5D6N
 
 | | Crystal structure of a mycobacterial protein | | Descriptor: | Acyl-CoA synthase | | Authors: | Li, W.J, Bi, L.J. | | Deposit date: | 2015-08-12 | | Release date: | 2016-03-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria.
Sci Rep, 5, 2015
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5BQS
 | | S. Pneumoniae Fabh with small molecule inhibitor 4 | | Descriptor: | 1-{5-[2-chloro-5-(hydroxymethyl)phenyl]pyridin-2-yl}piperidine-4-carboxylic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 3, SODIUM ION | | Authors: | Kazmirski, S.L, McKinney, D.C. | | Deposit date: | 2015-05-29 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.
Acs Infect Dis., 2, 2016
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2K92
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2K94
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2K93
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7VEF
 | | The structure of GfsA KSQ-AT didomain in complex with a malonate substrate analog | | Descriptor: | GLYCEROL, N-(2-acetamidoethyl)-2-nitro-ethanamide, Polyketide synthase | | Authors: | Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T. | | Deposit date: | 2021-09-08 | | Release date: | 2022-01-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases.
Acs Chem.Biol., 17, 2022
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7VEE
 | | The ligand-free structure of GfsA KSQ-AT didomain | | Descriptor: | GLYCEROL, Polyketide synthase | | Authors: | Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T. | | Deposit date: | 2021-09-08 | | Release date: | 2022-01-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases.
Acs Chem.Biol., 17, 2022
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3FK5
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3T5Y
 | | Crystal structure of CerJ from Streptomyces tendae - malonic acid covalently linked to the catalytic Cystein C116 | | Descriptor: | ACETATE ION, CerJ | | Authors: | Zocher, G, Bretschneider, T, Hertweck, C, Stehle, T. | | Deposit date: | 2011-07-28 | | Release date: | 2011-12-21 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis.
Nat.Chem.Biol., 8, 2011
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7CPX
 | | Lovastatin nonaketide synthase | | Descriptor: | Lovastatin nonaketide synthase, polyketide synthase component, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Wang, J, Wang, Z. | | Deposit date: | 2020-08-08 | | Release date: | 2021-01-13 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Structural basis for the biosynthesis of lovastatin.
Nat Commun, 12, 2021
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7ZSK
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7NXG
 | | Wax synthase 1 from Acinetobacter baylyi (AbWSD1) co-crystallized with myristic acid | | Descriptor: | MYRISTIC ACID, O-acyltransferase WSD | | Authors: | Vollheyde, K, Kuehnel, K, Lambrecht, F, Kawelke, S, Herrfurth, C, Feussner, I. | | Deposit date: | 2021-03-18 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of the Bifunctional Wax Synthase 1 from Acinetobacter baylyi Suggests a Conformational Change upon Substrate Binding and Formation of Additional Substrate Binding Sites
Acs Catalysis, 12, 2022
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8HTA
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5VXF
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5VXH
 | | Crystal structure of Xanthomonas campestris OleA E117D | | Descriptor: | 3-oxoacyl-[ACP] synthase III, GLYCEROL, PHOSPHATE ION | | Authors: | Jensen, M.R, Wilmot, C.M. | | Deposit date: | 2017-05-23 | | Release date: | 2017-10-25 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | OleA Glu117 is key to condensation of two fatty-acyl coenzyme A substrates in long-chain olefin biosynthesis.
Biochem. J., 474, 2017
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3EUQ
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2VQD
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5MY2
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7TUI
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3NFD
 | | Chronobacterium ammoniagenes ACPS-CoA complex | | Descriptor: | COENZYME A, Phosphopantetheine protein transferase, Ppt1p | | Authors: | Gokulan, K. | | Deposit date: | 2010-06-10 | | Release date: | 2011-01-05 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.
Acta Crystallogr.,Sect.D, 67, 2011
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3NE9
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5NJI
 | | Structure of the dehydratase domain of PpsC from Mycobacterium tuberculosis in complex with C12:1-CoA | | Descriptor: | Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsC, ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{E})-dodec-2-enethioate | | Authors: | Gavalda, S, Faille, A, Mourey, L, Pedelacq, J.D. | | Deposit date: | 2017-03-28 | | Release date: | 2017-05-31 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
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3O04
 | | Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes | | Descriptor: | beta-keto-acyl carrier protein synthase II | | Authors: | Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2010-07-19 | | Release date: | 2010-08-04 | | Last modified: | 2021-10-06 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes
To be Published
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3STX
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3STY
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