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6X50
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BU of 6x50 by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - V state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Llewelyn, E, Chen, J, Kang, J.Y, Darst, S.A.
Deposit date:2020-05-24
Release date:2021-02-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
4RQF
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BU of 4rqf by Molmil
human Seryl-tRNA synthetase dimer complexed with one molecule of tRNAsec
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ...
Authors:Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q.
Deposit date:2014-11-03
Release date:2015-11-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis.
Nucleic Acids Res., 43, 2015
4RQE
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BU of 4rqe by Molmil
human Seryl-tRNA synthetase dimer complexed with two molecules of tRNAsec
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ...
Authors:Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q.
Deposit date:2014-11-03
Release date:2015-11-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (4 Å)
Cite:SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis.
Nucleic Acids Res., 43, 2015
6X2F
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BU of 6x2f by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - L2 state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A.
Deposit date:2020-05-20
Release date:2021-02-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
6X2N
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BU of 6x2n by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - I state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A.
Deposit date:2020-05-20
Release date:2021-02-03
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
6X26
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BU of 6x26 by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - L1 state
Descriptor: DNA (64-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A.
Deposit date:2020-05-20
Release date:2021-02-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
6X4W
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BU of 6x4w by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - III state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A.
Deposit date:2020-05-24
Release date:2021-02-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
6X4Y
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BU of 6x4y by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - IV state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A.
Deposit date:2020-05-24
Release date:2021-02-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
6X43
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BU of 6x43 by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - II state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A.
Deposit date:2020-05-22
Release date:2021-02-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
3TYV
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BU of 3tyv by Molmil
SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase
Descriptor: N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase
Authors:Lesburg, C.A, Chen, K.X.
Deposit date:2011-09-26
Release date:2012-02-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase.
J.Med.Chem., 55, 2012
7AHO
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BU of 7aho by Molmil
RUVBL1-RUVBL2 heterohexameric ring after binding of RNA helicase DHX34
Descriptor: ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2
Authors:Lopez-Perrote, A, Rodriguez, C.F, Llorca, O.
Deposit date:2020-09-25
Release date:2020-11-25
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.
Elife, 9, 2020
7NVX
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BU of 7nvx by Molmil
TFIIH in a post-translocated state (with ADP-BeF3)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CDK-activating kinase assembly factor MAT1, ...
Authors:Aibara, S, Schilbach, S, Cramer, P.
Deposit date:2021-03-16
Release date:2021-05-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
7NVW
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BU of 7nvw by Molmil
TFIIH in a pre-translocated state (without ADP-BeF3)
Descriptor: CDK-activating kinase assembly factor MAT1, General transcription and DNA repair factor IIH helicase subunit XPB, General transcription factor IIE subunit 1, ...
Authors:Aibara, S, Schilbach, S, Cramer, P.
Deposit date:2021-03-16
Release date:2021-05-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
6H9R
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BU of 6h9r by Molmil
Dengue-RdRp3-inhibitor complex soaking
Descriptor: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ...
Authors:Talapatra, S.K, Kozielski, F.
Deposit date:2018-08-05
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.
Biol Open, 8, 2019
6NPW
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BU of 6npw by Molmil
SSu72/Sympk in complex with Ser2/Ser5 phosphorylated peptide
Descriptor: PHOSPHATE ION, Ser2/Ser5 phosphorylated peptide, Ssu72 ortholog, ...
Authors:Irani, S, Zhang, Y.
Deposit date:2019-01-18
Release date:2019-04-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.
J.Biol.Chem., 294, 2019
6H80
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BU of 6h80 by Molmil
Dengue-RdRp3-inhibitor complex co-crystallisation
Descriptor: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ...
Authors:Talapatra, S.K, Kozielski, F.
Deposit date:2018-07-31
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.
Biol Open, 8, 2019
8RE4
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BU of 8re4 by Molmil
Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 5nt pre-translocated complex
Descriptor: DNA (47-MER), DNA (50-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Gao, F, Zhang, X.
Deposit date:2023-12-10
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis of sigma 54 displacement and promoter escape in bacterial transcription.
Proc.Natl.Acad.Sci.USA, 121, 2024
8RED
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BU of 8red by Molmil
Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 8nt complex
Descriptor: DNA (46-MER), DNA (51-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Gao, F, Zhang, X.
Deposit date:2023-12-10
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of sigma 54 displacement and promoter escape in bacterial transcription.
Proc.Natl.Acad.Sci.USA, 121, 2024
8REC
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BU of 8rec by Molmil
Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 7nt complex
Descriptor: DNA (46-MER), DNA (51-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Gao, F, Zhang, X.
Deposit date:2023-12-10
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis of sigma 54 displacement and promoter escape in bacterial transcription.
Proc.Natl.Acad.Sci.USA, 121, 2024
8REE
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BU of 8ree by Molmil
Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 9nt complex
Descriptor: DNA (45-MER), DNA (49-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Gao, F, Zhang, X.
Deposit date:2023-12-10
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of sigma 54 displacement and promoter escape in bacterial transcription.
Proc.Natl.Acad.Sci.USA, 121, 2024
6FLP
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BU of 6flp by Molmil
CryoEM structure of E.coli RNA polymerase paused elongation complex without RNA hairpin bound to NusA
Descriptor: DNA (30-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Guo, X, Weixlbaumer, A.
Deposit date:2018-01-26
Release date:2018-03-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
8KDC
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BU of 8kdc by Molmil
Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in monomeric form
Descriptor: MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ...
Authors:Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S.
Deposit date:2023-08-09
Release date:2024-04-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for dimerization of a paramyxovirus polymerase complex.
Nat Commun, 15, 2024
8KDB
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BU of 8kdb by Molmil
Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form
Descriptor: MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ...
Authors:Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S.
Deposit date:2023-08-09
Release date:2024-04-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for dimerization of a paramyxovirus polymerase complex.
Nat Commun, 15, 2024
8REB
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BU of 8reb by Molmil
Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 6nt complex
Descriptor: DNA (43-MER), DNA (52-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Gao, F, Zhang, X.
Deposit date:2023-12-10
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of sigma 54 displacement and promoter escape in bacterial transcription.
Proc.Natl.Acad.Sci.USA, 121, 2024
8REA
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BU of 8rea by Molmil
Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 5nt post-translocated complex
Descriptor: DNA (44-MER), DNA (51-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Gao, F, Zhang, X.
Deposit date:2023-12-10
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of sigma 54 displacement and promoter escape in bacterial transcription.
Proc.Natl.Acad.Sci.USA, 121, 2024

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