Biol., 8, 2013
4K2X
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BU of 4k2x by Molmil
OxyS anhydrotetracycline hydroxylase from Streptomyces rimosus
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Polyketide oxygenase/hydroxylase
Authors:Wang, P, Sawaya, M.R, Tang, Y.
Deposit date:2013-04-09
Release date:2013-05-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Uncovering the Enzymes that Catalyze the Final Steps in Oxytetracycline Biosynthesis.
J.Am.Chem.Soc., 135, 2013
7LO1
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BU of 7lo1 by Molmil
FAD-dependent monooxygenase AfoD from A. nidulans
Descriptor: FAD-dependent monooxygenase afoD, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION
Authors:Rodriguez Benitez, A, Smith, J.L, Narayan, A.R.H.
Deposit date:2021-02-08
Release date:2022-04-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Deciphering the evolution of flavin-dependent monooxygenase stereoselectivity using ancestral sequence reconstruction.
Proc.Natl.Acad.Sci.USA, 120, 2023
4TXI
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BU of 4txi by Molmil
Construct of MICAL-1 containing the monooxygenase and calponin homology domains
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Alqassim, S.S, Amzel, L.M, Bianchet, M.A.
Deposit date:2014-07-03
Release date:2016-01-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.309 Å)
Cite:Modulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights.
Sci Rep, 6, 2016

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