PDB: 1012 resultsInfo pagesStatus searchChemie searchBIRD

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4FH2	Structure of s70c beta-lactamase bound to sulbactam Descriptor: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, SULBACTAM Authors: Rodkey, E.A, van den Akker, F. Deposit date: 2012-06-05 Release date: 2012-09-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Crystal structure of a pre-acylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase J.Am.Chem.Soc., 134, 2012
4GOG	Crystal structure of the GES-1 imipenem acyl-enzyme complex Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase GES-1, IODIDE ION, ... Authors: Smith, C.A, Vakulenko, S.B, Munoz, J. Deposit date: 2012-08-20 Release date: 2013-07-24 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Structural basis for progression toward the carbapenemase activity in the GES family of beta-lactamases. J.Am.Chem.Soc., 134, 2012
6B5X	Beta-Lactamase, unmixed shards crystal form Descriptor: Beta-lactamase, PHOSPHATE ION Authors: Pandey, S. Deposit date: 2017-09-29 Release date: 2018-06-27 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography. BMC Biol., 16, 2018
6B6F	Beta-Lactamase, mixed with Ceftriaxone, needles crystal form, 2sec Descriptor: Beta-lactamase, Ceftriaxone Authors: Pandey, S, Schmidt, M. Deposit date: 2017-10-01 Release date: 2018-06-27 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography. BMC Biol., 16, 2018
4HBU	Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104) Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, Beta-lactamase, ... Authors: Docquier, J.D, Benvenuti, M, Bruneau, J.M, Rossolini, G.M, Miossec, C, Black, M.T, Mangani, S. Deposit date: 2012-09-28 Release date: 2013-04-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases Antimicrob.Agents Chemother., 57, 2013
4GNU	Crystal structure of GES-5 carbapenemase Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase GES-5 Authors: Smith, C.A, Vakulenko, S.B. Deposit date: 2012-08-17 Release date: 2013-07-24 Method: X-RAY DIFFRACTION (1.09 Å) Cite: Structural basis for progression toward the carbapenemase activity in the GES family of beta-lactamases. J.Am.Chem.Soc., 134, 2012
6D15	Crystal structure of KPC-2 complexed with compound 1 Descriptor: Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, [(6,7-dimethyl-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid Authors: Pemberton, O.A, Chen, Y. Deposit date: 2018-04-11 Release date: 2019-04-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62, 2019
4EUZ	Crystal structure of serratia fonticola carbapenemase SFC-1 S70A-Meropenem complex Descriptor: (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 1,2-ETHANEDIOL, Carbapenem-hydrolizing beta-lactamase SFC-1, ... Authors: Fonseca, F, Spencer, J. Deposit date: 2012-04-25 Release date: 2012-05-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.08 Å) Cite: The basis for carbapenem hydrolysis by class A beta-lactamases: a combined investigation using crystallography and simulations. J.Am.Chem.Soc., 134, 2012
6D16	Crystal structure of KPC-2 complexed with compound 2 Descriptor: Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, [(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid Authors: Pemberton, O.A, Chen, Y. Deposit date: 2018-04-11 Release date: 2019-04-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62, 2019
4DXC	Crystal structure of the engineered MBP TEM-1 fusion protein RG13, C2 space group Descriptor: Maltose-binding periplasmic protein, Beta-lactamase TEM chimera, ZINC ION Authors: van den Akker, F, Ke, W. Deposit date: 2012-02-27 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of an Engineered beta-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation. Plos One, 7, 2012
4H8R	Imipenem complex of GES-5 carbapenemase Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Extended-spectrum beta-lactamase GES-5, IODIDE ION, ... Authors: Smith, C.A, Vakulenko, S.B. Deposit date: 2012-09-23 Release date: 2013-07-24 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Structural basis for progression toward the carbapenemase activity in the GES family of beta-lactamases. J.Am.Chem.Soc., 134, 2012
4HBT	Crystal structure of native CTX-M-15 extended-spectrum beta-lactamase Descriptor: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... Authors: Docquier, J.D, Benvenuti, M, Bruneau, J.M, Rossolini, G.M, Miossec, C, Black, M.T, Mangani, S. Deposit date: 2012-09-28 Release date: 2013-04-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases Antimicrob.Agents Chemother., 57, 2013

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