4IEM
| Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+ | Descriptor: | DNA (5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*C)-3'), DNA (5'-D(P*(3DR)P*GP*AP*TP*CP*G)-3'), ... | Authors: | Tsutakawa, S.E, Mol, C.D, Arvai, A.S, Tainer, J.A. | Deposit date: | 2012-12-13 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3936 Å) | Cite: | Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes. J.Biol.Chem., 288, 2013
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6Z45
| CDK9-Cyclin-T1 complex bound by compound 24 | Descriptor: | (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... | Authors: | Ferguson, A, Collie, G.W. | Deposit date: | 2020-05-22 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.37 Å) | Cite: | Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
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4IMY
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1NFI
| I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX | Descriptor: | I-KAPPA-B-ALPHA, NF-KAPPA-B P50, NF-KAPPA-B P65 | Authors: | Jacobs, M.D, Harrison, S.C. | Deposit date: | 1998-08-25 | Release date: | 1998-11-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of an IkappaBalpha/NF-kappaB complex. Cell(Cambridge,Mass.), 95, 1998
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8CCZ
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8CCW
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8CDK
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3BLQ
| Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Cell division protein kinase 9, ... | Authors: | Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. | Deposit date: | 2007-12-11 | Release date: | 2008-07-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
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3BLH
| Crystal Structure of Human CDK9/cyclinT1 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell division protein kinase 9, Cyclin-T1 | Authors: | Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. | Deposit date: | 2007-12-11 | Release date: | 2008-07-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
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9BDX
| NF-kappaB RelA homo-dimer bound to CG-centric kappaB DNA | Descriptor: | DNA (5'-D(*AP*TP*CP*AP*CP*TP*GP*GP*AP*AP*GP*TP*TP*CP*CP*CP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*GP*GP*GP*AP*AP*CP*TP*TP*CP*CP*AP*GP*TP*GP*AP*T)-3'), Transcription factor p65 | Authors: | Biswas, T, Shahabi, S, Tsodikov, O.V, Ghosh, G. | Deposit date: | 2024-04-12 | Release date: | 2024-04-24 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Transient interactions modulate the affinity of NF-kappa B transcription factors for DNA. Proc.Natl.Acad.Sci.USA, 121, 2024
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9BDU
| NF-kappaB RelA homo-dimer bound to AT-centric kappaB DNA | Descriptor: | DNA (5'-D(P*AP*CP*TP*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*AP*GP*TP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*AP*CP*TP*GP*GP*AP*AP*TP*TP*TP*CP*CP*CP*AP*GP*T)-3'), SULFATE ION, ... | Authors: | Biswas, T, Huang, D, Ghosh, G. | Deposit date: | 2024-04-12 | Release date: | 2024-04-24 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Transient interactions modulate the affinity of NF-kappa B transcription factors for DNA. Proc.Natl.Acad.Sci.USA, 121, 2024
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9BDV
| NF-kappaB RelA homo-dimer bound to TA-centric kappaB DNA | Descriptor: | DNA (5'-D(*AP*TP*CP*AP*CP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*GP*TP*GP*AP*T)-3'), SULFATE ION, ... | Authors: | Biswas, T, Shahabi, S, Tsodikov, O.V. | Deposit date: | 2024-04-12 | Release date: | 2024-04-24 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Transient interactions modulate the affinity of NF-kappa B transcription factors for DNA. Proc.Natl.Acad.Sci.USA, 121, 2024
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9BDW
| NF-kappaB RelA homo-dimer bound to GC-centric kappaB DNA | Descriptor: | DNA (5'-D(P*AP*CP*TP*GP*GP*GP*AP*AP*GP*TP*TP*CP*CP*AP*GP*TP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*AP*CP*TP*GP*GP*AP*AP*CP*TP*TP*CP*CP*CP*AP*GP*T)-3'), SULFATE ION, ... | Authors: | Biswas, T, Shahabi, S, Tsodikov, O.V, Huang, D, Ghosh, G. | Deposit date: | 2024-04-12 | Release date: | 2024-04-24 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Transient interactions modulate the affinity of NF-kappa B transcription factors for DNA. Proc.Natl.Acad.Sci.USA, 121, 2024
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6GGR
| Crystal structure of Salmonella zinc metalloprotease effector GtgA in complex with p65 | Descriptor: | Bacteriophage virulence determinant, CHLORIDE ION, Transcription factor p65 | Authors: | Jennings, E, Esposito, D, Rittinger, K, Thurston, T. | Deposit date: | 2018-05-03 | Release date: | 2018-08-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.097 Å) | Cite: | Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-kappa B. J. Biol. Chem., 293, 2018
