PDB: 14265 resultsInfo pagesStatus searchChemie searchBIRD

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7DXX	Crystal structure of the mk2h_deltaMILPS peptide homodimer Descriptor: MALONIC ACID, mk2h_deltaMILPS protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.403 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXZ	Crystal structure of the chemically synthesized mk2h_deltaMILPYS peptide homodimer in complex with malonate Descriptor: MALONIC ACID, mk2h_deltaMILPYS protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DWW	Crystal structure of the computationally designed msDPBB_sym2 protein Descriptor: msDPBB_sym2 protein Authors: Yagi, S, Schiex, T, Vucinic, J, Barbe, S, Simoncini, D, Tagami, S. Deposit date: 2021-01-18 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.802 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXW	Crystal structure of the mk2h_deltaMIL peptide homodimer Descriptor: SULFATE ION, mk2h_deltaMIL protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.509 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXR	Crystal structure of the mk2h peptide homodimer. Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, SULFATE ION, mk2h protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXT	Crystal structure of the chemically synthesized mk2h peptide homodimer Descriptor: mk2h protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DYC	Crystal structure of the chemically synthesized mk2h_deltaMILPYS peptide homodimer in complex with malate Descriptor: (2S)-2-hydroxybutanedioic acid, D-MALATE, mk2h_deltaMILPYS protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-21 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXV	Crystal structure of the mk2h_deltaY peptide homodimer Descriptor: mk2h_dY protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.301 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXU	Crystal structure of the mk2h_deltaP peptide homodimer Descriptor: SULFATE ION, mk2h_dP protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.314 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
5W1S	X-ray crystal structure of Escherichia coli RNA polymerase and TraR complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-06-04 Release date: 2017-06-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.805 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
7KRN	Structure of SARS-CoV-2 backtracked complex bound to nsp13 helicase - nsp13(1)-BTC Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... Authors: Chen, J, Malone, B, Campbell, E.A, Darst, S.A. Deposit date: 2020-11-20 Release date: 2021-04-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
7KRP	Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - BTC (local refinement) Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHAPSO, MAGNESIUM ION, ... Authors: Chen, J, Malone, B, Campbell, E.A, Darst, S.A. Deposit date: 2020-11-20 Release date: 2021-04-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
7KRO	Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - nsp13(2)-BTC Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... Authors: Chen, J, Malone, B, Campbell, E.A, Darst, S.A. Deposit date: 2020-11-20 Release date: 2021-04-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
3D28	Crystal structure of hcv ns5b polymerase with a novel benzisothiazole inhibitor Descriptor: (5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol-2-one, RNA-directed RNA polymerase Authors: Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. Deposit date: 2008-05-07 Release date: 2009-05-19 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
8GZR	Cryo-EM structure of the the NS5-NS3 RNA-elongation complex Descriptor: CYTIDINE-5'-DIPHOSPHATE, Genome polyprotein, MANGANESE (II) ION, ... Authors: Osawa, T, Ehara, H, Sekine, S. Deposit date: 2022-09-27 Release date: 2023-08-02 Last modified: 2023-08-23 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
2BF0	crystal structure of the rpr of pcf11 Descriptor: CALCIUM ION, PCF11 Authors: Noble, C.G, Hollingworth, D, Martin, S.R, Adeniran, V.E, Smerdon, S.J, Kelly, G, Taylor, I.A, Ramos, A. Deposit date: 2004-12-02 Release date: 2005-01-18 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Key Features of the Interaction between Pcf11 Cid and RNA Polymerase II Ctd. Nat.Struct.Mol.Biol., 12, 2005
5VO8	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V. Deposit date: 2017-05-02 Release date: 2017-05-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.3 Å) Cite: X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3SKH	I. Novel HCV NS5B Polymerase Inhibitors: Discovery of Indole 2- Carboxylic Acids with C3-Heterocycles Descriptor: 1-benzyl-5-chloro-3-(2-fluorophenyl)-1H-indole-2-carboxylic acid, HCV NS5B RNA_DEPENDENT RNA POLYMERASE Authors: Lesburg, C.A, Anilkumar, G.N. Deposit date: 2011-06-22 Release date: 2011-08-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.5 Å) Cite: I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles. Bioorg.Med.Chem.Lett., 21, 2011
7X6S	lymphocytic choriomeningitis virus RNA-dependent RNA polymerase (LCMV-L protein) Descriptor: MANGANESE (II) ION, RNA-directed RNA polymerase L Authors: Liu, L, Lou, Z. Deposit date: 2022-03-08 Release date: 2023-09-13 Last modified: 2023-09-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. Protein Cell, 14, 2023
6WID	Nucleotide incorporation intermediate into quaternary complex of human Polymerase Mu on a complementary DNA double-strand break substrate Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K. Deposit date: 2020-04-09 Release date: 2020-10-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break. Nat Commun, 11, 2020
6WIC	Pre-catalytic quaternary complex of human Polymerase Mu on a complementary DNA double-strand break substrate Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K. Deposit date: 2020-04-09 Release date: 2020-10-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break. Nat Commun, 11, 2020
7ELH	In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state Descriptor: Lambda 1, Minor core protein mu2, PHOSPHATE ION, ... Authors: Zhou, Z.H, Pan, M. Deposit date: 2021-04-11 Release date: 2021-10-20 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor mu2 and capsid proteins. Nat Commun, 12, 2021
3TYQ	SAR development and discovery of potent indole-based inhibitors of the hepatitis c virus NS5B polymerase Descriptor: 5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase Authors: Lesburg, C.A, Chen, K.X. Deposit date: 2011-09-26 Release date: 2012-02-01 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors. J.Med.Chem., 55, 2012
7BJK	Crystal structure of the chloroplastic Fe superoxide dismutase PAP9 from Arabidopsis thaliana. Descriptor: Superoxide dismutase [Fe] 2, chloroplastic, ZINC ION Authors: Cobessi, D, Blanvillain, R, Pfannschmidt, T. Deposit date: 2021-01-14 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.25 Å) Cite: The Plastid-Encoded RNA Polymerase-Associated Protein PAP9 Is a Superoxide Dismutase With Unusual Structural Features. Front Plant Sci, 12, 2021
3U4O	Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides Descriptor: 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase Authors: Anilkumar, G.N, Selyutin, O, Rosenblum, S.B, Zeng, Q, Jiang, Y, Chan, T.-Y, Pu, H, Wang, L, Bennett, F, Chen, K.X, Lesburg, C.A, Duca, J.S, Gavalas, S, Huang, Y, Pinto, P, Sannigrahi, M, Velazquez, F, Venkataraman, S, Vilbubhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Huang, H.-C, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. Deposit date: 2011-10-10 Release date: 2011-12-07 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.77 Å) Cite: II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22, 2012

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