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1ETT	REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS Descriptor: 4-[(2S)-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxo-3-(piperidin-1-yl)propyl]benzene-1-carboximidamide, EPSILON-THROMBIN Authors: Bode, W, Brandstetter, H. Deposit date: 1992-07-06 Release date: 1994-01-31 Last modified: 2018-09-12 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J.Mol.Biol., 226, 1992
1HEW	REFINEMENT OF AN ENZYME COMPLEX WITH INHIBITOR BOUND AT PARTIAL OCCUPANCY. HEN EGG-WHITE LYSOZYME AND TRI-N-ACETYLCHITOTRIOSE AT 1.75 ANGSTROMS RESOLUTION Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEN EGG WHITE LYSOZYME Authors: Cheetham, J.C, Artymiuk, P.J, Phillips, D.C. Deposit date: 1992-01-20 Release date: 1994-01-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Refinement of an enzyme complex with inhibitor bound at partial occupancy. Hen egg-white lysozyme and tri-N-acetylchitotriose at 1.75 A resolution. J.Mol.Biol., 224, 1992
1ABI	STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRULOG 3 Authors: Qiu, X, Tulinsky, A. Deposit date: 1992-08-24 Release date: 1994-01-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors. Biochemistry, 31, 1992
1YCB	DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE Authors: Cameron, A.D, Smerdon, S.J, Wilkinson, A.J, Habash, J, Helliwell, J.R. Deposit date: 1993-08-10 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy. Biochemistry, 32, 1993
2REN	STRUCTURE OF RECOMBINANT HUMAN RENIN, A TARGET FOR CARDIOVASCULAR-ACTIVE DRUGS, AT 2.5 ANGSTROMS RESOLUTION Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, RENIN Authors: Sielecki, A.R, James, M.N.G. Deposit date: 1992-02-05 Release date: 1994-01-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution. Science, 243, 1989
1ABJ	STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide Authors: Qiu, X, Tulinsky, A. Deposit date: 1992-08-24 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors. Biochemistry, 31, 1992
1YCA	DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY Descriptor: CARBON MONOXIDE, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE Authors: Cameron, A.D, Smerdon, S.J, Wilkinson, A.J, Habash, J, Helliwell, J.R. Deposit date: 1993-08-10 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy. Biochemistry, 32, 1993
1NCC	CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE-ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, IGG2A-KAPPA NC41 FAB (HEAVY CHAIN), ... Authors: Tulip, W.R, Varghese, J.N, Colman, P.M. Deposit date: 1992-01-21 Release date: 1994-01-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface. J.Mol.Biol., 227, 1992
1ENT	X-RAY ANALYSES OF ASPARTIC PROTEINASES. THE THREE-DIMENSIONAL STRUCTURE AT 2.1 ANGSTROMS RESOLUTION OF ENDOTHIAPEPSIN Descriptor: ENDOTHIAPEPSIN, N-(tert-butoxycarbonyl)-L-phenylalanyl-N-{(1S)-1-[(R)-hydroxy(2-{[(2S)-2-methylbutyl]amino}-2-oxoethyl)phosphoryl]-3-methylbutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide, SULFATE ION Authors: Blundell, T.L, Dealwis, C.G. Deposit date: 1992-03-11 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin. J.Mol.Biol., 211, 1990
1ICM	ESCHERICHIA COLI-DERIVED RAT INTESTINAL FATTY ACID BINDING PROTEIN WITH BOUND MYRISTATE AT 1.5 A RESOLUTION AND I-FABPARG106-->GLN WITH BOUND OLEATE AT 1.74 A RESOLUTION Descriptor: INTESTINAL FATTY ACID BINDING PROTEIN, MYRISTIC ACID Authors: Eads, J.C, Sacchettini, J.C, Kromminga, A, Gordon, J.I. Deposit date: 1993-09-20 Release date: 1994-01-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Escherichia coli-derived rat intestinal fatty acid binding protein with bound myristate at 1.5 A resolution and I-FABPArg106-->Gln with bound oleate at 1.74 A resolution. J.Biol.Chem., 268, 1993
2RNS	REFINEMENT OF THE CRYSTAL STRUCTURE OF RIBONUCLEASE S. COMPARISON WITH AND BETWEEN THE VARIOUS RIBONUCLEASE A STRUCTURES Descriptor: RIBONUCLEASE S, SULFATE ION Authors: Kim, E.E, Varadarajan, R, Wyckoff, H.W, Richards, F.M. Deposit date: 1992-02-19 Release date: 1994-01-31 Last modified: 2019-08-14 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Refinement of the crystal structure of ribonuclease S. Comparison with and between the various ribonuclease A structures. Biochemistry, 31, 1992
621P	THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES Descriptor: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER Authors: Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. Deposit date: 1991-06-06 Release date: 1994-01-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
