Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6E2O
DownloadVisualize
BU of 6e2o by Molmil
ASK1 kinase domain complex with inhibitor
Descriptor: 4-(4-cyclopropyl-1H-imidazol-1-yl)-N-[3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide, Mitogen-activated protein kinase kinase kinase 5
Authors:Lansdon, E.B.
Deposit date:2018-07-11
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.389 Å)
Cite:ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
J. Clin. Invest., 128, 2018
3L0D
DownloadVisualize
BU of 3l0d by Molmil
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Bartonella henselae with bound NAD
Descriptor: Glyceraldehyde 3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-12-09
Release date:2009-12-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Bartonella henselae with bound NAD
To be Published
5JOH
DownloadVisualize
BU of 5joh by Molmil
CRYSTAL STRUCTURE OF CSN5(2-257) IN COMPLEX WITH CNS5i-1b
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2'-chloro-6-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-carbonitrile, COP9 signalosome complex subunit 5, ...
Authors:Renatus, M, Wiesmann, C.
Deposit date:2016-05-02
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Targeted inhibition of the COP9 signalosome for treatment of cancer.
Nat Commun, 7, 2016
3L81
DownloadVisualize
BU of 3l81 by Molmil
Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)
Descriptor: AP-4 complex subunit mu-1, Amyloid beta A4 protein, GLYCEROL
Authors:Mardones, G.A, Rojas, A.L, Burgos, P.V, Dasilva, L.L.P, Prabhu, Y, Bonifacino, J.S, Hurley, J.H.
Deposit date:2009-12-29
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.
Dev.Cell, 18, 2010
3LV0
DownloadVisualize
BU of 3lv0 by Molmil
Crystal structure of extragenic suppressor protein suhB from Bartonella henselae, native
Descriptor: Extragenic suppressor protein suhB, MAGNESIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-02-18
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of extragenic suppressor protein suhB from Bartonella henselae
To be Published
6EPN
DownloadVisualize
BU of 6epn by Molmil
Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F2
Descriptor: 1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-ethanone, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V.
Deposit date:2017-10-12
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
4WSN
DownloadVisualize
BU of 4wsn by Molmil
Crystal structure of the COP9 signalosome, a P1 crystal form
Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Bunker, R.D, Lingaraju, G.M, Thoma, N.H.
Deposit date:2014-10-28
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Nature, 531, 2016
5LKS
DownloadVisualize
BU of 5lks by Molmil
Structure-function insights reveal the human ribosome as a cancer target for antibiotics
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Myasnikov, A.G, Natchiar, S.K, Nebout, M, Hazemann, I, Imbert, V, Khatter, H, Peyron, J.-F, Klaholz, B.P.
Deposit date:2016-07-23
Release date:2017-04-26
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Nat Commun, 7, 2016
1X95
DownloadVisualize
BU of 1x95 by Molmil
Solution structure of the DNA-hexamer ATGCAT complexed with DNA Bis-intercalating Anticancer Drug XR5944 (MLN944)
Descriptor: 1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM, 5'-D(*AP*TP*GP*CP*AP*T)-3'
Authors:Dai, J, Punchihewa, C, Mistry, P, Ooi, A.T, Yang, D.
Deposit date:2004-08-19
Release date:2004-09-28
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug.
J.Biol.Chem., 279, 2004
1X67
DownloadVisualize
BU of 1x67 by Molmil
Solution structure of the cofilin homology domain of HIP-55 (drebrin-like protein)
Descriptor: Drebrin-like protein
Authors:Goroncy, A.K, Kigawa, T, Koshiba, S, Sato, M, Kobayashi, N, Tochio, N, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-17
Release date:2005-11-17
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:NMR solution structures of actin depolymerizing factor homology domains.
Protein Sci., 18, 2009
1Z3Q
DownloadVisualize
BU of 1z3q by Molmil
Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A
Descriptor: 1,2-ETHANEDIOL, Thaumatin-like Protein
Authors:Leone, P, Menu-Bouaouiche, L, Peumans, W.J, Barre, A, Payan, F, Roussel, A, Van Damme, E.J.M, Rouge, P.
Deposit date:2005-03-14
Release date:2006-01-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-A
Biochimie, 88, 2006
5M5Q
DownloadVisualize
BU of 5m5q by Molmil
COPS5(2-257) IN COMPLEX WITH A AZAINDOLE (COMPOUND 4)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-[(3~{R})-3-(1~{H}-benzimidazol-2-yl)morpholin-4-yl]-3-[2-(4-methyl-2-phenyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]propan-1-one, COP9 signalosome complex subunit 5, ...
Authors:Renatus, M, Altmann, E.
Deposit date:2016-10-22
Release date:2017-01-11
