PDB: 46164 resultsInfo pagesStatus searchChemie searchBIRD

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7OB5	Crystal structure of 14-3-3 sigma in complex with LDB1 phosphopeptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBX	Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBT	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBY	Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-24 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBK	Crystal structure of 14-3-3 sigma in complex with PKR phosphopeptide Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, PKR phosphopeptide Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBL	Crystal structure of 14-3-3 sigma in complex with PKR phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, FUSICOCCIN, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBH	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBS	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap Descriptor: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION Authors: Fiorillo, A, Ilari, A. Deposit date: 2015-05-08 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
3IQU	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) Descriptor: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
3IQV	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin Descriptor: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
7NIF	14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-011 Descriptor: 1-(4-methylphenyl)imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. Deposit date: 2021-02-12 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7NSV	14-3-3 sigma with p65 (RelA) binding site pS45 and covalently bound PC2046 Descriptor: 1-(3-bromanyl-4-methyl-phenyl)-2-(2-bromophenyl)imidazole, 14-3-3 protein sigma, GLYCEROL, ... Authors: Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. Deposit date: 2021-03-08 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.33 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
6Y7T	Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding Descriptor: 14-3-3 protein sigma, ExoSTWZ molecular tweezer, Exoenzyme S, ... Authors: Guillory, X, Ottmann, C. Deposit date: 2020-03-02 Release date: 2021-03-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand. J.Am.Chem.Soc., 143, 2021
6BYL	Structure of 14-3-3 gamma bound to O-GlcNAcylated thr peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSASTTVPVTTATTTTTSTW O-GlcNac peptide Authors: Schumacher, M.A. Deposit date: 2017-12-20 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
7D8P	CRTC1 pSer151 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer151 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
6BYJ	Structure of human 14-3-3 gamma bound to O-GlcNAc peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSTTATPPVSQASSTTTSTW O-GlcNac peptide Authors: Schumacher, M.A. Deposit date: 2017-12-20 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
6BYK	Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide Descriptor: 14-3-3 protein beta/alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose, ATPPVSQASSTT O-GlcNac peptide Authors: Schumacher, M.A. Deposit date: 2017-12-20 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
5BY9	The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2015-06-10 Release date: 2016-04-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (4 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
8TKF	Human Type 3 IP3 Receptor - Activated State (+IP3/ATP/JD Ca2+) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... Authors: Paknejad, N, Sapuru, V, Hite, R.K. Deposit date: 2023-07-25 Release date: 2023-11-08 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor. Nat Commun, 14, 2023
7PWZ	Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228 Descriptor: 14-3-3 protein sigma, 2-oxidanyl-5-[(2~{R})-4-oxidanyl-5-oxidanylidene-2-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]benzoic acid, C-terminus of Estrogen receptor alpha, ... Authors: Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. Deposit date: 2021-10-07 Release date: 2022-12-21 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
7NNE	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 22 Descriptor: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NN2	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 41 Descriptor: 14-3-3 protein sigma, 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMW	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 40 Descriptor: 14-3-3 protein sigma, 5-(2-azanylethyl)-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NP2	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CHLORIDE ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022

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