8SCP
 
 | | Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 1h | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | | Deposit date: | 2023-04-05 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
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8SCG
 | | Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 0h (Ground State) | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 3'-Amino DNA Primer, CALCIUM ION, ... | | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | | Deposit date: | 2023-04-05 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
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8SCO
 | | Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 0h (Ground State) | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 3'-Amino DNA primer, CALCIUM ION, ... | | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | | Deposit date: | 2023-04-05 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
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8SCQ
 | | Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 2h | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | | Deposit date: | 2023-04-05 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
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8SCT
 | | Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 24h | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | | Deposit date: | 2023-04-05 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
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2HHT
 | | C:O6-methyl-guanine pair in the polymerase-2 basepair position | | Descriptor: | 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*TP*CP*G)-3', 5'-D(*GP*TP*AP*CP*(6OG)P*AP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', DNA polymerase I, ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-06-28 | | Release date: | 2006-12-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HVH
 | | ddCTP:O6MeG pair in the polymerase active site (0 position) | | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*CP*A*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DDG))-3', ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-07-28 | | Release date: | 2006-12-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.492 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HVI
 | | ddCTP:G pair in the polymerase active site (0 position) | | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*C*AP*TP*GP*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DDG))-3', ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-07-28 | | Release date: | 2006-12-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HW3
 | | T:O6-methyl-guanine pair in the polymerase postinsertion site (-1 basepair position) | | Descriptor: | 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*TP*T)-3', 5'-D(*GP*TP*A*CP*(6OG)P*AP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', DNA Polymerase I, ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-07-31 | | Release date: | 2006-12-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HHW
 | | ddTTP:O6-methyl-guanine pair in the polymerase active site, in the closed conformation | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DDG))-3', ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-06-28 | | Release date: | 2006-12-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HHS
 | | O6-methyl:C pair in the polymerase-10 basepair position | | Descriptor: | 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*GP*CP*AP*TP*GP*A)-3', DNA polymerase I, ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-06-28 | | Release date: | 2006-12-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HHQ
 | | O6-methyl-guanine:T pair in the polymerase-10 basepair position | | Descriptor: | 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*GP*CP*CP*TP*GP*AP*CP*TP*CP*GP*TP*AP*TP*GP*A)-3', DNA polymerase I, ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-06-28 | | Release date: | 2006-12-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HHU
 | | C:O6-methyl-guanine in the polymerase postinsertion site (-1 basepair position) | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*CP*C)-3', 5'-D(*GP*TP*AP*CP*(6OG)P*GP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-06-28 | | Release date: | 2006-12-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HHV
 | | T:O6-methyl-guanine in the polymerase-2 basepair position | | Descriptor: | 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*TP*TP*G)-3', 5'-D(*GP*TP*AP*CP*(6OG)P*AP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', DNA Polymerase I, ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-06-28 | | Release date: | 2006-12-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HHX
 | | O6-methyl-guanine in the polymerase template preinsertion site | | Descriptor: | 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*G)-3', DNA Polymerase I, ... | | Authors: | Warren, J.J, Forsberg, L.J, Beese, L.S. | | Deposit date: | 2006-06-28 | | Release date: | 2006-12-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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3PX0
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3PV8
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3PX6
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3PX4
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1NKB
 | | A BACILLUS DNA POLYMERASE I PRODUCT COMPLEX BOUND TO A GUANINE-THYMINE MISMATCH AFTER THREE ROUNDS OF PRIMER EXTENSION, FOLLOWING INCORPORATION OF DCTP, DGTP, AND DTTP. | | Descriptor: | DNA POLYMERASE I, DNA PRIMER STRAND, DNA TEMPLATE STRAND, ... | | Authors: | Johnson, S.J, Beese, L.S. | | Deposit date: | 2003-01-02 | | Release date: | 2004-03-30 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of mismatch replication errors observed in a DNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
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1NJY
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1NKC
 | | A BACILLUS DNA POLYMERASE I PRODUCT COMPLEX BOUND TO A GUANINE-THYMINE MISMATCH AFTER FIVE ROUNDS OF PRIMER EXTENSION, FOLLOWING INCORPORATION OF DCTP, DGTP, DTTP, AND DATP. | | Descriptor: | DNA POLYMERASE I, DNA PRIMER STRAND, DNA TEMPLATE STRAND, ... | | Authors: | Johnson, S.J, Beese, L.S. | | Deposit date: | 2003-01-02 | | Release date: | 2004-03-30 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structures of mismatch replication errors observed in a DNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
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1NJX
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1NK6
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1NK8
 | | A BACILLUS DNA POLYMERASE I PRODUCT COMPLEX BOUND TO A GUANINE-THYMINE MISMATCH AFTER A SINGLE ROUND OF PRIMER EXTENSION, FOLLOWING INCORPORATION OF DCTP. | | Descriptor: | DNA POLYMERASE I, DNA PRIMER STRAND, DNA TEMPLATE STRAND, ... | | Authors: | Johnson, S.J, Beese, L.S. | | Deposit date: | 2003-01-02 | | Release date: | 2004-03-30 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of mismatch replication errors observed in a DNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
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