4E8B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4e8b by Molmil](/molmil-images/mine/4e8b) | |
3WZH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3wzh by Molmil](/molmil-images/mine/3wzh) | Crystal structure of AfCsx3 | Descriptor: | MANGANESE (II) ION, Uncharacterized protein AF_1864 | Authors: | Yuan, Y.A, Yan, X. | Deposit date: | 2014-09-25 | Release date: | 2015-07-15 | Last modified: | 2022-08-24 | Method: | X-RAY DIFFRACTION (3.31 Å) | Cite: | Crystal structures of CRISPR-associated Csx3 reveal a manganese-dependent deadenylation exoribonuclease. Rna Biol., 12, 2015
|
|
3WZG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3wzg by Molmil](/molmil-images/mine/3wzg) | Crystal structure of AfCsx3 | Descriptor: | Uncharacterized protein AF_1864 | Authors: | Yuan, Y.A, Yan, X. | Deposit date: | 2014-09-25 | Release date: | 2015-07-15 | Last modified: | 2022-08-24 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal structures of CRISPR-associated Csx3 reveal a manganese-dependent deadenylation exoribonuclease. Rna Biol., 12, 2015
|
|
4BLV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4blv by Molmil](/molmil-images/mine/4blv) | Crystal structure of Escherichia coli 23S rRNA (A2030-N6)- methyltransferase RlmJ in complex with S-adenosylmethionine (AdoMet) | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Punekar, A.S, Liljeruhm, J, Shepherd, T.R, Forster, A.C, Selmer, M. | Deposit date: | 2013-05-04 | Release date: | 2013-08-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and Functional Insights Into the Molecular Mechanism of Rrna M6A Methyltransferase Rlmj. Nucleic Acids Res., 41, 2013
|
|
2MIS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mis by Molmil](/molmil-images/mine/2mis) | |
1KP7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1kp7 by Molmil](/molmil-images/mine/1kp7) | Conserved RNA Structure within the HCV IRES eIF3 Binding Site | Descriptor: | Hepatitis C Virus Internal Ribosome Entry Site Fragment | Authors: | Gallego, J, Klinck, R, Collier, A.J, Cole, P.T, Harris, S.J, Harrison, G.P, Aboul-ela, F, Walker, S, Varani, G. | Deposit date: | 2001-12-29 | Release date: | 2002-04-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A conserved RNA structure within the HCV IRES eIF3-binding site. Nat.Struct.Biol., 9, 2002
|
|
4BLU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4blu by Molmil](/molmil-images/mine/4blu) | Crystal structure of Escherichia coli 23S rRNA (A2030-N6)- methyltransferase RlmJ | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Punekar, A.S, Liljeruhm, J, Shepherd, T.R, Forster, A.C, Selmer, M. | Deposit date: | 2013-05-04 | Release date: | 2013-08-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and Functional Insights Into the Molecular Mechanism of Rrna M6A Methyltransferase Rlmj. Nucleic Acids Res., 41, 2013
|
|
4BLW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4blw by Molmil](/molmil-images/mine/4blw) | Crystal structure of Escherichia coli 23S rRNA (A2030-N6)- methyltransferase RlmJ in complex with S-adenosylhomocysteine (AdoHcy) and Adenosine monophosphate (AMP) | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, GLYCEROL, ... | Authors: | Punekar, A.S, Liljeruhm, J, Shepherd, T.R, Forster, A.C, Selmer, M. | Deposit date: | 2013-05-04 | Release date: | 2013-08-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and Functional Insights Into the Molecular Mechanism of Rrna M6A Methyltransferase Rlmj. Nucleic Acids Res., 41, 2013
|
|
5EHK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ehk by Molmil](/molmil-images/mine/5ehk) | |
2PPB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ppb by Molmil](/molmil-images/mine/2ppb) | Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the ntp substrate analog and antibiotic streptolydigin | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA (5'-D(*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*AP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3'), ... | Authors: | Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I, Landick, R. | Deposit date: | 2007-04-28 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for substrate loading in bacterial RNA polymerase. Nature, 448, 2007
|
|
5DER
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5der by Molmil](/molmil-images/mine/5der) | RNA oligonucleotide containing (R)-C5'-ME-2'F U | Descriptor: | RNA oligonucleotide containing (R)-C5'-Me-2'-FU | Authors: | Harp, J.M, Egli, M. | Deposit date: | 2015-08-25 | Release date: | 2016-06-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. J.Org.Chem., 81, 2016
|
|
5HBW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hbw by Molmil](/molmil-images/mine/5hbw) | RNA primer-template complex with 2-methylimidazole-activated monomer analogue | Descriptor: | RNA (5'-R(*(LCC)P*(TLN)P*(LCG)P*UP*AP*CP*A)-3'), [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-(3-methyl-1~{H}-pyrazol-4-yl)phosphinic acid | Authors: | Zhang, W, Tam, C.P, Szostak, J.W. | Deposit date: | 2016-01-03 | Release date: | 2016-12-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
|
|
5HBX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hbx by Molmil](/molmil-images/mine/5hbx) | RNA primer-template complex with 2-methylimidazole-activated monomer analogue-2 binding sites | Descriptor: | RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3'), [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-(3-methyl-1~{H}-pyrazol-4-yl)phosphinic acid | Authors: | Zhang, W, Tam, C.P, Szostak, J.W. | Deposit date: | 2016-01-03 | Release date: | 2016-12-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
