2HHX

O6-methyl-guanine in the polymerase template preinsertion site

Summary for 2HHX

• Entry DOI: 10.2210/pdb2hhx/pdb
• Related: 2HHQ 2HHS 2HHT 2HHU 2HHV 2HHW 2HHY
• Related PRD ID: PRD_900003
• Descriptor: 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*G)-3', 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', DNA Polymerase I, ... (6 entities in total)
• Functional Keywords: dna polymerase i, dna replication, klenow fragment, protein-dna complex, o6-methyl-guanine, transferase-dna complex, transferase/dna
• Biological source: Geobacillus stearothermophilus; More
• Total number of polymer chains: 3
• Total formula weight: 74022.22

Authors

Warren, J.J.,Forsberg, L.J.,Beese, L.S. (deposition date: 2006-06-28, release date: 2006-12-12, Last modification date: 2024-02-14)

• Primary citation: Warren, J.J.,Forsberg, L.J.,Beese, L.S.; The structural basis for the mutagenicity of O6-methyl-guanine lesions.; Proc.Natl.Acad.Sci.Usa, 103:19701-19706, 2006; PubMed: 17179038; DOI: 10.1073/pnas.0609580103

Experimental method

X-RAY DIFFRACTION (2.26 Å)