8WAW
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![BU of 8waw by Molmil](/molmil-images/mine/8waw) | De novo transcribing complex 13 (TC13), the early elongation complex with Pol II positioned 13nt downstream of TSS | Descriptor: | Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-08 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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4GVV
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![BU of 4gvv by Molmil](/molmil-images/mine/4gvv) | Crystal Structure of de novo design serine hydrolase OSH55.27, Northeast Structural Genomics Consortium (NESG) Target OR246 | Descriptor: | De novo design serine hydrolase | Authors: | Kuzin, A, Lew, S, Seetharaman, J, Mao, M, Xiao, R, Kohan, E, Rajagopalan, S, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-08-31 | Release date: | 2012-09-12 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.895 Å) | Cite: | Northeast Structural Genomics Consortium Target OR246 To be Published
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2MI7
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![BU of 2mi7 by Molmil](/molmil-images/mine/2mi7) | Solution NMR structure of alpha3Y | Descriptor: | de novo protein a3Y | Authors: | Glover, S.D, Jorge, C, Liang, L, Valentine, K.G, Hammarstrom, L, Tommos, C. | Deposit date: | 2013-12-10 | Release date: | 2014-08-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Photochemical tyrosine oxidation in the structurally well-defined alpha 3Y protein: proton-coupled electron transfer and a long-lived tyrosine radical. J.Am.Chem.Soc., 136, 2014
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8F6R
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![BU of 8f6r by Molmil](/molmil-images/mine/8f6r) | CryoEM structure of designed modular protein oligomer C6-79 | Descriptor: | De novo designed oligomeric protein C6-79 | Authors: | Redler, R.L, Edman, N.I, Baker, D, Ekiert, D, Bhabha, G. | Deposit date: | 2022-11-17 | Release date: | 2023-11-29 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies. Cell, 2024
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7VQL
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![BU of 7vql by Molmil](/molmil-images/mine/7vql) | de novo designed based on 1r26 | Descriptor: | AMMONIUM ION, GLYCEROL, de novo designed protein | Authors: | Zhang, L. | Deposit date: | 2021-10-20 | Release date: | 2022-06-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Rotamer-free protein sequence design based on deep learning and self-consistency. Nat Comput Sci, 2023
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7VQV
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![BU of 7vqv by Molmil](/molmil-images/mine/7vqv) | de novo design based on 1r26 | Descriptor: | GLYCEROL, de novo designed protein | Authors: | Zhang, L. | Deposit date: | 2021-10-20 | Release date: | 2022-06-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Rotamer-free protein sequence design based on deep learning and self-consistency. Nat Comput Sci, 2023
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4KYB
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![BU of 4kyb by Molmil](/molmil-images/mine/4kyb) | Crystal Structure of de novo designed serine hydrolase OSH55.14_E3, Northeast Structural Genomics Consortium Target OR342 | Descriptor: | Designed Protein OR342, PHOSPHATE ION | Authors: | Kuzin, A, Lew, S, Rajagopalan, S, Seetharaman, J, Mao, L, Xiao, R, Lee, D, Raja, S, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-05-28 | Release date: | 2013-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.909 Å) | Cite: | Northeast Structural Genomics Consortium Target OR342 To be Published
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8G0X
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![BU of 8g0x by Molmil](/molmil-images/mine/8g0x) | |
8G0Y
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![BU of 8g0y by Molmil](/molmil-images/mine/8g0y) | |
2LTA
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![BU of 2lta by Molmil](/molmil-images/mine/2lta) | Solution NMR structure of De novo designed protein, rossmann 3x1 fold, Northeast Structural Genomics Consortium target OR157 | Descriptor: | De novo designed protein | Authors: | Liu, G, Koga, R, Koga, N, Xiao, R, Pederson, K, Hamilton, K, Kohan, E, Acton, T.B, Kornhaber, G, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-05-15 | Release date: | 2012-06-13 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Principles for designing ideal protein structures. Nature, 491, 2012
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8W7D
