8UCT
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![BU of 8uct by Molmil](/molmil-images/mine/8uct) | Crystal structure of TcPINK1 in complex with PRT | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide, SULFATE ION, ... | Authors: | Veyron, S, Rasool, S, Trempe, J.F. | Deposit date: | 2023-09-27 | Release date: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Characterization of a new family of PINK1 inhibitors To Be Published
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7BU4
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![BU of 7bu4 by Molmil](/molmil-images/mine/7bu4) | Crystal structure of CK2a1 complexed with KY49 | Descriptor: | 4-(6-aminocarbonyl-8-oxidanylidene-9-phenyl-7H-purin-2-yl)benzoic acid, Casein Kinase 2 subunit alpha | Authors: | Tsuyuguchi, M, Kinoshita, T. | Deposit date: | 2020-04-04 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.70227313 Å) | Cite: | Design, synthesis and SAR studies of protein kinase CK2 inhibitors with a purine scaffold To Be Published
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8UYF
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![BU of 8uyf by Molmil](/molmil-images/mine/8uyf) | Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer | Descriptor: | Serine/threonine-protein kinase Pink1, mitochondrial | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | Deposit date: | 2023-11-13 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
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8UYH
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![BU of 8uyh by Molmil](/molmil-images/mine/8uyh) | Structure of AMP-PNP-bound Pediculus humanus (Ph) PINK1 dimer | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Pink1, ... | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | Deposit date: | 2023-11-13 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
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8XU4
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![BU of 8xu4 by Molmil](/molmil-images/mine/8xu4) | The Crystal Structure of MAPK2 from Biortus. | Descriptor: | MALONIC ACID, MAP kinase-activated protein kinase 2 | Authors: | Wang, F, Cheng, W, Yuan, Z, Qi, J, Shen, Z. | Deposit date: | 2024-01-12 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | The Crystal Structure of MAPK2 from Biortus. To Be Published
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8XN6
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![BU of 8xn6 by Molmil](/molmil-images/mine/8xn6) | The Crystal Structure of GSK3b from Biortus. | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Glycogen synthase kinase-3 beta, ... | Authors: | Wang, F, Cheng, W, Yuan, Z, Qi, J, Wu, B. | Deposit date: | 2023-12-29 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Crystal Structure of GSK3b from Biortus. To Be Published
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8XPZ
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![BU of 8xpz by Molmil](/molmil-images/mine/8xpz) | The Crystal Structure of TTBK1 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, Tau-tubulin kinase 1 | Authors: | Wang, F, Cheng, W, Yuan, Z, Lin, D, Ni, C. | Deposit date: | 2024-01-04 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Crystal Structure of TTBK1 from Biortus. To Be Published
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8XX1
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![BU of 8xx1 by Molmil](/molmil-images/mine/8xx1) | |
8XEY
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![BU of 8xey by Molmil](/molmil-images/mine/8xey) | The Crystal Structure of C-terminal kinase domain of RSK2 from Biortus | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ribosomal protein S6 kinase alpha-3 | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Zhang, B. | Deposit date: | 2023-12-13 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The Crystal Structure of C-terminal kinase domain of RSK2 from Biortus To Be Published
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8XFY
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![BU of 8xfy by Molmil](/molmil-images/mine/8xfy) | The Crystal Structure of RSK2 from Biortus. | Descriptor: | 2,6-bis(fluoranyl)-4-[4-(4-morpholin-4-ylphenyl)pyridin-3-yl]phenol, Ribosomal protein S6 kinase alpha-3 | Authors: | Wang, F, Cheng, W, Lv, Z, Lin, D, Pan, W. | Deposit date: | 2023-12-14 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The Crystal Structure of RSK2 from Biortus. To Be Published
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8XOV
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![BU of 8xov by Molmil](/molmil-images/mine/8xov) | The Crystal Structure of N-terminal kinase domain of human RSK-1 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Zhang, B. | Deposit date: | 2024-01-02 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The Crystal Structure of N-terminal kinase domain of human RSK-1 from Biortus. To Be Published
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8XN7
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![BU of 8xn7 by Molmil](/molmil-images/mine/8xn7) | Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f | Descriptor: | 5-amino-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-8-(2-(trifluoromethyl)benzyl)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase kinase kinase kinase 1 | Authors: | Huang, W.X, Liu, R, Ding, K. | Deposit date: | 2023-12-29 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur.J.Med.Chem., 269, 2024