|
|
6I1D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i1d by Molmil](/molmil-images/mine/6i1d) | Structure of the Ysh1-Mpe1 nuclease complex from S.cerevisiae | Descriptor: | Endoribonuclease YSH1, GLYCEROL, Protein MPE1, ... | Authors: | Hill, C.H, Boreikaite, V, Kumar, A, Casanal, A, Kubik, P, Degliesposti, G, Maslen, S, Mariani, A, von Loeffelholz, O, Girbig, M, Skehel, M, Passmore, L.A. | Deposit date: | 2018-10-28 | Release date: | 2019-02-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex. Mol.Cell, 73, 2019
|
|
5NKO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nko by Molmil](/molmil-images/mine/5nko) | Solution structure of the C-terminal domain of S. aureus Hibernating Promoting Factor (CTD-SaHPF) | Descriptor: | Ribosome hibernation promotion factor | Authors: | Usachev, K.S, Khusainov, I.S, Ayupov, R.K, Validov, S.Z, Kieffer, B, Yusupov, M.M. | Deposit date: | 2017-03-31 | Release date: | 2017-07-05 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF. EMBO J., 36, 2017
|
|
5C0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c0o by Molmil](/molmil-images/mine/5c0o) | m1A58 tRNA methyltransferase mutant - Y78A | Descriptor: | S-ADENOSYLMETHIONINE, SULFATE ION, tRNA (adenine(58)-N(1))-methyltransferase TrmI | Authors: | Degut, C, Ponchon, L, Folly-Klan, M, Barraud, P, Tisne, C. | Deposit date: | 2015-06-12 | Release date: | 2015-07-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | The m1A58 modification in eubacterial tRNA: An overview of tRNA recognition and mechanism of catalysis by TrmI. Biophys.Chem., 210, 2016
|
|
4A54
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4a54 by Molmil](/molmil-images/mine/4a54) | Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6 | Descriptor: | EDC3, MRNA DECAPPING COMPLEX SUBUNIT 2 | Authors: | Fromm, S.A, Truffault, V, Kamenz, J, Braun, J.E, Hoffmann, N.A, Izaurralde, E, Sprangers, R. | Deposit date: | 2011-10-24 | Release date: | 2012-02-01 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | The Structural Basis of Edc3- and Scd6-Mediated Activation of the Dcp1:Dcp2 Mrna Decapping Complex. Embo J., 31, 2011
|
|
1L9U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1l9u by Molmil](/molmil-images/mine/1l9u) | THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION | Descriptor: | MAGNESIUM ION, RNA POLYMERASE, ALPHA SUBUNIT, ... | Authors: | Murakami, K.S, Masuda, S, Darst, S.A. | Deposit date: | 2002-03-26 | Release date: | 2002-05-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution. Science, 296, 2002
|
|
5C1I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c1i by Molmil](/molmil-images/mine/5c1i) | m1A58 tRNA methyltransferase mutant - D170A | Descriptor: | SULFATE ION, tRNA (adenine(58)-N(1))-methyltransferase TrmI | Authors: | Ponchon, L, Degut, C, Folly-Klan, M, Barraud, P, Tisne, C. | Deposit date: | 2015-06-14 | Release date: | 2015-06-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The m1A58 modification in eubacterial tRNA: An overview of tRNA recognition and mechanism of catalysis by TrmI. Biophys.Chem., 210, 2016
|
|
6NW7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nw7 by Molmil](/molmil-images/mine/6nw7) | Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with S-Adenosyl-L-homocysteine | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, tRNA (guanine-N(1)-)-methyltransferase | Authors: | Thomas, S.E, Whitehouse, A.J, Coyne, A.G, Abell, C, Mendes, V, Blundell, T.L. | Deposit date: | 2019-02-06 | Release date: | 2020-02-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.481 Å) | Cite: | Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Res., 48, 2020
|
|
6NW6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nw6 by Molmil](/molmil-images/mine/6nw6) | Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with S-Adenosyl methionine | Descriptor: | S-ADENOSYLMETHIONINE, SULFATE ION, tRNA (guanine-N(1)-)-methyltransferase | Authors: | Thomas, S.E, Whitehouse, A.J, Coyne, A.G, Abell, C, Mendes, V, Blundell, T.L. | Deposit date: | 2019-02-06 | Release date: | 2020-02-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Res., 48, 2020
|
|
3P8B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3p8b by Molmil](/molmil-images/mine/3p8b) | |
2N0J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2n0j by Molmil](/molmil-images/mine/2n0j) | Solution NMR Structure of the 27 nucleotide engineered neomycin sensing riboswitch RNA-ribostamycin complex | Descriptor: | RIBOSTAMYCIN, RNA_(27-MER) | Authors: | Duchardt-Ferner, E, Gottstein-Schmidtke, S.R, Weigand, J.E, Ohlenschlaeger, O.E, Wurm, J, Hammann, C, Suess, B, Woehnert, J. | Deposit date: | 2015-03-09 | Release date: | 2016-02-03 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | What a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin-Sensing Riboswitch. Angew.Chem.Int.Ed.Engl., 55, 2016
|
|
1HS2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1hs2 by Molmil](/molmil-images/mine/1hs2) | |
7FO8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fo8 by Molmil](/molmil-images/mine/7fo8) | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P07H06 from the F2X-Universal Library | Descriptor: | A1 cistron-splicing factor AAR2, N-[(1E)-2-(hydroxyamino)-2-oxoethylidene]benzamide, Pre-mRNA-splicing factor 8 | Authors: | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | Deposit date: | 2022-08-26 | Release date: | 2022-11-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
|
|