PDB: 2558 resultsInfo pagesStatus searchChemie searchBIRD

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2GNQ	Structure of wdr5 Descriptor: CHLORIDE ION, WD-repeat protein 5 Authors: Min, J, Schuetz, A, Allali-Hassani, A, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) Deposit date: 2006-04-10 Release date: 2006-06-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
2H9N	WDR5 in complex with monomethylated H3K4 peptide Descriptor: H3 histone, WD-repeat protein 5 Authors: Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) Deposit date: 2006-06-10 Release date: 2006-08-01 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
2HES	Cytosolic Iron-sulphur Assembly Protein- 1 Descriptor: CALCIUM ION, Ydr267cp Authors: Srinivasan, V, Michel, H, Lill, R, Daili, J.A.N, Pierik, A.J. Deposit date: 2006-06-22 Release date: 2007-07-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure of the Yeast WD40 Domain Protein Cia1, a Component Acting Late in Iron-Sulfur Protein Biogenesis. Structure, 15, 2007
2H9P	WDR5 in complex with trimethylated H3K4 peptide Descriptor: H3 histone, WD-repeat protein 5 Authors: Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) Deposit date: 2006-06-10 Release date: 2006-08-01 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
2G9A	Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 Descriptor: Histone H3, WD-repeat protein 5 Authors: Chai, J, Han, Z, Wang, H, Shen, Y. Deposit date: 2006-03-06 Release date: 2006-09-06 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 To be published
2H6N	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex Descriptor: Histone H3 K4-Me2 9-residue peptide, WD-repeat protein 5 Authors: Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-05-31 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
2H13	Crystal structure of WDR5/histone H3 complex Descriptor: WD-repeat protein 5, histone H3 lys-4 dimethylated Authors: Couture, J.F, Collazo, E, Trievel, R.C. Deposit date: 2006-05-15 Release date: 2006-07-11 Last modified: 2018-02-07 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Molecular recognition of histone H3 by the WD40 protein WDR5. Nat.Struct.Mol.Biol., 13, 2006
2H6Q	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex Descriptor: Histone H3 K4-Me3 9-residue peptide, WD-repeat protein 5 Authors: Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-06-01 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
2H68	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex Descriptor: WD-repeat protein 5 Authors: Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-05-30 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
2H6K	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex Descriptor: Histone H3 K4-Me 9-residue peptide, WD-repeat protein 5 Authors: Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-05-31 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
2H9L	WDR5delta23 Descriptor: SULFATE ION, WD-repeat protein 5 Authors: Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) Deposit date: 2006-06-10 Release date: 2006-08-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
2H14	Crystal of WDR5 (apo-form) Descriptor: WD-repeat protein 5 Authors: Couture, J.F, Collazo, E, Trievel, R.C. Deposit date: 2006-05-15 Release date: 2006-07-11 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Molecular recognition of histone H3 by the WD40 protein WDR5. Nat.Struct.Mol.Biol., 13, 2006
6PGE	WDR5delta32 bound to ethyl 3-(4-(hydroxymethyl)-1H-imidazol-2-yl)propanoate Descriptor: 1,2-ETHANEDIOL, SULFATE ION, WD repeat-containing protein 5, ... Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG7	WDR5delta32 bound to (2-(3-methoxy-3-phenylpropyl)-1H-imidazol-4-yl)methanol Descriptor: DI(HYDROXYETHYL)ETHER, WD repeat-containing protein 5, {2-[(3S)-3-methoxy-3-phenylpropyl]-1H-imidazol-4-yl}methanol Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGD	WDR5delta32 bound to peptidomimetic Descriptor: N-acetyl-L-alanyl-5-[5-(hydroxymethyl)-1H-imidazol-2-yl]-L-norvalyl-L-valinamide, SULFATE ION, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGC	WDR5delta32 bound to methyl benzyl(4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate Descriptor: SULFATE ION, WD repeat-containing protein 5, methyl benzyl{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG6	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acetamide Descriptor: CHLORIDE ION, N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}acetamide, SULFATE ION, ... Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PBG	Crystal structure of WD-repeat domain of human coatomer subunit Alpha (COPA) Descriptor: Coatomer subunit alpha, L(+)-TARTARIC ACID, UNKNOWN ATOM OR ION Authors: Halabelian, L, Zeng, H, Dong, A, Loppnau, P, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) Deposit date: 2019-06-13 Release date: 2019-06-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Crystal structure of W repeat domain of human coatomer subunit Alpha (COPA) to be published
6PGF	WDR5delta32 bound to N-(4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acrylamide Descriptor: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}prop-2-enamide, SULFATE ION, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG3	WDR5delta23 bound to (2-butyl-1H-imidazol-4-yl)methanol Descriptor: (2-butyl-1H-imidazol-4-yl)methanol, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
3UVN	Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A Descriptor: Histone-lysine N-methyltransferase SETD1A, WD repeat-containing protein 5 Authors: Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. Deposit date: 2011-11-30 Release date: 2011-12-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.792 Å) Cite: The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
3UVM	Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4 Descriptor: Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5 Authors: Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. Deposit date: 2011-11-30 Release date: 2011-12-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.57 Å) Cite: The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
3SMR	Crystal structure of human WD repeat domain 5 with compound Descriptor: 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... Authors: Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) Deposit date: 2011-06-28 Release date: 2011-08-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
3UVK	Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2 Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Histone-lysine N-methyltransferase MLL2, SULFATE ION, ... Authors: Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. Deposit date: 2011-11-30 Release date: 2011-12-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
3UVL	Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3 Descriptor: Histone-lysine N-methyltransferase MLL3, WD repeat-containing protein 5 Authors: Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. Deposit date: 2011-11-30 Release date: 2011-12-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012

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