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
Angew. Chem. Int. Ed. Engl., 56, 2017
5NUZ
DownloadVisualize
BU of 5nuz by Molmil
Junin virus GP1 glycoprotein in complex with an antibody Fab fragment
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Zeltina, A, Krumm, S.A, Sahin, M, Struwe, W.B, Harlos, K, Nunberg, J.H, Crispin, M, Pinschewer, D.D, Doores, K.J, Bowden, T.A.
Deposit date:2017-05-03
Release date:2017-06-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5O8K
DownloadVisualize
BU of 5o8k by Molmil
Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895
Descriptor: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Emamzadah, S, Tropia, L, Huber, F, Halazonetis, T.
Deposit date:2017-06-13
Release date:2018-06-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895
To Be Published
5OA3
DownloadVisualize
BU of 5oa3 by Molmil
Human 40S-eIF2D-re-initiation complex
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Weisser, M, Schaefer, T, Leibundgut, M, Boehringer, D, Aylett, C.H.S, Ban, N.
Deposit date:2017-06-20
Release date:2017-08-09
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural and Functional Insights into Human Re-initiation Complexes.
Mol. Cell, 67, 2017
5OVD
DownloadVisualize
BU of 5ovd by Molmil
Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in new crystal form
Descriptor: 1,2-ETHANEDIOL, Son of sevenless homolog 1
Authors:Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V.
Deposit date:2017-08-28
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6QZP
DownloadVisualize
BU of 6qzp by Molmil
High-resolution cryo-EM structure of the human 80S ribosome
Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ...
Authors:Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P.
Deposit date:2019-03-12
Release date:2019-04-24
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Visualization of chemical modifications in the human 80S ribosome structure.
Nature, 551, 2017
6R7F
DownloadVisualize
BU of 6r7f by Molmil
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Faull, S.V, Lau, A.M.C, Martens, C, Ahdash, Z, Yebenes, H, Schmidt, C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A.
Deposit date:2019-03-28
Release date:2019-08-28
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R7S
DownloadVisualize
BU of 6r7s by Molmil
Human Serum Albumin, complexed with Sulfasalazine
Descriptor: 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Schreuder, H.A, Liesum, A.
Deposit date:2019-03-29
Release date:2020-04-08
Last modified:2020-05-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Resolving Binding Events on the Multifunctional Human Serum Albumin.
Chemmedchem, 15, 2020
7LUO
DownloadVisualize
BU of 7luo by Molmil
N-terminus of Skp2 bound to Cyclin A
Descriptor: S-phase kinase-associated protein 2,Cyclin-A2, Skp2 Motif 1 uncharacterized fragment 1, Skp2 Motif 1 uncharacterized fragment 2
Authors:Kelso, S, Ceccarelli, D.F, Sicheri, F.
Deposit date:2021-02-22
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Bipartite binding of the N terminus of Skp2 to cyclin A.
Structure, 29, 2021
6R7H
DownloadVisualize
BU of 6r7h by Molmil
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Faull, S.V, Lau, A.M.C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A.
Deposit date:2019-03-28
Release date:2019-08-28
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (8.8 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R7I
DownloadVisualize
BU of 6r7i by Molmil
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Faull, S.F, Lau, A.M.C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A.
Deposit date:2019-03-28
Release date:2019-08-28
Last modified:2019-09-04
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R55
DownloadVisualize
BU of 6r55 by Molmil
Crystal structure of PPEP-1(E184K)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION
Authors:Pichlo, C, Baumann, U.
Deposit date:2019-03-24
Release date:2019-06-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
J.Biol.Chem., 294, 2019
6R6H
DownloadVisualize
BU of 6r6h by Molmil
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Morris, E.P, Faull, S.V, Lau, A.M.C, Politis, A, Beuron, F, Cronin, N.
Deposit date:2019-03-27
Release date:2019-08-28
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (8.4 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R52
DownloadVisualize
BU of 6r52 by Molmil
Crystal structure of PPEP-1(K101A)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION
Authors:Pichlo, C, Baumann, U.
Deposit date:2019-03-24
Release date:2019-06-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.022 Å)
Cite:Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
J.Biol.Chem., 294, 2019

221051

건을2024-06-12부터공개중

PDB statisticsPDBj update infoContact PDBjnumon