PDB: 13413 resultsInfo pagesStatus searchChemie searchBIRD

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1R6A	Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate Descriptor: Genome polyprotein, RIBAVIRIN MONOPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Benarroch, D, Egloff, M.P, Mulard, L, Romette, J.L, Canard, B. Deposit date: 2003-10-15 Release date: 2004-09-21 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate. J.Biol.Chem., 279, 2004
6BSH	Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode Descriptor: (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, CALCIUM ION, DNA (5'-D(*GP*TP*AP*TP*GP*CP*CP*AP*CP*TP*AP*GP*TP*TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3'), ... Authors: Tian, L, Kim, M, Yang, W. Deposit date: 2017-12-03 Release date: 2018-01-03 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.649 Å) Cite: Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3ISC	Binary complex of human DNA polymerase beta with an abasic site (THF) in the gapped DNA Descriptor: 5'-D(*CP*CP*GP*AP*CP*(3DR)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... Authors: Beard, W.A, Shock, D.D, Batra, V.K, Pedersen, L.C, Wilson, S.H. Deposit date: 2009-08-25 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". J.Biol.Chem., 284, 2009
1O0B	CRYSTAL STRUCTURE OF L-GLUTAMINE AND AMPCPP BOUND TO GLUTAMINE AMINOACYL TRNA SYNTHETASE Descriptor: ADENOSINE MONOPHOSPHATE, GLUTAMINE, Glutaminyl tRNA, ... Authors: Bullock, T.L, Perona, J.J. Deposit date: 2003-02-20 Release date: 2003-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Amino Acid Discrimination by a class I aminoacyl-tRNA synthetase specified by negative determinants J.Mol.Biol., 328, 2003
6BSJ	Structure of HIV-1 RT complexed with an RNA/DNA hybrid sequence non-preferred for RNA hydrolysis Descriptor: (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, CALCIUM ION, DNA (5'-D(*GP*TP*AP*TP*GP*CP*CP*TP*AP*TP*AP*GP*TP*TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3'), ... Authors: Tian, L, Kim, M, Yang, W. Deposit date: 2017-12-03 Release date: 2018-01-03 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BSI	Structure of HIV-1 RT complexed with an RNA/DNA hybrid containing the polypurine-tract sequence Descriptor: (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, CALCIUM ION, DNA (5'-D(*GP*TP*TP*TP*TP*TP*CP*TP*TP*TP*TP*GP*TP*TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3'), ... Authors: Tian, L, Kim, M, Yang, W. Deposit date: 2017-12-03 Release date: 2018-01-03 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3ISB	Binary complex of human DNA polymerase beta with a gapped DNA Descriptor: 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... Authors: Beard, W.A, Shock, D.D, Batra, V.K, Pedersen, L.C, Wilson, S.H. Deposit date: 2009-08-25 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". J.Biol.Chem., 284, 2009
3N89	KH domains Descriptor: Defective in germ line development protein 3, isoform a Authors: Nakel, K, Hartung, S.A, Bonneau, F, Eckmann, C.R, Conti, E. Deposit date: 2010-05-28 Release date: 2010-09-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.789 Å) Cite: Four KH domains of the C. elegans Bicaudal-C ortholog GLD-3 form a globular structural platform. Rna, 16, 2010
1O0C	CRYSTAL STRUCTURE OF L-GLUTAMATE AND AMPCPP BOUND TO GLUTAMINE AMINOACYL TRNA SYNTHETASE Descriptor: ADENOSINE MONOPHOSPHATE, GLUTAMIC ACID, Glutaminyl tRNA, ... Authors: Bullock, T.L, Perona, J.J. Deposit date: 2003-02-20 Release date: 2003-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Amino Acid Discrimination by a class I aminoacyl-tRNA synthetase specified by negative determinants J.Mol.Biol., 328, 2003
3PGL	Crystal structure of human small C-terminal domain phosphatase 1 (Scp1) bound to rabeprazole Descriptor: 2-[(R)-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl]-1H-benzimidazole, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, MAGNESIUM ION Authors: Zhang, M, Cho, E.J, Burstein, G, Siegel, D, Zhang, Y. Deposit date: 2010-11-02 Release date: 2011-03-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor. Acs Chem.Biol., 6, 2011
4IUU	Crystal structure of SHH1 SAWADEE domain in complex with H3K9me1 peptide Descriptor: CYMAL-4, Histone H3.2, H3(1-15)K9me3, ... Authors: Du, J, Patel, D.J. Deposit date: 2013-01-21 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature, 498, 2013
4IUR	crystal structure of SHH1 SAWADEE domain in complex with H3K9me3 peptide Descriptor: CYMAL-4, Histone H3.2, H3(1-15)K9me3, ... Authors: Patel, D.J, Du, J. Deposit date: 2013-01-21 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.501 Å) Cite: Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature, 498, 2013
