3HRS
| Crystal Structure of the Manganese-activated Repressor ScaR: apo form | Descriptor: | Metalloregulator ScaR, SULFATE ION | Authors: | Stoll, K.E, Draper, W.E, Kliegman, J.I, Golynskiy, M.V, Brew-Appiah, R.A.T, Brown, H.K, Breyer, W.A, Jakubovics, N.S, Jenkinson, H.F, Brennan, R.B, Cohen, S.M, Glasfeld, A. | Deposit date: | 2009-06-09 | Release date: | 2009-06-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Characterization and structure of the manganese-responsive transcriptional regulator ScaR. Biochemistry, 48, 2009
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3R8I
| Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86) | Descriptor: | 2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]ethyl}phenoxy)-2-methylpropanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Loiodice, F, Laghezza, A, Fracchiolla, G, Lavecchia, A, Novellino, E, Crestani, M. | Deposit date: | 2011-03-24 | Release date: | 2012-01-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. J.Med.Chem., 55, 2012
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4HGA
| Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX | Descriptor: | Death domain-associated protein 6, Histone H3.3, Histone H4, ... | Authors: | Liu, C.P, Xiong, C.Y, Wang, M.Z, Yu, Z.L, Yang, N, Chen, P, Zhang, Z.G, Li, G.H, Xu, R.M. | Deposit date: | 2012-10-07 | Release date: | 2012-11-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.799 Å) | Cite: | Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nat.Struct.Mol.Biol., 19, 2012
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2MT4
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7FF4
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1OT3
| Crystal structure of Drosophila deoxyribonucleotide kinase complexed with the substrate deoxythymidine | Descriptor: | Deoxyribonucleoside Kinase, SULFATE ION, THYMIDINE | Authors: | Mikkelsen, N.E, Johansson, K, Karlsson, A, Knecht, W, Andersen, G, Piskur, J, Munch-Petersen, B, Eklund, H. | Deposit date: | 2003-03-21 | Release date: | 2003-05-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Feedback Inhibition of the Deoxyribonucleoside Salvage Pathway: Studies of the Drosophila Deoxyribonucleoside Kinase. Biochemistry, 42, 2003
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3AMU
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2KWP
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3EMT
| Crystal structure of the mimivirus NDK +Kpn-R107G double mutant complexed with dGDP | Descriptor: | 2'-DEOXYGUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside diphosphate kinase | Authors: | Jeudy, S, Lartigue, A, Claverie, J.M, Abergel, C. | Deposit date: | 2008-09-25 | Release date: | 2009-08-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Dissecting the unique nucleotide specificity of mimivirus nucleoside diphosphate kinase. J.Virol., 83, 2009
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6X49
| Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ649), a Non-nucleoside Inhibitor | Descriptor: | 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile, Reverse transcriptase/ribonuclease H, SULFATE ION, ... | Authors: | Chan, A.H, Duong, V.N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S. | Deposit date: | 2020-05-22 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.745 Å) | Cite: | Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. Protein Sci., 29, 2020
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6X4F
| Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with methyl 2-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acetate (JLJ681), a Non-nucleoside Inhibitor | Descriptor: | Reverse transcriptase/ribonuclease H, SULFATE ION, methyl (6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)acetate, ... | Authors: | Chan, A.H, Duong, V.N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S. | Deposit date: | 2020-05-22 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. Protein Sci., 29, 2020
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3WJ5
| Crystal structure of PPARgamma ligand binding domain in complex with triphenyltin | Descriptor: | Peroxisome proliferator-activated receptor gamma, triphenylstannanyl | Authors: | Harada, S, Hiromori, Y, Fukakusa, S, Kawahara, K, Nakamura, S, Noda, M, Uchiyama, S, Fukui, K, Nishikawa, J, Nagase, H, Kobayashi, Y, Ohkubo, T, Yoshida, T, Nakanishi, T. | Deposit date: | 2013-10-04 | Release date: | 2014-10-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds To be Published
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3EF7
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3EDW
| Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability | Descriptor: | SULFATE ION, Thymidylate synthase | Authors: | Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. | Deposit date: | 2008-09-03 | Release date: | 2010-03-02 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
