1R0E
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![BU of 1r0e by Molmil](/molmil-images/mine/1r0e) | Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor | Descriptor: | 3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE, CITRATE ANION, Glycogen synthase kinase-3 beta | Authors: | Allard, J, Nikolcheva, T, Gong, L, Wang, J, Dunten, P, Avnur, Z, Waters, R, Sun, Q, Skinner, B. | Deposit date: | 2003-09-20 | Release date: | 2004-10-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | From genetics to therapeutics: the Wnt pathway and osteoporosis To be Published
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2LF8
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![BU of 2lf8 by Molmil](/molmil-images/mine/2lf8) | |
1R36
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![BU of 1r36 by Molmil](/molmil-images/mine/1r36) | NMR-based structure of autoinhibited murine Ets-1 deltaN301 | Descriptor: | C-ets-1 protein | Authors: | Lee, G.M, Donaldson, L.W, Pufall, M.A, Kang, H.-S, Pot, I, Graves, B.J, McIntosh, L.P. | Deposit date: | 2003-09-30 | Release date: | 2004-11-09 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | The Structural and Dynamic Basis of Ets-1 DNA Binding Autoinhibition J.Biol.Chem., 280, 2005
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1SDY
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![BU of 1sdy by Molmil](/molmil-images/mine/1sdy) | STRUCTURE SOLUTION AND MOLECULAR DYNAMICS REFINEMENT OF THE YEAST CU,ZN ENZYME SUPEROXIDE DISMUTASE | Descriptor: | COPPER (II) ION, COPPER,ZINC SUPEROXIDE DISMUTASE, ZINC ION | Authors: | Djinovic, K, Gatti, G, Coda, A, Antolini, L, Pelosi, G, Desideri, A, Falconi, M, Marmocchi, F, Rotilio, G, Bolognesi, M. | Deposit date: | 1991-06-14 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure solution and molecular dynamics refinement of the yeast Cu,Zn enzyme superoxide dismutase. Acta Crystallogr.,Sect.B, 47, 1991
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1SHK
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![BU of 1shk by Molmil](/molmil-images/mine/1shk) | |
2ME6
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![BU of 2me6 by Molmil](/molmil-images/mine/2me6) | NMR Structure of the homeodomain transcription factor Gbx1 from Homo sapiens in complex with the DNA sequence CGACTAATTAGTCG | Descriptor: | DNA (5'-D(*CP*GP*AP*CP*TP*AP*AP*TP*TP*AP*GP*TP*CP*G)-3'), Homeobox protein GBX-1 | Authors: | Proudfoot, A, Serrano, P, Geralt, M, Wuthrich, K, Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL) | Deposit date: | 2013-09-23 | Release date: | 2013-10-30 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR Structure of the homeodomain transcription factor Gbx1 from Homo sapiens in complex with the DNA sequence CGACTAATTAGTCG To be Published
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2MGQ
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![BU of 2mgq by Molmil](/molmil-images/mine/2mgq) | Structure of CEH37 Homeodomain | Descriptor: | Homeobox protein ceh-37 | Authors: | Moon, S, Lee, W. | Deposit date: | 2013-11-04 | Release date: | 2014-11-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of CEH37 Homeodomain To be Published
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2M34
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![BU of 2m34 by Molmil](/molmil-images/mine/2m34) | |
2MD5
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![BU of 2md5 by Molmil](/molmil-images/mine/2md5) | Structure of uninhibited ETV6 ETS domain | Descriptor: | Transcription factor ETV6 | Authors: | De, S, Mcintosh, L.P, Chan, A.C, Coyne, H.J, Okon, M, Graves, B.J, Murphy, M.E. | Deposit date: | 2013-08-29 | Release date: | 2013-12-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6. J.Mol.Biol., 426, 2014
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1RG8
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![BU of 1rg8 by Molmil](/molmil-images/mine/1rg8) | |
2ME0
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![BU of 2me0 by Molmil](/molmil-images/mine/2me0) | |
1Q04
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![BU of 1q04 by Molmil](/molmil-images/mine/1q04) | Crystal structure of FGF-1, S50E/V51N | Descriptor: | FORMIC ACID, Heparin-binding growth factor 1 | Authors: | Kim, J, Blaber, M. | Deposit date: | 2003-07-15 | Release date: | 2004-07-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Sequence swapping does not result in conformation swapping for the beta4/beta5 and beta8/beta9 beta-hairpin turns in human acidic fibroblast growth factor Protein Sci., 14, 2005
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1PPG
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![BU of 1ppg by Molmil](/molmil-images/mine/1ppg) | The refined 2.3 angstroms crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor | Descriptor: | HUMAN LEUKOCYTE ELASTASE, MEO-SUCCINYL-ALA-ALA-PRO-VAL CHLOROMETHYLKETONE, alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Bode, W, Wei, A-Z. | Deposit date: | 1991-10-24 | Release date: | 1994-01-31 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor. FEBS Lett., 234, 1988
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2M9U
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![BU of 2m9u by Molmil](/molmil-images/mine/2m9u) | Solution NMR structure of the C-terminal domain (CTD) of Moloney murine leukemia virus integrase, Northeast Structural Genomics Target OR41A | Descriptor: | Integrase p46 | Authors: | Aiyer, S, Rossi, P, Schneider, W.M, Chander, A, Roth, M.J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-06-19 | Release date: | 2013-12-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction. Nucleic Acids Res., 42, 2014
