PDB: 13422 resultsInfo pagesStatus searchChemie searchBIRD

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5VFC	WDR5 bound to inhibitor MM-589 Descriptor: 1,2-ETHANEDIOL, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ... Authors: Stuckey, J.A. Deposit date: 2017-04-07 Release date: 2017-06-28 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J. Med. Chem., 60, 2017
1E8S	Alu domain of the mammalian SRP (potential Alu retroposition intermediate) Descriptor: 7SL RNA, 88-MER, EUROPIUM (III) ION, ... Authors: Weichenrieder, O, Wild, K, Strub, K, Cusack, S. Deposit date: 2000-09-29 Release date: 2000-11-08 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (4 Å) Cite: Structure and Assembly of the Alu Domain of the Mammalian Signal Recognition Particle Nature, 408, 2000
2K2U	NMR Structure of the complex between Tfb1 subunit of TFIIH and the activation domain of VP16 Descriptor: Alpha trans-inducing protein, RNA polymerase II transcription factor B subunit 1 Authors: Langlois, C, Mas, C, Di Lello, P, Miller Jenkins, P.M, Legault, J, Omichinski, J.G. Deposit date: 2008-04-11 Release date: 2008-08-12 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: NMR Structure of the Complex between the Tfb1 Subunit of TFIIH and the Activation Domain of VP16: Structural Similarities between VP16 and p53. J.Am.Chem.Soc., 130, 2008
6ZUZ	TFIIS N-terminal domain (TND) from human Elongin-A Descriptor: Elongin-A Authors: Veverka, V. Deposit date: 2020-07-23 Release date: 2021-12-01 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
4M2Y	Structure of human DNA polymerase beta complexed with 8-BrG as the template base in a 1-nucleotide gapped DNA Descriptor: DNA polymerase beta, SODIUM ION, down-primer, ... Authors: Koag, M.C, Min, K, Monzingo, A.F, Lee, S. Deposit date: 2013-08-05 Release date: 2014-01-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
5OKI	Crystal structure of the Ctf18-1-8 module from Ctf18-RFC in complex with a 63 kDa fragment of DNA Polymerase epsilon Descriptor: Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, DNA polymerase epsilon catalytic subunit A, ... Authors: Grabarczyk, D.B, Kisker, C. Deposit date: 2017-07-25 Release date: 2017-12-20 Last modified: 2018-01-10 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Structural Basis for the Recruitment of Ctf18-RFC to the Replisome. Structure, 26, 2018
1DRZ	U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX Descriptor: MAGNESIUM ION, PROTEIN (U1 SMALL RIBONUCLEOPROTEIN A), RNA (HEPATITIS DELTA VIRUS GENOMIC RIBOZYME), ... Authors: Ferre-D'Amare, A.R, Zhou, K, Doudna, J.A. Deposit date: 1998-09-01 Release date: 1999-02-16 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of a hepatitis delta virus ribozyme. Nature, 395, 1998
4FO6	Crystal structure of the pre-catalytic ternary complex of polymerase lambda with a dATP analog opposite a templating T and an rCMP at the primer terminus. Descriptor: 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, 5'-D(*CP*AP*GP*TP*AP)-R(P*C)-3', 5'-D(*CP*GP*GP*CP*TP*GP*TP*AP*CP*TP*G)-3', ... Authors: Gosavi, R.A, Moon, A.F, Kunkel, T.A, Pedersen, L.C, Bebenek, K. Deposit date: 2012-06-20 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.007 Å) Cite: The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda Nucleic Acids Res., 40, 2012
2VP3	DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, VP39 Authors: Hodel, A.E, Gershon, P.D, Quiocho, F.A. Deposit date: 1996-12-16 Release date: 1997-09-17 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Specific protein recognition of an mRNA cap through its alkylated base. Nat.Struct.Biol., 4, 1997
1ZT2	Heterodimeric structure of the core primase. Descriptor: DNA primase large subunit, DNA primase small subunit, SULFATE ION, ... Authors: Lao-Sirieix, S.H, Nookala, R.K, Roversi, P, Bell, S.D, Pellegrini, L. Deposit date: 2005-05-26 Release date: 2005-11-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3.33 Å) Cite: Structure of the heterodimeric core primase. Nat.Struct.Mol.Biol., 12, 2005
2GS0	NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the activation domain of p53 Descriptor: Cellular tumor antigen p53, RNA polymerase II transcription factor B subunit 1 Authors: Di Lello, P, Jones, T.N, Nguyen, B.D, Legault, P, Omichinski, J.G. Deposit date: 2006-04-25 Release date: 2006-10-31 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. Mol.Cell, 22, 2006
3NFQ	Crystal structure of the conserved central domain of yeast Spn1/Iws1 Descriptor: Transcription factor IWS1 Authors: Stargell, L.A, Luger, K. Deposit date: 2010-06-10 Release date: 2010-10-13 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: The Transcription Factor Spn1 Regulates Gene Expression via a Highly Conserved Novel Structural Motif. J.Mol.Biol., 404, 2010
4NM1	Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position Descriptor: 5'-D(*CP*CP*GP*AP*CP*GP*(BGM)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... Authors: Koag, M.-C, Min, K, Monzingo, A.F, Lee, S. Deposit date: 2013-11-14 Release date: 2014-01-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.415 Å) Cite: Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