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8YHK
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![BU of 8yhk by Molmil](/molmil-images/mine/8yhk) | The Crystal Structure of P21-Activated Kinases Pak4 from Biortus | Descriptor: | Serine/threonine-protein kinase PAK 4, TRIETHYLENE GLYCOL | Authors: | Wang, F, Cheng, W, Lv, Z, Qi, J, Wu, B. | Deposit date: | 2024-02-28 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | The Crystal Structure of P21-Activated Kinases Pak4 from Biortus To Be Published
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9AV6
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![BU of 9av6 by Molmil](/molmil-images/mine/9av6) | |
9AV7
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![BU of 9av7 by Molmil](/molmil-images/mine/9av7) | |
8YHW
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![BU of 8yhw by Molmil](/molmil-images/mine/8yhw) | The Crystal Structure of NF-kB-inducing Kinase (NIK) from Biortus | Descriptor: | 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, MAGNESIUM ION, ... | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. | Deposit date: | 2024-02-28 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The Crystal Structure of NF-kB-inducing Kinase (NIK) from Biortus To Be Published
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8YHL
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![BU of 8yhl by Molmil](/molmil-images/mine/8yhl) | The Crystal Structure of Tgf-Beta Type I Receptor (Alk5) from Biortus | Descriptor: | 1,2-ETHANEDIOL, 2-fluoranyl-~{N}-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1~{H}-imidazol-2-yl]methyl]aniline, ACETATE ION, ... | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. | Deposit date: | 2024-02-28 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | The Crystal Structure of Tgf-Beta Type I Receptor (Alk5) from Biortus To Be Published
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9AY7
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![BU of 9ay7 by Molmil](/molmil-images/mine/9ay7) | Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Quade, B, Huang, X. | Deposit date: | 2024-03-07 | Release date: | 2024-04-17 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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8YGW
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![BU of 8ygw by Molmil](/molmil-images/mine/8ygw) | The Crystal Structure of MAPK11 from Biortus | Descriptor: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Mitogen-activated protein kinase 11 | Authors: | Wang, F, Cheng, W, Yuan, Z, Lin, D, Guo, S. | Deposit date: | 2024-02-27 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.301 Å) | Cite: | The Crystal Structure of MAPK11 from Biortus. To Be Published
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9EPX
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![BU of 9epx by Molmil](/molmil-images/mine/9epx) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3331 | Descriptor: | 1,2-ETHANEDIOL, 7-[(2-chloranyl-1,3-benzothiazol-6-yl)sulfonyl]-~{N}-[(3-chloranyl-4-phenyl-phenyl)methyl]-7-azaspiro[3.5]nonan-2-amine, Casein kinase II subunit alpha, ... | Authors: | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3331 To Be Published
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9EQ0
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![BU of 9eq0 by Molmil](/molmil-images/mine/9eq0) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGJG12 | Descriptor: | Casein kinase II subunit alpha, SULFATE ION, ~{N}-[4-[(3-chloranyl-4-phenyl-phenyl)methylamino]butyl]isoquinoline-5-sulfonamide | Authors: | Kraemer, A, Greco, F, Gerninghaus, J, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGJG12 To Be Published
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9AYA
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![BU of 9aya by Molmil](/molmil-images/mine/9aya) | Crystal structure of CRAF/MEK complex with NST-628 and active RAF dimer | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | Authors: | Quade, B, Huang, X. | Deposit date: | 2024-03-07 | Release date: | 2024-04-17 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9EPV
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![BU of 9epv by Molmil](/molmil-images/mine/9epv) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC333 | Descriptor: | 1,2-ETHANEDIOL, 5-[[2-[(3-chloranyl-4-phenyl-phenyl)methylamino]-7-azaspiro[3.5]nonan-7-yl]sulfonyl]-1,3-dimethyl-benzimidazol-2-one, Casein kinase II subunit alpha, ... | Authors: | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC333 To Be Published
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9EPY
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![BU of 9epy by Molmil](/molmil-images/mine/9epy) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3330 | Descriptor: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... | Authors: | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3330 To Be Published
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9EPZ
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![BU of 9epz by Molmil](/molmil-images/mine/9epz) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3337 | Descriptor: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... | Authors: | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3337 To Be Published
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