4IUV	crystal structure of SHH1 SAWADEE domain in complex with H3K4me1K9me1 peptide Descriptor: CYMAL-4, Histone H3.2, H3(1-15)K9me3, ... Authors: Du, J, Patel, D.J. Deposit date: 2013-01-21 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature, 498, 2013
4IUT	crystal structure of SHH1 SAWADEE domain in complex with H3K9me2 peptide Descriptor: CYMAL-4, Histone H3.2, H3(1-15)K9me3, ... Authors: Du, J, Patel, D.J. Deposit date: 2013-01-21 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature, 498, 2013
1WCN	NMR structure of the carboxyterminal domains of Escherichia coli NusA Descriptor: TRANSCRIPTION ELONGATION PROTEIN NUSA Authors: Eisenmann, A, Schwarz, S, Schweimer, K, Roesch, P. Deposit date: 2004-11-18 Release date: 2005-08-31 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The E. Coli Nusa Carboxy-Terminal Domains are Structurally Similar and Show Specific Rnap- and Lambdan Interactions Protein Sci., 14, 2005
5WEA	Human Argonaute2 Helix-7 Mutant Descriptor: PHENOL, Protein argonaute-2, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*U)-3') Authors: Schirle, N.T, Klum, S.M, MacRae, I.J. Deposit date: 2017-07-08 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.12 Å) Cite: Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition. EMBO J., 37, 2018
5TB9	Precatalytic ternary complex of Human DNA Polymerase Beta in closed conformation With Gapped DNA substrate incoming (-)FTC-TP and Mn2+. Descriptor: 10- MER PRIMER, 16- MER TEMPLATE, 5-MER PHOSPHORYLATED DOWNSTREAM PRIMER, ... Authors: Vyas, R, Suo, Z. Deposit date: 2016-09-11 Release date: 2017-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase. J. Am. Chem. Soc., 139, 2017
5TBB	Postcatalytic ternary complex of Human DNA Polymerase Beta with Gapped DNA substrate, incorporated (-)FTC and PPi. Descriptor: 10- MER PRIMER, 16- MER TEMPLATE, 5-MER PHOSPHORYLATED DOWNSTREAM PRIMER, ... Authors: Vyas, R, Suo, Z. Deposit date: 2016-09-11 Release date: 2017-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase. J. Am. Chem. Soc., 139, 2017
5TBA	Postcatalytic ternary complex of Human DNA Polymerase Beta with Gapped DNA substrate, incorporated (-)3TC and PPi. Descriptor: 10-MER PRIMER, 16-MER TEMPLATE, 5-MER PHOSPHORYLATED DOWNSTREAM PRIMER, ... Authors: Vyas, R, Suo, Z. Deposit date: 2016-09-11 Release date: 2017-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase. J. Am. Chem. Soc., 139, 2017
6XP5	Head-Middle module of Mediator Descriptor: HEAT, Med22, Mediator of RNA polymerase II transcription subunit 1, ... Authors: Zhang, H.Q, Chen, D.C, Kornberg, R.D. Deposit date: 2020-07-08 Release date: 2021-03-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Mediator structure and conformation change. Mol.Cell, 81, 2021
4R64	Binary complex crystal structure of E295K mutant of DNA polymerase Beta Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... Authors: Batra, V.K, Beard, W.A, Wilson, S.H. Deposit date: 2014-08-22 Release date: 2014-10-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Substrate-induced DNA Polymerase beta Activation. J.Biol.Chem., 289, 2014
8CTF	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid Descriptor: 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... Authors: Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. Deposit date: 2022-05-14 Release date: 2022-12-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
5UJ2	Crystal structure of HCV NS5B genotype 2A JFH-1 isolate with S15G E86Q E87Q C223H V321I mutations and Delta8 neta hairpoin loop deletion in complex with GS-639476 (diphsohate version of GS-9813), Mn2+ and symmetrical primer template 5'-AUAAAUUU Descriptor: (1S)-1-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-1,4-anhydro-2-deoxy-2-fluoro-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-2-methyl-D-ribitol, CHLORIDE ION, Genome polyprotein, ... Authors: Edwards, T.E, Fox III, D, Appleby, T.C, Murakami, E, Rey, A, McGrath, M.E. Deposit date: 2017-01-16 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties. Bioorg. Med. Chem. Lett., 27, 2017
7TO2	Cryo-EM structure of RIG-I bound to the internal sites of p3SLR30 (+ATP) Descriptor: ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, MAGNESIUM ION, ... Authors: Wang, W, Pyle, A.M. Deposit date: 2022-01-22 Release date: 2022-11-02 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
8DDB	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinic acid Descriptor: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... Authors: Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. Deposit date: 2022-06-17 Release date: 2022-12-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023

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