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1PYX
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![BU of 1pyx by Molmil](/molmil-images/mine/1pyx) | GSK-3 Beta complexed with AMP-PNP | Descriptor: | Glycogen synthase kinase-3 beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Bertrand, J.A, Thieffine, S, Vulpetti, A, Cristiani, C, Valsasina, B, Knapp, S, Kalisz, H.M, Flocco, M. | Deposit date: | 2003-07-09 | Release date: | 2003-10-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors J.Mol.Biol., 333, 2003
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1Q03
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![BU of 1q03 by Molmil](/molmil-images/mine/1q03) | Crystal structure of FGF-1, S50G/V51G mutant | Descriptor: | Heparin-binding growth factor 1 | Authors: | Kim, J, Blaber, M. | Deposit date: | 2003-07-15 | Release date: | 2004-07-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Sequence swapping does not result in conformation swapping for the beta4/beta5 and beta8/beta9 beta-hairpin turns in human acidic fibroblast growth factor Protein Sci., 14, 2005
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1PXK
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![BU of 1pxk by Molmil](/molmil-images/mine/1pxk) | HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-Dimethyl-thiazol-5-yl)pyrimidin-2-yl]-N'-hydroxyiminoformamide | Descriptor: | Cell division protein kinase 2, N-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]-N'-HYDROXYIMIDOFORMAMIDE | Authors: | Wu, S.Y, McNae, I, Kontopidis, G, McClue, S.J, McInnes, C, Stewart, K.J, Wang, S, Zheleva, D.I, Marriage, H, Lane, D.P, Taylor, P, Fischer, P.M, Walkinshaw, M.D. | Deposit date: | 2003-07-04 | Release date: | 2003-12-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop Structure, 11, 2003
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2MWA
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![BU of 2mwa by Molmil](/molmil-images/mine/2mwa) | |
2MWF
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![BU of 2mwf by Molmil](/molmil-images/mine/2mwf) | |
1Q3D
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![BU of 1q3d by Molmil](/molmil-images/mine/1q3d) | GSK-3 Beta complexed with Staurosporine | Descriptor: | GLYCOGEN SYNTHASE KINASE-3 BETA, STAUROSPORINE | Authors: | Bertrand, J.A, Thieffine, S, Vulpetti, A, Cristiani, C, Valsasina, B, Knapp, S, Kalisz, H.M, Flocco, M. | Deposit date: | 2003-07-29 | Release date: | 2003-10-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors J.Mol.Biol., 333, 2003
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1PXL
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![BU of 1pxl by Molmil](/molmil-images/mine/1pxl) | HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR [4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-trifluoromethyl-phenyl)-amine | Descriptor: | 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE, Cell division protein kinase 2 | Authors: | Wu, S.Y, McNae, I, Kontopidis, G, McClue, S.J, McInnes, C, Stewart, K.J, Wang, S, Zheleva, D.I, Marriage, H, Lane, D.P, Taylor, P, Fischer, P.M, Walkinshaw, M.D. | Deposit date: | 2003-07-04 | Release date: | 2003-12-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop Structure, 11, 2003
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2N7K
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![BU of 2n7k by Molmil](/molmil-images/mine/2n7k) | Unveiling the structural determinants of KIAA0323 binding preference for NEDD8 | Descriptor: | NEDD8, Protein KHNYN | Authors: | Santonico, E, Nepravishta, R, Mattioni, A, Valentini, E, Mandaliti, W, Procopio, R, Iannuccelli, M, Castagnoli, L, Polo, S, Paci, M, Cesareni, G. | Deposit date: | 2015-09-14 | Release date: | 2016-09-14 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Unveiling the structural determinants of KIAA0323 binding preference for NEDD8 To be Published
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2NNT
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![BU of 2nnt by Molmil](/molmil-images/mine/2nnt) | General structural motifs of amyloid protofilaments | Descriptor: | Transcription elongation regulator 1 | Authors: | Ferguson, N, Becker, J, Tidow, H, Tremmel, S, Sharpe, T.D, Krause, G, Flinders, J, Petrovich, M, Berriman, J, Oschkinat, H, Fersht, A.R. | Deposit date: | 2006-10-24 | Release date: | 2006-11-14 | Last modified: | 2023-12-27 | Method: | SOLID-STATE NMR | Cite: | General structural motifs of amyloid protofilaments. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2K3X
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![BU of 2k3x by Molmil](/molmil-images/mine/2k3x) | Solution structure of EAF3 chromo barrel domain | Descriptor: | Chromatin modification-related protein EAF3 | Authors: | Mer, G, Xu, C. | Deposit date: | 2008-05-19 | Release date: | 2008-09-16 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural Basis for the Recognition of Methylated Histone H3K36 by the Eaf3 Subunit of Histone Deacetylase Complex Rpd3S. Structure, 16, 2008
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1SAN
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![BU of 1san by Molmil](/molmil-images/mine/1san) | |