1EED	X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors Descriptor: (2S)-2-[[(3S,4S)-5-cyclohexyl-4-[[(4S,5S)-5-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxidanyl-6-phenyl-hexanoyl]amino]-3-oxidanyl-pentanoyl]amino]-4-methyl-pentanoic acid, ENDOTHIAPEPSIN Authors: Blundell, T.L, Frazao, C, Cooper, J.B. Deposit date: 1992-06-15 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors. Biochemistry, 31, 1992
1ERB	THE INTERACTION OF N-ETHYL RETINAMIDE WITH PLASMA RETINOL-BINDING PROTEIN (RBP) AND THE CRYSTAL STRUCTURE OF THE RETINOID-RBP COMPLEX AT 1.9 ANGSTROMS RESOLUTION Descriptor: N-ETHYL RETINAMIDE, RETINOL BINDING PROTEIN Authors: Zanotti, G, Berni, R. Deposit date: 1993-10-01 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The interaction of N-ethyl retinamide with plasma retinol-binding protein (RBP) and the crystal structure of the retinoid-RBP complex at 1.9-A resolution. J.Biol.Chem., 268, 1993
1RND	NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE Descriptor: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, RIBONUCLEASE A, SULFATE ION Authors: Aguilar, C.F, Thomas, P.J, Mills, A, Moss, D.S, Palmer, R.A. Deposit date: 1991-10-21 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Newly observed binding mode in pancreatic ribonuclease. J.Mol.Biol., 224, 1992
2TGI	CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY Descriptor: TRANSFORMING GROWTH FACTOR ,BETA 2 Authors: Daopin, S, Davies, D.R. Deposit date: 1993-10-20 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. Science, 257, 1992
1EPH	THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS Descriptor: EPIDERMAL GROWTH FACTOR Authors: Kohda, D, Inagaki, F. Deposit date: 1992-03-24 Release date: 1994-01-31 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions. Biochemistry, 31, 1992
1LHH	ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS Descriptor: HUMAN LYSOZYME Authors: Inaka, K, Matsushima, M, Herning, T, Kuroki, R, Yutani, K, Kikuchi, M. Deposit date: 1992-03-27 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with X-ray structure analysis of proline mutants. Biochemistry, 31, 1992
1LLD	MOLECULAR BASIS OF ALLOSTERIC ACTIVATION OF BACTERIAL L-LACTATE DEHYDROGENASE Descriptor: L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Iwata, S, Ohta, T. Deposit date: 1992-06-08 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular basis of allosteric activation of bacterial L-lactate dehydrogenase. J.Mol.Biol., 230, 1993
821P	THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS Descriptor: C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER Authors: Scheidig, A.J, Krengel, U, Pai, E.F, Kabsch, W, Wittinghofer, A, Goody, R.S. Deposit date: 1993-03-29 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry, 32, 1993
3PRK	INHIBITION OF PROTEINASE K BY METHOXYSUCCINYL-ALA-ALA-PRO-ALA-CHLOROMETHYL KETONE. AN X-RAY STUDY AT 2.2-ANGSTROMS RESOLUTION Descriptor: CALCIUM ION, METHOXYSUCCINYL-ALA-ALA-PRO-ALA-CHLOROMETHYL KETONE, PROTEINASE K Authors: Wolf, W.M, Bajorath, J, Mueller, A, Raghunathan, S, Singh, T.P, Hinrichs, W, Saenger, W. Deposit date: 1991-08-07 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Inhibition of proteinase K by methoxysuccinyl-Ala-Ala-Pro-Ala-chloromethyl ketone. An x-ray study at 2.2-A resolution. J.Biol.Chem., 266, 1991
1HBB	HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE Descriptor: HEMOGLOBIN A (DEOXY) (ALPHA CHAIN), HEMOGLOBIN A (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE Authors: Kavanaugh, J.S, Arnone, A. Deposit date: 1992-01-07 Release date: 1994-01-31 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site. Biochemistry, 31, 1992
1HGB	HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Descriptor: HEMOGLOBIN (AQUO MET) (ALPHA CHAIN), HEMOGLOBIN (AQUO MET) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE Authors: Liddington, R, Derewenda, Z, Dodson, E, Hubbard, R, Dodson, G. Deposit date: 1991-10-31 Release date: 1994-01-31 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin. J.Mol.Biol., 228, 1992
1HGA	HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Descriptor: HEMOGLOBIN (DEOXY) (ALPHA CHAIN), HEMOGLOBIN (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE Authors: Liddington, R, Derewenda, Z, Dodson, E, Hubbard, R, Dodson, G. Deposit date: 1991-10-31 Release date: 1994-01-31 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin. J.Mol.Biol., 228, 1992
1HGC	HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Descriptor: HEMOGLOBIN (DEOXY) (BETA CHAIN), HEMOGLOBIN (OXY) (ALPHA CHAIN), OXYGEN MOLECULE, ... Authors: Liddington, R, Derewenda, Z, Dodson, E, Hubbard, R, Dodson, G. Deposit date: 1991-10-31 Release date: 1994-01-31 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin. J.Mol.Biol., 228, 1992

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