PDB: 12119 resultsInfo pagesStatus searchChemie searchBIRD

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7VTW	Crystal structure of PDE8A catalytic domain in complex with 17 Descriptor: 2-chloro-9-(3-(2,2-difluoroethoxy)-5-isopropoxybenzyl)-9H-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... Authors: Wu, X.-N, Zhou, Q, Huang, Y.-D, Li, Z, Wu, Y, Luo, H.-B. Deposit date: 2021-10-31 Release date: 2022-11-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.79971337 Å) Cite: Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia To Be Published
7XMK	Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923 Descriptor: 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 Authors: Zhang, L, Wang, Y, Li, Y, Yang, S. Deposit date: 2022-04-26 Release date: 2023-04-26 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2.376 Å) Cite: From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases. J.Med.Chem., 67, 2024
2ATM	Crystal structure of the recombinant allergen Ves v 2 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hyaluronoglucosaminidase, SULFATE ION Authors: Skov, L.K, Seppala, U, Coen, J.J.F, Crickmore, N, King, T.P, Monsalve, R, Kastrup, J.S, Spangfort, M.D, Gajhede, M. Deposit date: 2005-08-25 Release date: 2006-05-23 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom. Acta Crystallogr.,Sect.D, 62, 2006
4ATM	Crystal structure of the BAR domain of human Amphiphysin, isoform 1 at 1.8 Angstrom resolution featuring increased order at the N- terminus. Descriptor: 1,2-ETHANEDIOL, AMPHIPHYSIN, GLYCEROL Authors: Allerston, C.K, Krojer, T, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, von Delft, F, Gileadi, O. Deposit date: 2012-05-08 Release date: 2012-05-30 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.783 Å) Cite: Crystal Structure of the Bar Domain of Human Amphiphysin, Isoform 1 To be Published
3ATM	Crystal structure of trypsin complexed with 2-(1H-indol-3-yl)ethanamine Descriptor: 2-(1H-INDOL-3-YL)ETHANAMINE, CALCIUM ION, Cationic trypsin, ... Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2011-01-05 Release date: 2011-08-24 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.72 Å) Cite: In-crystal affinity ranking of fragment hit compounds reveals a relationship with their inhibitory activities J.Appl.Crystallogr., 44, 2011
8ATM	Structure of the giant inhibitor of apoptosis, BIRC6 (composite map) Descriptor: Baculoviral IAP repeat-containing protein 6 Authors: Dietz, L, Elliott, P.R. Deposit date: 2022-08-23 Release date: 2023-03-08 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Science, 379, 2023
7ATM	Structure of P. aeruginosa PBP3 in complex with a phenyl boronic acid (Compound 1) Descriptor: (3-(1H-tetrazol-5-yl)phenyl)boronic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Newman, H, Bellini, B, Dowson, C.G. Deposit date: 2020-10-30 Release date: 2021-08-11 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.582 Å) Cite: High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes. J.Med.Chem., 64, 2021
8ATO	Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC Descriptor: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein Authors: Dietz, L, Elliott, P.R. Deposit date: 2022-08-23 Release date: 2023-03-08 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Science, 379, 2023
6ATM	Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox Descriptor: Potassium channel toxin alpha-KTx 3.10 Authors: Gewe, M.M, Rupert, P, Strong, R.K. Deposit date: 2017-08-29 Release date: 2018-08-22 Last modified: 2019-11-06 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox To Be Published
4U36	Crystal structure of a seed lectin from Vatairea macrocarpa complexed with Tn-antigen Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, CALCIUM ION, CITRIC ACID, ... Authors: Sousa, B.L, Silva-Filho, J.C, Kumar, P, Lyskowski, A, Bezerra, G.A, Delatorre, P, Rocha, B.A.M, Nagano, C.S, Gruber, K, Cavada, B.S. Deposit date: 2014-07-18 Release date: 2014-12-31 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: High-resolution structure of a new Tn antigen-binding lectin from Vatairea macrocarpa and a comparative analysis of Tn-binding legume lectins. Int.J.Biochem.Cell Biol., 59C, 2014
8SKR	human liver mitochondrial Aspartate aminotransferase Descriptor: Aspartate aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE Authors: Zhang, Z, Tringides, M. Deposit date: 2023-04-20 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (2.99 Å) Cite: High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology. Mol.Cell Proteomics, 22, 2023
1MAP	CRYSTAL STRUCTURES OF TRUE ENZYMATIC REACTION INTERMEDIATES: ASPARTATE AND GLUTAMATE KETIMINES IN ASPARTATE AMINOTRANSFERASE Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYLENE)-AMINO]-SUCCINIC ACID, ASPARTATE AMINOTRANSFERASE Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1993-09-10 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structures of true enzymatic reaction intermediates: aspartate and glutamate ketimines in aspartate aminotransferase. Biochemistry, 32, 1993
1MAQ	CRYSTAL STRUCTURES OF TRUE ENZYMATIC REACTION INTERMEDIATES: ASPARTATE AND GLUTAMATE KETIMINES IN ASPARTATE AMINOTRANSFERASE Descriptor: ASPARTATE AMINOTRANSFERASE, N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1993-09-10 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structures of true enzymatic reaction intermediates: aspartate and glutamate ketimines in aspartate aminotransferase. Biochemistry, 32, 1993
