8VU1
| Structure of FabS1CE3-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor (trigonal form) | Descriptor: | S1CE3 VARIANT OF FAB-EPR-1 heavy chain, S1CE3 VARIANT OF FAB-EPR-1 light chain | Authors: | Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. | Deposit date: | 2024-01-27 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
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8W6A
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9BIK
| Crystal structure of inhibitor 1 bound to HPK1 | Descriptor: | (1S,2S)-N-[(6P)-8-amino-6-(4-methylpyridin-3-yl)isoquinolin-3-yl]-2-cyanocyclopropane-1-carboxamide, 1,2-ETHANEDIOL, Mitogen-activated protein kinase kinase kinase kinase 1 | Authors: | Kiefer, J.T, Tellis, J.C, Chan, B.K, Wang, W, Wu, P, Siu, M, Heffron, T.P, Choo, E.F. | Deposit date: | 2024-04-23 | Release date: | 2024-10-02 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1. Acs Med.Chem.Lett., 15, 2024
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9AZ9
| Chloride Sites in Photoactive Yellow Protein (Chloride-Free Reference Structure) | Descriptor: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | Authors: | Dyda, F, Schotte, F, Anfinrud, P, Cho, H.S. | Deposit date: | 2024-03-10 | Release date: | 2024-03-20 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Watching a signaling protein function: What has been learned over four decades of time-resolved studies of photoactive yellow protein. Struct Dyn., 11, 2024
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8C16
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9B9R
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8W6B
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8VM8
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8WIK
| Crystal structure of human FSP1 | Descriptor: | 6-HYDROXY-FLAVIN-ADENINE DINUCLEOTIDE, Ferroptosis suppressor protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Feng, S, Huang, X, Tang, D, Qi, S. | Deposit date: | 2023-09-24 | Release date: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide. MedComm (2020), 5, 2024
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8VTP
| Structure of FabS1CE-EPR-1, a high affinity antibody for the erythropoeitin receptor | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, AMMONIUM ION, ... | Authors: | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sidhu, S.S. | Deposit date: | 2024-01-26 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
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8VVO
| Structure of FabS1CE2-EPR1-1 in complex with the erythropoietin receptor | Descriptor: | CHLORIDE ION, Erythropoietin receptor, S1CE2 VARIANT OF FAB-EPR-1 heavy chain, ... | Authors: | Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. | Deposit date: | 2024-01-31 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
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8OYS
| De novo designed TIM barrel fold TBF_24 | Descriptor: | CHLORIDE ION, De novo designed TIM-barrel | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-08-14 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Computational design of soluble and functional membrane protein analogues. Nature, 631, 2024
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9CZL
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8OYY
| De novo designed soluble GPCR-like fold GLF_32 | Descriptor: | CHLORIDE ION, De novo designed soluble GPCR-like protein, POTASSIUM ION | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-08-14 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Computational design of soluble and functional membrane protein analogues. Nature, 631, 2024
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8Y2T
| Crystal structure of 3C protease from coxsackievirus B3 | Descriptor: | Protease 3C | Authors: | Jiang, H.H, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2024-01-27 | Release date: | 2024-08-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the 3C proteases from Coxsackievirus B3 and B4. Acta Crystallogr.,Sect.F, 80, 2024
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8ZM1
| Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 6 | Descriptor: | (5~{R})-5-propan-2-ylindeno[1,2-b]pyridin-5-ol, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | Authors: | Akai, S, Orita, T, Nomura, A, Adachi, T. | Deposit date: | 2024-05-22 | Release date: | 2024-06-19 | Last modified: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. Bioorg.Med.Chem.Lett., 109, 2024
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9BJ1
| Crystal structure of inhibitor GNE-6893 bound to HPK1 | Descriptor: | (4S,5R,7R,11aP)-10-{[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl}-N~3~-methyl-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide, (9S)-2-{[(6P)-8-amino-6-(5-amino-4-methylpyridin-3-yl)-7-fluoroisoquinolin-3-yl]amino}-6-methyl-5,6-dihydro-4H-pyrazolo[1,5-d][1,4]diazepin-7(8H)-one, 1,2-ETHANEDIOL, ... | Authors: | Kiefer, J.R, Tellis, J.C, Chan, B.K, Wang, W, Wu, P, Choo, E.F, Heffron, T.P, Wei, B, Siu, M. | Deposit date: | 2024-04-24 | Release date: | 2024-10-02 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1. Acs Med.Chem.Lett., 15, 2024
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8OYV
| De novo designed Claudin fold CLF_4 | Descriptor: | De novo designed soluble Claudin | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-08-14 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Computational design of soluble and functional membrane protein analogues. Nature, 631, 2024
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1C5A
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8OYX
| De novo designed soluble GPCR-like fold GLF_18 | Descriptor: | De novo designed soluble GPCR-like protein, PHOSPHATE ION | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-08-14 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Computational design of soluble and functional membrane protein analogues. Nature, 631, 2024
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8VUI
| Structure of FabS1CE-EPR-1, an elbow-locked Fab, in complex with the erythropoeitin receptor | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, ... | Authors: | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sidhu, S.S. | Deposit date: | 2024-01-29 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
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8P1C
| Lysozyme structure solved from serial crystallography data collected at 1 kHz with JUNGFRAU detector at MAXIV | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ... | Authors: | Nan, J, Leonarski, F, Furrer, A, Dworkowski, F. | Deposit date: | 2023-05-11 | Release date: | 2023-10-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Kilohertz serial crystallography with the JUNGFRAU detector at a fourth-generation synchrotron source. Iucrj, 10, 2023
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8OJN
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8W2C
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9BVT
| RNA Pol II - High Mn(+2) concentration | Descriptor: | DNA (5'-D(P*AP*CP*GP*TP*CP*CP*CP*TP*CP*TP*CP*GP*A)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Calero, G. | Deposit date: | 2024-05-20 | Release date: | 2024-10-02 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis of transcription: RNA polymerase II substrate binding and metal coordination using a free-electron laser. Proc.Natl.Acad.Sci.USA, 121, 2024
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