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7BO7
| CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437 | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-[(4~{a}~{S},7~{a}~{S})-4-azanyl-1,4,4~{a},7~{a}-tetrahydropyrrolo[2,3-d]pyrimidin-7-yl]-5-(quinolin-7-yloxymethyl)oxolane-3,4-diol, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Brown, D, Robinson, C, Carr, K.H, Pande, V. | Deposit date: | 2021-01-24 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437 To Be Published
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3E25
| Crystal structure of M. tuberculosis glucosyl-3-phosphoglycerate synthase | Descriptor: | 3-PHOSPHOGLYCERIC ACID, MAGNESIUM ION, Putative uncharacterized protein, ... | Authors: | Pereira, P.J.B, Empadinhas, N, Costa, M.S, Macedo-Ribeiro, S. | Deposit date: | 2008-08-05 | Release date: | 2008-12-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis Plos One, 3, 2008
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3ETM
| Crystal structure of the mimivirus NDK +KPN-N62L-R107G triple mutant complexed with CDP | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside diphosphate kinase | Authors: | Jeudy, S, Lartigue, A, Claverie, J.M, Abergel, C. | Deposit date: | 2008-10-08 | Release date: | 2009-08-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Dissecting the unique nucleotide specificity of mimivirus nucleoside diphosphate kinase. J.Virol., 83, 2009
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3EGY
| Crystal Structure of Human Thymidyalte Synthase A191K with Loop 181-197 stabilized in the inactive conformation | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase | Authors: | Lovelace, L.L, Gibson, L.M, Johnson, S.R, Berger, S.H, Lebioda, L. | Deposit date: | 2008-09-11 | Release date: | 2009-08-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation. Protein Sci., 18, 2009
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6X4B
| Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-5-fluoro-8-methyl-2-naphthonitrile (JLJ655), a Non-nucleoside Inhibitor | Descriptor: | 7-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-5-fluoro-8-methylnaphthalene-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... | Authors: | Chan, A.H, Duong, V.N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S. | Deposit date: | 2020-05-22 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. Protein Sci., 29, 2020
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3EMF
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3EOH
| Refined group II intron structure | Descriptor: | 5'-R(*UP*UP*AP*UP*UP*A)-3', Group IIC intron, MAGNESIUM ION, ... | Authors: | Toor, N, Rajashankar, K, Keating, K.S, Pyle, A.M. | Deposit date: | 2008-09-26 | Release date: | 2008-10-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.125 Å) | Cite: | Structural basis for exon recognition by a group II intron. Nat.Struct.Mol.Biol., 15, 2008
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3ENA
| Crystal structure of the mimivirus NDK +Kpn-N62L-R107G triple mutant complexed with dGDP | Descriptor: | 2'-DEOXYGUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside diphosphate kinase | Authors: | Jeudy, S, Lartigue, A, Claverie, J.M, Abergel, C. | Deposit date: | 2008-09-25 | Release date: | 2009-08-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Dissecting the unique nucleotide specificity of mimivirus nucleoside diphosphate kinase. J.Virol., 83, 2009
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3EVO
| Crystal structure of the Mimivirus NDK +Kpn mutant complexed with dTDP | Descriptor: | MAGNESIUM ION, Nucleoside diphosphate kinase, THYMIDINE-5'-DIPHOSPHATE | Authors: | Jeudy, S, Lartigue, A, Claverie, J.M, Abergel, C. | Deposit date: | 2008-10-13 | Release date: | 2009-08-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Dissecting the unique nucleotide specificity of mimivirus nucleoside diphosphate kinase. J.Virol., 83, 2009
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3EUP
| The crystal structure of the transcriptional regulator, TetR family from Cytophaga hutchinsonii | Descriptor: | SULFATE ION, Transcriptional regulator, TetR family | Authors: | Zhang, R, Bigelow, L, Abdullah, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-10-10 | Release date: | 2008-11-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | The crystal structure of the transcriptional regulator, TetR family from Cytophaga hutchinsonii To be Published
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1Z5S
| Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2 | Descriptor: | Ran GTPase-activating protein 1, Ran-binding protein 2, Ubiquitin-conjugating enzyme E2 I, ... | Authors: | Reverter, D, Lima, C.D. | Deposit date: | 2005-03-19 | Release date: | 2005-06-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature, 435, 2005
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