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![BU of 8w7d by Molmil](/molmil-images/mine/8w7d) | Crystal structure of EcPPAT-FR901483 complex | Descriptor: | Amidophosphoribosyltransferase, [(1S,3S,6S,7S,8R,9S)-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-7-oxidanyl-5-azatricyclo[6.3.1.0^1,5]dodecan-9-yl] dihydrogen phosphate | Authors: | Hara, K, Hashimoto, H, Nakahara, M, Sato, M, Watanabe, K. | Deposit date: | 2023-08-30 | Release date: | 2023-12-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Uncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor. J.Am.Chem.Soc., 145, 2023
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8ERZ
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![BU of 8erz by Molmil](/molmil-images/mine/8erz) | |
8ERY
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![BU of 8ery by Molmil](/molmil-images/mine/8ery) | |
8ES2
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![BU of 8es2 by Molmil](/molmil-images/mine/8es2) | |
8ES3
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![BU of 8es3 by Molmil](/molmil-images/mine/8es3) | |
8ES1
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![BU of 8es1 by Molmil](/molmil-images/mine/8es1) | |
8ES0
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![BU of 8es0 by Molmil](/molmil-images/mine/8es0) | |
2LND
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![BU of 2lnd by Molmil](/molmil-images/mine/2lnd) | Solution NMR Structure of DE NOVO DESIGNED PROTEIN, PFK fold, Northeast Structural Genomics Consortium Target OR134 | Descriptor: | DE NOVO DESIGNED PROTEIN, PFK fold | Authors: | Liu, G, Koga, N, Koga, R, Xiao, R, Lee, H, Janjua, H, Kohan, E, Acton, T.B, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-12-23 | Release date: | 2012-01-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Northeast Structural Genomics Consortium Target OR134 To be Published
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2L82
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![BU of 2l82 by Molmil](/molmil-images/mine/2l82) | Solution NMR Structure of de novo designed protein, P-loop NTPase fold, Northeast Structural Genomics Consortium Target OR32 | Descriptor: | DESIGNED PROTEIN OR32 | Authors: | Liu, G, Koga, N, Koga, R, Xiao, R, Hamilton, K, Janjua, H, Tong, S, Acton, T.B, Everett, J, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-12-31 | Release date: | 2011-02-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Northeast Structural Genomics Consortium Target OR32 To be Published
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6U1S
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![BU of 6u1s by Molmil](/molmil-images/mine/6u1s) | Cryo-EM structure of a de novo designed 16-helix transmembrane nanopore, TMHC8_R. | Descriptor: | de novo designed 16-helix transmembrane nanopore, TMHC8_R | Authors: | Johnson, M.J, Reggiano, G, Xu, C, Lu, P, Hsia, Y, Brunette, T.J, DiMaio, F, Baker, D, Kollman, J. | Deposit date: | 2019-08-16 | Release date: | 2020-08-19 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Computational Design of Transmembrane Channels To Be Published
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8OYS
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![BU of 8oys by Molmil](/molmil-images/mine/8oys) | De novo designed TIM barrel fold TBF_24 | Descriptor: | CHLORIDE ION, De novo designed TIM-barrel | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Computational design of soluble functional analogues of integral membrane proteins. Biorxiv, 2024
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8OYY
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![BU of 8oyy by Molmil](/molmil-images/mine/8oyy) | De novo designed soluble GPCR-like fold GLF_32 | Descriptor: | CHLORIDE ION, De novo designed soluble GPCR-like protein, POTASSIUM ION | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Computational design of soluble functional analogues of integral membrane proteins. Biorxiv, 2024
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5I34
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![BU of 5i34 by Molmil](/molmil-images/mine/5i34) | Adenylosuccinate synthetase from Cryptococcus neoformans complexed with GDP and IMP | Descriptor: | Adenylosuccinate synthetase, GUANOSINE-5'-DIPHOSPHATE, INOSINIC ACID | Authors: | Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B. | Deposit date: | 2016-02-09 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans. Acs Infect Dis., 2, 2016
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5I33
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![BU of 5i33 by Molmil](/molmil-images/mine/5i33) | Unligated adenylosuccinate synthetase from Cryptococcus neoformans | Descriptor: | Adenylosuccinate synthetase | Authors: | Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B. | Deposit date: | 2016-02-09 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans. Acs Infect Dis., 2, 2016
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3Q7Y
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![BU of 3q7y by Molmil](/molmil-images/mine/3q7y) | |