2HWY
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2HWZ
| Fab fragment of Humanized anti-viral antibody MEDI-493 (Synagis TM) | Descriptor: | Immunoglobulin Fab heavy chain, Immunoglobulin Fab light chain | Authors: | Braden, B. | Deposit date: | 2006-08-02 | Release date: | 2007-08-14 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification of a single tryptophan residue as critical for binding activity in a humanized monoclonal antibody against respiratory syncytial virus To be Published
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2HX0
| Three-dimensional structure of the hypothetical protein from Salmonella cholerae-suis (aka Salmonella enterica) at the resolution 1.55 A. Northeast Structural Genomics target ScR59. | Descriptor: | MAGNESIUM ION, Putative DNA-binding protein | Authors: | Kuzin, A.P, Abashidze, M, Seetharaman, J, Shastry, R, Conover, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-08-02 | Release date: | 2006-09-19 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Three-dimensional structure of the hypothetical protein from Salmonella cholerae-suis (aka Salmonella enterica) at the resolution 1.55 A. Northeast Structural Genomics target ScR59. To be Published
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2HX1
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2HX2
| Bovine eNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine | Descriptor: | (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)(HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | Authors: | Igarashi, J, Li, H, Poulos, T.L. | Deposit date: | 2006-08-02 | Release date: | 2007-04-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50, 2007
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2HX3
| Rat nNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine | Descriptor: | (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)(HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | Authors: | Igarashi, J, Li, H, Poulos, T.L. | Deposit date: | 2006-08-02 | Release date: | 2007-04-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50, 2007
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2HX4
| Rat nNOS heme domain complexed with 4-N-(Nw-nitro-L-argininyl)-trans-4-hydroxyamino-L-proline amide | Descriptor: | (4R)-4-(HYDROXY{N~5~-[IMINO(NITROAMINO)METHYL]-L-ORNITHYL}AMINO)-L-PROLINAMIDE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | Authors: | Igarashi, J, Li, H, Poulos, T.L. | Deposit date: | 2006-08-02 | Release date: | 2007-04-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50, 2007
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2HX5
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2HX6
| Solution structure analysis of the phage T4 endoribonuclease RegB | Descriptor: | Ribonuclease | Authors: | Odaert, B, Saida, F, Uzan, M, Bontems, F. | Deposit date: | 2006-08-02 | Release date: | 2006-10-31 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural and functional studies of RegB, a new member of a family of sequence-specific ribonucleases involved in mRNA inactivation on the ribosome. J.Biol.Chem., 282, 2007
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2HX7
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2HX8
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2HX9
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2HXA
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2HXB
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2HXC
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2HXD
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2HXF
| KIF1A head-microtubule complex structure in amppnp-form | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Kikkawa, M, Hirokawa, N. | Deposit date: | 2006-08-03 | Release date: | 2006-10-10 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations Embo J., 25, 2006
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2HXG
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2HXH
| KIF1A head-microtubule complex structure in adp-form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Kikkawa, M, Hirokawa, N. | Deposit date: | 2006-08-03 | Release date: | 2006-10-10 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (11 Å) | Cite: | High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations Embo J., 25, 2006
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2HXI
| Structural Genomics, the crystal structure of a putative transcriptional regulator from Streptomyces coelicolor A3(2) | Descriptor: | Putative transcriptional regulator | Authors: | Tan, K, Xu, X, Zheng, H, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2006-08-03 | Release date: | 2006-09-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The crystal structure of a putative transcriptional regulator TetR from Streptomyces coelicolor A3(2) To be Published
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2HXK
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2HXL
| crystal structure of Chek1 in complex with inhibitor 1 | Descriptor: | 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE, Serine/threonine-protein kinase Chk1 | Authors: | Yan, Y. | Deposit date: | 2006-08-03 | Release date: | 2007-06-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
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2HXM
| Complex of UNG2 and a small Molecule synthetic Inhibitor | Descriptor: | 4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID, Uracil-DNA glycosylase | Authors: | Bianchet, M.A, Krosky, D.J, Ghung, S, Seiple, L, Amzel, L.M, Stivers, J.T. | Deposit date: | 2006-08-03 | Release date: | 2006-12-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Mimicking damaged DNA with a small molecule inhibitor of human UNG2. Nucleic Acids Res., 34, 2006
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2HXO
| Structure of the transcriptional regulator SCO7222, a TetR from Streptomyces coelicolor | Descriptor: | Putative TetR-family transcriptional regulator | Authors: | Singer, A.U, Skarina, T, Zhang, R.G, Onopriyenko, O, Edwards, A.M, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2006-08-03 | Release date: | 2006-08-22 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the transcriptional regulator SCO7222, a TetR from Streptomyces coelicolor To be Published
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2HXP
| Crystal Structure of the human phosphatase (DUSP9) | Descriptor: | Dual specificity protein phosphatase 9, PHOSPHATE ION | Authors: | Madegowda, M, Eswaramoorthy, S, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-08-03 | Release date: | 2006-08-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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