5ULV
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![BU of 5ulv by Molmil](/molmil-images/mine/5ulv) | Malate dehydrogenase from Methylobacterium extorquens | Descriptor: | CALCIUM ION, Malate dehydrogenase | Authors: | Gonzalez, J.M. | Deposit date: | 2017-01-25 | Release date: | 2017-02-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Conformational changes on substrate binding revealed by structures of Methylobacterium extorquens malate dehydrogenase. Acta Crystallogr F Struct Biol Commun, 74, 2018
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5A1T
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![BU of 5a1t by Molmil](/molmil-images/mine/5a1t) | Trichomonas vaginalis lactate dehydrogenase in complex with NADH and oxamate | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-LACTATE DEHYDROGENASE, OXAMIC ACID | Authors: | Steindel, P.A, Chen, E.H, Theobald, D.L. | Deposit date: | 2015-05-05 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Gradual Neofunctionalization in the Convergent Evolution of Trichomonad Lactate and Malate Dehydrogenases. Protein Sci., 25, 2016
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3TL2
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![BU of 3tl2 by Molmil](/molmil-images/mine/3tl2) | Crystal structure of Bacillus anthracis str. Ames malate dehydrogenase in closed conformation. | Descriptor: | 1,2-ETHANEDIOL, Malate dehydrogenase, THIOCYANATE ION | Authors: | Blus, B.J, Chruszcz, M, Tkaczuk, K.L, Osinski, T, Cymborowski, M, Kudritska, M, Grimshaw, S, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2011-08-29 | Release date: | 2011-09-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of Bacillus anthracis str. Ames malate dehydrogenase in closed conformation. TO BE PUBLISHED
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7MDH
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![BU of 7mdh by Molmil](/molmil-images/mine/7mdh) | STRUCTURAL BASIS FOR LIGHT ACITVATION OF A CHLOROPLAST ENZYME. THE STRUCTURE OF SORGHUM NADP-MALATE DEHYDROGENASE IN ITS OXIDIZED FORM | Descriptor: | PROTEIN (MALATE DEHYDROGENASE), ZINC ION | Authors: | Johansson, K, Ramaswamy, S, Saarinen, M, Lemaire-Chamley, M, Issakidis-Bourguet, E, Miginiac-Maslow, M, Eklund, H. | Deposit date: | 1999-02-16 | Release date: | 1999-06-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for light activation of a chloroplast enzyme: the structure of sorghum NADP-malate dehydrogenase in its oxidized form. Biochemistry, 38, 1999
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7QOZ
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7M2N
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![BU of 7m2n by Molmil](/molmil-images/mine/7m2n) | Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15 | Descriptor: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid, ... | Authors: | Gumpena, R, Ding, J, Powell, D.A, Lowther, W.T. | Deposit date: | 2021-03-17 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria ACS Medicinal Chemistry Letters, 12, 2021
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7RM9
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![BU of 7rm9 by Molmil](/molmil-images/mine/7rm9) | Human Malate Dehydrogenase I (MDHI) | Descriptor: | MALONATE ION, Malate dehydrogenase, cytoplasmic | Authors: | McCue, W, Finzel, B.C. | Deposit date: | 2021-07-27 | Release date: | 2022-01-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Characterization of the Human Cytosolic Malate Dehydrogenase I. Acs Omega, 7, 2022
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7NAY
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![BU of 7nay by Molmil](/molmil-images/mine/7nay) | Crystal structure of lactate dehydrogenase from Selenomonas ruminantium with NADH. | Descriptor: | 1,2-ETHANEDIOL, BORIC ACID, L-lactate dehydrogenase, ... | Authors: | Bertrand, Q, Robin, A, Girard, E, Madern, D. | Deposit date: | 2021-01-25 | Release date: | 2021-02-10 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases. J.Struct.Biol., 215, 2023
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7RRL
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5HTO
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8Q3C
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![BU of 8q3c by Molmil](/molmil-images/mine/8q3c) | Structure of Selenomonas ruminantium lactate dehydrogenase I85R mutant | Descriptor: | CHLORIDE ION, L-lactate dehydrogenase, NITRATE ION, ... | Authors: | Bertrand, Q, Coquille, S, Iorio, A, Sterpone, F, Madern, D. | Deposit date: | 2023-08-03 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases. J.Struct.Biol., 215, 2023
