6VUQ
| Crystal structure of CHIKV nsP3 macrodomain soaked with ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Nonstructural polyprotein | Authors: | Wu, M. | Deposit date: | 2020-02-16 | Release date: | 2021-01-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design. Plos One, 16, 2021
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8BS9
| Structure of USP36 in complex with Ubiquitin-PA | Descriptor: | Polyubiquitin-B, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 36, ... | Authors: | O'Dea, R, Gersch, M. | Deposit date: | 2022-11-24 | Release date: | 2023-07-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36. Nat.Chem.Biol., 19, 2023
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8BS3
| Structure of USP36 in complex with Fubi-PA | Descriptor: | 40S ribosomal protein S30, Ubiquitin carboxyl-terminal hydrolase 36, ZINC ION, ... | Authors: | O'Dea, R, Gersch, M. | Deposit date: | 2022-11-24 | Release date: | 2023-07-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36. Nat.Chem.Biol., 19, 2023
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7T9W
| Crystal structure of the Nsp3 bSM (Betacoronavirus-Specific Marker) domain from SARS-CoV-2 | Descriptor: | CHLORIDE ION, GLYCEROL, Papain-like protease nsp3 | Authors: | Stogios, P.J, Skarina, T, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2021-12-20 | Release date: | 2021-12-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the Nsp3 bSM (Betacoronavirus-Specific Marker) domain from SARS-CoV-2 To Be Published
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5TXK
| CRYSTAL STRUCTURE OF USP35 C450S IN COMPLEX WITH UBIQUITIN | Descriptor: | 1,2-ETHANEDIOL, Polyubiquitin-B, SULFATE ION, ... | Authors: | Bader, G, Weiss-Puxbaum, A, Zoephel, A. | Deposit date: | 2016-11-17 | Release date: | 2018-05-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Expansion of DUB functionality generated by alternative isoforms - USP35, a case study. J. Cell. Sci., 131, 2018
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6NW9
| CRYSTAL STRUCTURE OF A TAILSPIKE PROTEIN 3 (TSP3, ORF212) FROM ESCHERICHIA COLI O157:H7 BACTERIOPHAGE CBA120 | Descriptor: | 1,2-ETHANEDIOL, CARBONATE ION, CHLORIDE ION, ... | Authors: | Greenfield, J.Y, Herzberg, O. | Deposit date: | 2019-02-06 | Release date: | 2019-06-05 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure and tailspike glycosidase machinery of ORF212 from E. coli O157:H7 phage CBA120 (TSP3). Sci Rep, 9, 2019
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4YPT
| X-ray structural of three tandemly linked domains of nsp3 from murine hepatitis virus at 2.60 Angstroms resolution | Descriptor: | GLYCEROL, Replicase polyprotein 1ab, ZINC ION | Authors: | Chen, Y, Savinov, S.N, Mielech, A.M, Cao, T, Baker, S.C, Mesecar, A.D. | Deposit date: | 2015-03-13 | Release date: | 2015-08-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.6009 Å) | Cite: | X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions. J.Biol.Chem., 290, 2015
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8AZD
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8AZI
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1LJ2
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8AZC
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8AZL
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8AZN
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8AZM
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8AZP
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8AZO
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8ILC
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8C19
| SARS-CoV-2 NSP3 macrodomain in complex with 1-methyl-4-[5-(morpholin-4-ylcarbonyl)-2-furyl]-1H-pyrrolo[2,3-b]pyridine | Descriptor: | 1,2-ETHANEDIOL, Non-structural protein 3, [5-(1-methylpyrrolo[2,3-b]pyridin-4-yl)furan-2-yl]-morpholin-4-yl-methanone | Authors: | Schuller, M, Ahel, I. | Deposit date: | 2022-12-20 | Release date: | 2023-03-08 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors. Pathogens, 12, 2023
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8C1A
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6W8Z
| Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | Descriptor: | Nonstructural polyprotein, methyl 2-oxo-1,2-dihydroquinazoline-4-carboxylate | Authors: | Zhang, S, Garzan, A, Pathak, A.K, Augelli-Szafran, C.E, Wu, M. | Deposit date: | 2020-03-21 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design. Plos One, 16, 2021
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6W8Y
| Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | Descriptor: | 2-oxo-2,3-dihydropyrimidine-4-carboxylic acid, Nonstructural polyprotein | Authors: | Zhang, S, Garzan, A, Pathak, A.K, Augelli-Szafran, C.E, Wu, M. | Deposit date: | 2020-03-21 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design. Plos One, 16, 2021
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6W91
| Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | Descriptor: | Nonstructural polyprotein, methyl 2-oxo-2,5-dihydropyrimidine-4-carboxylate | Authors: | Zhang, S, Garzan, A, Pathak, A.K, Augelli-Szafran, C.E, Wu, M. | Deposit date: | 2020-03-21 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design. Plos One, 16, 2021
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2M0A
| Solution structure of MHV nsp3a | Descriptor: | Non-structural protein 3 | Authors: | Keane, S.C, Giedroc, D.P. | Deposit date: | 2012-10-23 | Release date: | 2013-01-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of Mouse Hepatitis Virus (MHV) nsp3a and Determinants of the Interaction with MHV Nucleocapsid (N) Protein. J.Virol., 87, 2013
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7PKU
| Structure of SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a | Descriptor: | 3C-like proteinase, Nucleoprotein | Authors: | Bessa, L.M, Guseva, S, Camacho-Zarco, A.R, Salvi, N, Blackledge, M. | Deposit date: | 2021-08-26 | Release date: | 2022-01-19 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a. Sci Adv, 8, 2022
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1XJH
| NMR structure of the redox switch domain of the E. coli Hsp33 | Descriptor: | 33 kDa chaperonin, ZINC ION | Authors: | Won, H.S, Low, L.Y, De Guzman, R.N, Martinez-Yamout, M.A, Jakob, U, Dyson, H.J. | Deposit date: | 2004-09-23 | Release date: | 2004-10-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The Zinc-dependent Redox Switch Domain of the Chaperone Hsp33 has a Novel Fold J.Mol.Biol., 341, 2004
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