4U2A	Structure of a lectin from the seeds of Vatairea macrocarpa complexed with GalNAc Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, CALCIUM ION, CITRIC ACID, ... Authors: Sousa, B.L, Silva-Filho, J.C, Kumar, P, Lyskowski, A, Bezerra, G.A, Delatorre, P, Rocha, B.A.M, Nagano, C.S, Gruber, K, Cavada, B.S. Deposit date: 2014-07-16 Release date: 2014-12-31 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.74 Å) Cite: High-resolution structure of a new Tn antigen-binding lectin from Vatairea macrocarpa and a comparative analysis of Tn-binding legume lectins. Int.J.Biochem.Cell Biol., 59C, 2014
9JDW	CRYSTAL STRUCTURE OF HUMAN L-ARGININE:GLYCINE AMIDINOTRANSFERASE IN COMPLEX WITH ALPHA-AMINO BUTYRIC ACID Descriptor: ALPHA-AMINOBUTYRIC ACID, PROTEIN (L-ARGININE:GLYCINE AMIDINOTRANSFERASE) Authors: Fritsche, E, Humm, A, Huber, R. Deposit date: 1998-10-12 Release date: 1999-02-09 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The ligand-induced structural changes of human L-Arginine:Glycine amidinotransferase. A mutational and crystallographic study. J.Biol.Chem., 274, 1999
1TAR	CRYSTALLINE MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE EXISTS IN ONLY TWO CONFORMATIONS Descriptor: ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE Authors: Hohenester, E, Jansonius, J.N. Deposit date: 1993-10-04 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystalline mitochondrial aspartate aminotransferase exists in only two conformations. J.Mol.Biol., 236, 1994
1TAS	CRYSTALLINE MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE EXISTS IN ONLY TWO CONFORMATIONS Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID, ASPARTATE AMINOTRANSFERASE Authors: Hohenester, E, Jansonius, J.N. Deposit date: 1993-10-04 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystalline mitochondrial aspartate aminotransferase exists in only two conformations. J.Mol.Biol., 236, 1994
1TAT	CRYSTALLINE MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE EXISTS IN ONLY TWO CONFORMATIONS Descriptor: ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE Authors: Hohenester, E, Jansonius, J.N. Deposit date: 1993-10-04 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystalline mitochondrial aspartate aminotransferase exists in only two conformations. J.Mol.Biol., 236, 1994
1AKB	STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5'-PHOSPHATE-BINDING LYSINE RESIDUE Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYLENE)-AMINO]-SUCCINIC ACID, ASPARTATE AMINOTRANSFERASE Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1994-02-28 Release date: 1994-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue. Biochemistry, 34, 1995
1AKA	STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5'-PHOSPHATE-BINDING LYSINE RESIDUE Descriptor: ASPARTATE AMINOTRANSFERASE, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1994-02-28 Release date: 1994-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue. Biochemistry, 34, 1995
1AKC	Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its pyridoxal-5'-phosphate-binding lysine residue Descriptor: 4-[(1,3-DICARBOXY-PROPYLAMINO)-METHYL]-3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDINIUM, ASPARTATE AMINOTRANSFERASE Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1994-02-28 Release date: 1994-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue. Biochemistry, 34, 1995
1AMA	DOMAIN CLOSURE IN MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID, ASPARTATE AMINOTRANSFERASE Authors: Vincent, M.G, Genovesio-Taverne, J.-C, Jansonius, J.N. Deposit date: 1992-02-05 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Domain closure in mitochondrial aspartate aminotransferase. J.Mol.Biol., 227, 1992
1JDX	CRYSTAL STRUCTURE OF HUMAN L-ARGININE:GLYCINE AMIDINOTRANSFERASE IN COMPLEX WITH L-NORVALINE Descriptor: NORVALINE, PROTEIN (L-ARGININE:GLYCINE AMIDINOTRANSFERASE) Authors: Fritsche, E, Humm, A, Huber, R. Deposit date: 1998-10-12 Release date: 1999-02-09 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The ligand-induced structural changes of human L-Arginine:Glycine amidinotransferase. A mutational and crystallographic study. J.Biol.Chem., 274, 1999
1JDW	CRYSTAL STRUCTURE AND MECHANISM OF L-ARGININE: GLYCINE AMIDINOTRANSFERASE: A MITOCHONDRIAL ENZYME INVOLVED IN CREATINE BIOSYNTHESIS Descriptor: BETA-MERCAPTOETHANOL, L-ARGININE:GLYCINE AMIDINOTRANSFERASE Authors: Humm, A, Fritsche, E, Steinbacher, S, Huber, R. Deposit date: 1997-01-22 Release date: 1998-01-28 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis. EMBO J., 16, 1997
1IVR	STRUCTURE OF ASPARTATE AMINOTRANSFERASE Descriptor: ASPARTATE AMINOTRANSFERASE, N-PYRIDOXYL-2,3-DIHYDROXYASPARTIC ACID-5-MONOPHOSPHATE Authors: Graf Von Stosch, A. Deposit date: 1996-10-11 Release date: 1997-07-23 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Aspartate aminotransferase complexed with erythro-beta-hydroxyaspartate: crystallographic and spectroscopic identification of the carbinolamine intermediate. Biochemistry, 35, 1996

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