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2NLL
| RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA | Descriptor: | DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (RETINOIC ACID RECEPTOR), ... | Authors: | Rastinejad, F, Perlmann, T, Evans, R.M, Sigler, P.B. | Deposit date: | 1996-11-20 | Release date: | 1997-03-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature, 375, 1995
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2L6Y
| haddock model of GATA1NF:Lmo2LIM2-Ldb1LID | Descriptor: | Erythroid transcription factor, LIM domain only 2, linker, ... | Authors: | Wilkinson-White, L, Gamsjaeger, R, Dastmalchi, S, Wienert, B, Stokes, P.H, Crossley, M, Mackay, J.P, Matthews, J.M. | Deposit date: | 2010-12-01 | Release date: | 2011-08-31 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1 Proc.Natl.Acad.Sci.USA, 108, 2011
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2ISI
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2GAT
| SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF CHICKEN GATA-1 BOUND TO DNA, NMR, REGULARIZED MEAN STRUCTURE | Descriptor: | DNA (5'-D(*AP*AP*TP*GP*TP*TP*TP*AP*TP*CP*TP*GP*CP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*GP*CP*AP*GP*AP*TP*AP*AP*AP*CP*AP*TP*T)-3'), ERYTHROID TRANSCRIPTION FACTOR GATA-1, ... | Authors: | Clore, G.M, Tjandra, N, Starich, M, Omichinski, J.G, Gronenborn, A.M. | Deposit date: | 1997-11-07 | Release date: | 1998-01-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Use of dipolar 1H-15N and 1H-13C couplings in the structure determination of magnetically oriented macromolecules in solution. Nat.Struct.Biol., 4, 1997
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2KA6
| NMR structure of the CBP-TAZ2/STAT1-TAD complex | Descriptor: | CREB-binding protein, Signal transducer and activator of transcription 1-alpha/beta, ZINC ION | Authors: | Wojciak, J.M, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2008-10-30 | Release date: | 2009-04-07 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains. Embo J., 28, 2009
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1R0N
| Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex | Descriptor: | Ecdsyone Response Element, Ecdysone Response Element, Ecdysone receptor, ... | Authors: | Devarakonda, S, Harp, J.M, Kim, Y, Ozyhar, A, Rastinejad, F. | Deposit date: | 2003-09-22 | Release date: | 2003-10-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the heterodimeric Ecdysone Receptor DNA-binding complex Embo J., 22, 2003
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1TAC
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1E9N
| A second divalent metal ion in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1, and its implications for the catalytic mechanism | Descriptor: | DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE, LEAD (II) ION | Authors: | Beernink, P.T, Segelke, B.W, Rupp, B. | Deposit date: | 2000-10-24 | Release date: | 2001-02-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Two Divalent Metal Ions in the Active Site of a New Crystal Form of Human Apurinic/Apyrimidinic Endonuclease, Ape1: Implications for the Catalytic Mechanism J.Mol.Biol., 307, 2001
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1RAM
| A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA (5'-D(*CP*GP*GP*CP*TP*GP*GP*AP*AP*AP*TP*TP*TP*CP*CP*AP*GP*CP*CP*G)-3'), PROTEIN (TRANSCRIPTION FACTOR NF-KB P65) | Authors: | Chen, Y.-Q, Ghosh, S, Ghosh, G. | Deposit date: | 1997-11-22 | Release date: | 1998-05-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nat.Struct.Biol., 5, 1998
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1RXR
| HIGH RESOLUTION SOLUTION STRUCTURE OF THE RETINOID X RECEPTOR DNA BINDING DOMAIN, NMR, 20 STRUCTURE | Descriptor: | RETINOIC ACID RECEPTOR-ALPHA, ZINC ION | Authors: | Holmbeck, S.M.A, Foster, M.P, Casimiro, D.R, Sem, D.S, Dyson, H.J, Wright, P.E. | Deposit date: | 1998-06-12 | Release date: | 1998-11-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | High-resolution solution structure of the retinoid X receptor DNA-binding domain. J.Mol.Biol., 281, 1998
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1GAT
| SOLUTION STRUCTURE OF THE SPECIFIC DNA COMPLEX OF THE ZINC CONTAINING DNA BINDING DOMAIN OF THE ERYTHROID TRANSCRIPTION FACTOR GATA-1 BY MULTIDIMENSIONAL NMR | Descriptor: | DNA (5'-D(P*AP*GP*AP*TP*AP*AP*AP*C)3'), DNA (5'-D(P*GP*TP*TP*TP*AP*TP*CP*T)-3'), ERYTHROID TRANSCRIPTION FACTOR GATA-1, ... | Authors: | Clore, G.M, Omichinski, J.G, Gronenborn, A.M. | Deposit date: | 1993-06-28 | Release date: | 1993-10-31 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science, 261, 1993
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