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2A68	Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-07-01 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005
4JK1	X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine tetraphosphate (ppGpp) Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ... Authors: Murakami, K.S. Deposit date: 2013-03-09 Release date: 2013-04-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res., 41, 2013
4JK2	X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp) Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ... Authors: Murakami, K.S. Deposit date: 2013-03-09 Release date: 2013-04-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (4.201 Å) Cite: Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res., 41, 2013
4KI2	Crystallographic analysis of an RNA-polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA Descriptor: DNA (5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3'), POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2013-05-01 Release date: 2013-09-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystallographic analysis of an RNA polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes. Acta Crystallogr.,Sect.F, 69, 2013
2A6H	Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Temiakov, D, Zenkin, N, Vassylyeva, M.N, Perederina, A, Tahirov, T.H, Savkina, M, Zorov, S, Nikiforov, V, Igarashi, N, Matsugaki, N, Wakatsuki, S, Severinov, K, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-07-02 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis of transcription inhibition by antibiotic streptolydigin. Mol.Cell, 19, 2005
2A69	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-07-02 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005
2BE5	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-10-22 Release date: 2005-11-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for transcription inhibition by tagetitoxin Nat.Struct.Mol.Biol., 12, 2005
7KHE	Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp Descriptor: CHAPSO, DNA (46-MER), DNA (54-MER), ... Authors: Shin, Y, Qayyum, M.Z, Murakami, K.S. Deposit date: 2020-10-21 Release date: 2020-12-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
7KHB	Escherichia coli RNA polymerase and rrnBP1 promoter open complex Descriptor: CHAPSO, DNA (60-MER), DNA (64-MER), ... Authors: Shin, Y, Qayyum, M.Z, Murakami, K.S. Deposit date: 2020-10-20 Release date: 2020-10-28 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
7KHC	Escherichia coli RNA polymerase and rrnBP1 promoter closed complex Descriptor: CHAPSO, DNA (18 MER), DNA (63-MER), ... Authors: Shin, Y, Qayyum, M.Z, Murakami, K.S. Deposit date: 2020-10-20 Release date: 2020-10-28 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.14 Å) Cite: Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
7KHI	Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp Descriptor: CHAPSO, DNA (28-MER), DNA (36-MER), ... Authors: Shin, Y, Qayyum, M.Z, Murakami, K.S. Deposit date: 2020-10-21 Release date: 2020-10-28 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.62 Å) Cite: Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
7KIN	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter Descriptor: DNA (49-MER), DNA (54-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2020-10-23 Release date: 2021-04-21 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.74 Å) Cite: Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
7KIM	Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription factor Descriptor: DNA (45-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2020-10-23 Release date: 2021-04-21 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
7KIF	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription factor Descriptor: DNA (55-MER), DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2020-10-23 Release date: 2021-04-21 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
8VJL	SpoIVFB:pro-sigmaK complex Descriptor: DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, Lauryl Maltose Neopentyl Glycol, RNA polymerase sigma factor, ... Authors: Orlando, M.A, Pouillon, H.J.T, Mandal, S, Kroos, L, Orlando, B.J. Deposit date: 2024-01-07 Release date: 2024-10-02 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Substrate engagement by the intramembrane metalloprotease SpoIVFB. Nat Commun, 15, 2024
8VJM	SpoIVFB(E44Q variant):pro-sigmaK complex Descriptor: DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, Lauryl Maltose Neopentyl Glycol, RNA polymerase sigma-K factor, ... Authors: Orlando, M.A, Pouillon, H.J.T, Mandal, S, Kroos, L, Orlando, B.J. Deposit date: 2024-01-07 Release date: 2024-10-02 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (4 Å) Cite: Substrate engagement by the intramembrane metalloprotease SpoIVFB. Nat Commun, 15, 2024
8X6G	Cryo-EM structure of Staphylococcus aureus sigB-dependent RNAP-promoter open complex Descriptor: DNA (70-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yuan, L, Xu, L, Liu, Q, Feng, Y. Deposit date: 2023-11-21 Release date: 2024-06-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase. Nat Commun, 15, 2024
8X6F	Cryo-EM structure of Staphylococcus aureus sigA-dependent RNAP-promoter open complex Descriptor: DNA (71-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yuan, L, Xu, L, Liu, Q, Feng, Y. Deposit date: 2023-11-21 Release date: 2024-06-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase. Nat Commun, 15, 2024
8W8N	Thermus thermophilus initiation transcription complex in the pre-translocated state Descriptor: DNA (21-MER), DNA (27-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2023-09-04 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (2.693 Å) Cite: Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
8W8P	Thermus thermophilus initiation transcription complex containing CMPcPP in the post-translocated state Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (21-MER), DNA (27-MER), ... Authors: Li, L, Zhang, Y. Deposit date: 2023-09-04 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (3.165 Å) Cite: Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
8W8O	Thermus thermophilus initiation complex in the half-translocated state Descriptor: DNA (21-MER), DNA (27-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2023-09-04 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (2.512 Å) Cite: Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
8Y6U	Cryo-EM structure of E.coli transcription initiation complex with transcription factor GcvA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Shi, J. Deposit date: 2024-02-03 Release date: 2024-06-05 Method: ELECTRON MICROSCOPY (3.97 Å) Cite: NMR analysis of a loop-bulge structure of UUCGA pentaloop. Biochem.Biophys.Res.Commun., 691, 2024
8Z6G	the AlgU-MucAcyto complex structure in Pseudomonas aeruginosa Descriptor: Anti sigma-E RseA, N-terminal domain protein, RNA polymerase sigma factor Authors: Li, T, Wang, Y.Z, Bao, R. Deposit date: 2024-04-19 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (2.10109687 Å) Cite: the AlgU-MucAcyto complex structure in Pseudomonas aeruginosa To Be Published
7L7B	Clostridioides difficile RNAP with fidaxomicin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. Deposit date: 2020-12-28 Release date: 2022-02-02 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.26 Å) Cite: Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604, 2022
7MLB	Crystal structure of Thermus thermophilus transcription initiation complex with 5nt RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*AP*GP*GP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*CP*AP*TP*CP*CP*CP*TP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022

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