4NM2	Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-G at N-1 position and G-C at N position Descriptor: 5'-D(*CP*CP*GP*AP*CP*GP*(BGM)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... Authors: Koag, M.-C, Min, K, Monzingo, A.F, Lee, S. Deposit date: 2013-11-14 Release date: 2014-01-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.524 Å) Cite: Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
4NLK	Structure of human DNA polymerase beta complexed with 8BrG in the template base-paired with incoming non-hydrolyzable CTP Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 5'-D(*CP*CP*GP*AP*CP*(BGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', ... Authors: Koag, M.-C, Min, K, Monzingo, A.F, Lee, S. Deposit date: 2013-11-14 Release date: 2014-01-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.494 Å) Cite: Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
4NLN	Structure of human DNA polymerase beta complexed with nicked DNA containing a template 8BrG and incoming CTP Descriptor: 5'-D(*CP*CP*GP*AP*CP*(BGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... Authors: Koag, M.-C, Min, K, Monzingo, A.F, Lee, S. Deposit date: 2013-11-14 Release date: 2014-01-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.261 Å) Cite: Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
4NLZ	Structure of human DNA polymerase beta complexed with nicked DNA containing a mismatched template 8BrG and incoming GTP Descriptor: 5'-D(*CP*CP*GP*AP*CP*(BGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*AP*G)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... Authors: Koag, M.-C, Min, K, Monzingo, A.F, Lee, S. Deposit date: 2013-11-14 Release date: 2014-01-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.683 Å) Cite: Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
2LOX	NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2 Descriptor: DNA repair protein RAD2, RNA polymerase II transcription factor B subunit 1 Authors: Lafrance-Vanasse, J, Legault, P, Omichinski, J. Deposit date: 2012-01-27 Release date: 2012-02-15 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural and functional characterization of interactions involving the Tfb1 subunit of TFIIH and the NER factor Rad2. Nucleic Acids Res., 40, 2012
6FDP	NMR structure of the second TPR domain of the human RPAP3 protein in complex with HSP90 peptide DTSRMEEVD Descriptor: Heat shock protein HSP 90-alpha, RNA polymerase II-associated protein 3 Authors: Quinternet, M, Chagot, M.E, Manival, X. Deposit date: 2017-12-26 Release date: 2018-08-01 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure, 26, 2018
6FDT	NMR structure of the second TPR domain of the human RPAP3 protein in complex with HSP70 peptide SGPTIEEVD Descriptor: Heat shock 70 kDa protein 1B, RNA polymerase II-associated protein 3 Authors: Quinternet, M, Chagot, M.E, Manival, X. Deposit date: 2017-12-26 Release date: 2018-08-01 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure, 26, 2018
7CCG	Crystal structure of ClA1, a kind of a chlorinase from soil bacteria Descriptor: 5'-CHLORO-5'-DEOXYADENOSINE, DNA-directed RNA polymerase subunit delta, METHIONINE Authors: Ouyang, Z, Li, Y. Deposit date: 2020-06-17 Release date: 2020-09-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of ClA1, a type of chlorinase from soil bacteria. Biochem.Biophys.Res.Commun., 530, 2020
6CKX	Structure of CDK12/CycK in complex with a small molecule inhibitor N-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-((1r,4r)-4-(quinazolin-2-ylamino)cyclohexyl)acetamide Descriptor: Cyclin-K, Cyclin-dependent kinase 12, MAGNESIUM ION, ... Authors: Klein, M.G. Deposit date: 2018-03-01 Release date: 2018-08-29 Last modified: 2018-09-26 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors. J. Med. Chem., 61, 2018
4M47	structure of human DNA polymerase complexed with 8-BrG in the template base paired with incoming non-hydrolyzable GTP Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA polymerase beta, MAGNESIUM ION, ... Authors: Koag, M.C, Min, K, Monzingo, A.F, Lee, S. Deposit date: 2013-08-06 Release date: 2014-01-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.37 Å) Cite: Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
1UET	Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure Descriptor: ACETATE ION, CALCIUM ION, MAGNESIUM ION, ... Authors: Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2003-05-21 Release date: 2003-12-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. Embo J., 22, 2003
1JTE	Crystal Structure Analysis of VP39 F180W mutant Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, VP39 Authors: Hu, G, Oguro, A, Gershon, P.D, Quiocho, F.A. Deposit date: 2001-08-20 Release date: 2002-07-10 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2 Å) Cite: The "cap-binding slot" of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap. Biochemistry, 41, 2002

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