6FN9

Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins

Summary for 6FN9

• Entry DOI: 10.2210/pdb6fn9/pdb
• Related: 3T0M 4IHL
• Descriptor: 14-3-3 protein zeta/delta, [2-[2-oxidanylidene-2-[[3-[2-[2-[2-[3-oxidanylidene-3-(propylamino)propoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]amino]ethoxy]phenyl]phosphonic acid, BENZOIC ACID, ... (5 entities in total)
• Functional Keywords: inhibition, mono- and bivalent 14-3-3 inhibitors, supramolecular lysine-peg, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 54253.11

Authors

Bier, D.,Ottmann, C. (deposition date: 2018-02-02, release date: 2018-07-04, Last modification date: 2018-12-19)

• Primary citation: Yilmaz, E.,Bier, D.,Guillory, X.,Briels, J.,Ruiz-Blanco, Y.B.,Sanchez-Garcia, E.,Ottmann, C.,Kaiser, M.; Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins.; Chemistry, 24:13807-13814, 2018; PubMed: 29924885; DOI: 10.1002/chem.201801074

Experimental method

X-RAY DIFFRACTION (2.27 Å)