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8RS5
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8RWL
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![BU of 8rwl by Molmil](/molmil-images/mine/8rwl) | Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 1 | Descriptor: | CHLORIDE ION, GLYCEROL, Malate dehydrogenase, ... | Authors: | Coquille, S, Roche, J, Engilberge, S, Girard, E, Madern, D. | Deposit date: | 2024-02-05 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme. To Be Published
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5HS4
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![BU of 5hs4 by Molmil](/molmil-images/mine/5hs4) | Plasmdoium Vivax Lactate dehydrogenase | Descriptor: | L-lactate dehydrogenase | Authors: | Choi, S.J, Ban, C. | Deposit date: | 2016-01-25 | Release date: | 2016-10-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.339 Å) | Cite: | Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition Sci Rep, 6, 2016
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5HRU
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3VPH
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![BU of 3vph by Molmil](/molmil-images/mine/3vph) | L-lactate dehydrogenase from Thermus caldophilus GK24 complexed with oxamate, NADH and FBP | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, L-lactate dehydrogenase, ... | Authors: | Arai, K, Ohno, T, Miyanaga, A, Fushinobu, S, Taguchi, H. | Deposit date: | 2012-03-01 | Release date: | 2013-03-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The core of allosteric motion in Thermus caldophilus L-lactate dehydrogenase. J.Biol.Chem., 2014
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3VPG
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![BU of 3vpg by Molmil](/molmil-images/mine/3vpg) | L-lactate dehydrogenase from Thermus caldophilus GK24 | Descriptor: | GLYCEROL, L-lactate dehydrogenase | Authors: | Arai, K, Ohno, T, Miyanaga, A, Fushinobu, S, Taguchi, H. | Deposit date: | 2012-03-01 | Release date: | 2013-03-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The core of allosteric motion in Thermus caldophilus L-lactate dehydrogenase. J.Biol.Chem., 2014
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6OR9
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6P6U
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![BU of 6p6u by Molmil](/molmil-images/mine/6p6u) | |
6PBL
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6Q0D
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![BU of 6q0d by Molmil](/molmil-images/mine/6q0d) | CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00384414-01 AT 2.05 A RESOLUTION | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-[3-(cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, GLYCEROL, ... | Authors: | Dranow, D.M, Davies, D.R. | Deposit date: | 2019-08-01 | Release date: | 2020-09-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J.Med.Chem., 63, 2020
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6ZZR
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![BU of 6zzr by Molmil](/molmil-images/mine/6zzr) | The Crystal Structure of human LDHA from Biortus. | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, L-lactate dehydrogenase A chain | Authors: | Wang, F, Lin, D, Cheng, W, Bao, X, Zhu, B, Shang, H. | Deposit date: | 2020-08-05 | Release date: | 2020-08-19 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The Crystal Structure of human LDHA from Biortus To Be Published
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2A92
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![BU of 2a92 by Molmil](/molmil-images/mine/2a92) | Crystal structure of lactate dehydrogenase from Plasmodium vivax: complex with NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase | Authors: | Chaikuad, A, Fairweather, V, Conners, R, Joseph-Horne, T, Turgut-Balik, D, Brady, R.L. | Deposit date: | 2005-07-11 | Release date: | 2006-01-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH. Biochemistry, 44, 2005
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2LDX
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2A94
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![BU of 2a94 by Molmil](/molmil-images/mine/2a94) | Structure of Plasmodium falciparum lactate dehydrogenase complexed to APADH. | Descriptor: | ACETYL PYRIDINE ADENINE DINUCLEOTIDE, REDUCED, L-lactate dehydrogenase | Authors: | Chaikuad, A, Fairweather, V, Conners, R, Joseph-Horne, T, Turgut-Balik, D, Brady, R.L. | Deposit date: | 2005-07-11 | Release date: | 2006-01-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH. Biochemistry, 44, 2005
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