8EMI
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![BU of 8emi by Molmil](/molmil-images/mine/8emi) | |
6O4Y
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![BU of 6o4y by Molmil](/molmil-images/mine/6o4y) | Structure of HLA-A2:01 with peptide MM91 | Descriptor: | Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ... | Authors: | Ying, G, Bitra, A, Zajonc, D.M. | Deposit date: | 2019-03-01 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Anin silico-in vitroPipeline Identifying an HLA-A*02:01+KRAS G12V+Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients. Front Immunol, 10, 2019
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7KGS
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![BU of 7kgs by Molmil](/molmil-images/mine/7kgs) | Crystal Structure of HLA-A*0201 in complex with SARS-CoV-2 N138-146 | Descriptor: | ACETATE ION, Beta-2-microglobulin, CADMIUM ION, ... | Authors: | Szeto, C, Chatzileontiadou, D.S.M, Riboldi-Tunnicliffe, A, Gras, S. | Deposit date: | 2020-10-18 | Release date: | 2021-01-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | The presentation of SARS-CoV-2 peptides by the common HLA-A*02:01 molecule. Iscience, 24, 2021
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6BXQ
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![BU of 6bxq by Molmil](/molmil-images/mine/6bxq) | Crystal Structure of HLA-B*57:01 with an HIV peptide RKV | Descriptor: | Beta-2-microglobulin, HIV peptide RKV, MHC class I antigen | Authors: | Gras, S, Rossjohn, J. | Deposit date: | 2017-12-18 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics. Proteomics, 18, 2018
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5WMR
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![BU of 5wmr by Molmil](/molmil-images/mine/5wmr) | Crystal Structure of HLA-B8 in complex with QIK, a CMV peptide | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... | Authors: | Gras, S, Rossjohn, J. | Deposit date: | 2017-07-31 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses. J. Immunol., 200, 2018
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7CIQ
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![BU of 7ciq by Molmil](/molmil-images/mine/7ciq) | Phosphorylation modification of MHC I polypeptide | Descriptor: | ARG-ARG-PHE-SER-ARG-SER-PRO-ILE-ARG-ARG, Beta-2-microglobulin, MHC class I antigen | Authors: | Sun, M.W, Feng, L, Qi, J.X, Liu, W.J, Gao, G.F. | Deposit date: | 2020-07-08 | Release date: | 2022-03-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Phosphosite-dependent presentation of dual phosphorylated peptides by MHC class I molecules. Iscience, 25, 2022
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4U1H
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![BU of 4u1h by Molmil](/molmil-images/mine/4u1h) | HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GAG protein, ... | Authors: | Rizkallah, P.J, Cole, D.K, Fuller, A, Sewell, A.K. | Deposit date: | 2014-07-15 | Release date: | 2015-04-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology, 12, 2015
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6P27
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![BU of 6p27 by Molmil](/molmil-images/mine/6p27) | Structure of a nested set of N-terminally extended MHC I-peptides provides novel insights into antigen processing and presentation | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... | Authors: | Li, L, Batliwala, M, Bouvier, M. | Deposit date: | 2019-05-21 | Release date: | 2019-10-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.593 Å) | Cite: | ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation. J.Biol.Chem., 294, 2019
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6P23
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![BU of 6p23 by Molmil](/molmil-images/mine/6p23) | Structure of a nested set of N-terminally extended MHC I-peptides provide novel insights into antigen processing presentation | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... | Authors: | Li, L, Batliwala, M, Bouvier, M. | Deposit date: | 2019-05-20 | Release date: | 2019-10-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.595 Å) | Cite: | ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation. J.Biol.Chem., 294, 2019
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1ZHK
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![BU of 1zhk by Molmil](/molmil-images/mine/1zhk) | Crystal structure of HLA-B*3501 presenting 13-mer EBV antigen LPEPLPQGQLTAY | Descriptor: | Beta-2-microglobulin, EBV-peptide LPEPLPQGQLTAY, HLA class I histocompatibility antigen, ... | Authors: | Tynan, F.E, Borg, N.A, Miles, J.J, Beddoe, T, El-Hassen, D, Silins, S.L, van Zuylen, W.J, Purcell, A.W, Kjer-Nielsen, L, McCluskey, J, Burrows, S.R, Rossjohn, J. | Deposit date: | 2005-04-26 | Release date: | 2005-05-17 | Last modified: | 2014-04-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The high resolution structures of highly bulged viral epitopes bound to the major histocompatability class I: Implications for T-cell receptor engagement and T-cell immunodominance J.Biol.Chem., 280, 2005
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7R7V
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![BU of 7r7v by Molmil](/molmil-images/mine/7r7v) | Crystal structure of HLA-B*5301 complex with an HIV-1 Gag-derived epitope QW9 | Descriptor: | Beta-2-microglobulin, GLN-ALA-SER-GLN-GLU-VAL-LYS-ASN-TRP, GLYCEROL, ... | Authors: | Li, X.L, Tan, K.M, Walker, B.D, Wang, J.H. | Deposit date: | 2021-06-25 | Release date: | 2022-06-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide. Nat Commun, 14, 2023
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6TDQ
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![BU of 6tdq by Molmil](/molmil-images/mine/6tdq) | Crystal structure of the disulfide engineered HLA-A0201 molecule in complex with one GM dipeptide in the A pocket and one GM dipeptide in the F pocket. | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ... | Authors: | Anjanappa, R, Garcia Alai, M, Springer, S, Meijers, R. | Deposit date: | 2019-11-10 | Release date: | 2020-03-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection. Nat Commun, 11, 2020
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6J29
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![BU of 6j29 by Molmil](/molmil-images/mine/6j29) | The structure of HLA-A*3003/MTB | Descriptor: | Beta-2-microglobulin, HLA-A*3003, MTB | Authors: | Zhu, S.Y, Liu, K.F, Chai, Y, Ding, C.M, Lv, J.X, Gao, F.G, Lou, Y.L, Liu, W.J. | Deposit date: | 2018-12-31 | Release date: | 2019-09-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides. Front Immunol, 10, 2019
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8GLG
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![BU of 8glg by Molmil](/molmil-images/mine/8glg) | Crystal Structure of Human CD1b in Complex with Phosphatidylethanolamine C34:1 | Descriptor: | (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1,2-ETHANEDIOL, Beta-2-microglobulin, ... | Authors: | Shahine, A. | Deposit date: | 2023-03-22 | Release date: | 2023-09-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms. Cell, 186, 2023
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7MJ7
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![BU of 7mj7 by Molmil](/molmil-images/mine/7mj7) | HLA-A*02:01 bound to Neuroblastoma Derived IGFBPL1 peptide | Descriptor: | Beta-2-microglobulin, GLYCEROL, Insulin-like growth factor-binding protein-like 1 peptide, ... | Authors: | Toor, J.S, Tripathi, S.M, Truong, H.V, Yarmarkovich, M, Maris, J.M, Sgourakis, N.G. | Deposit date: | 2021-04-19 | Release date: | 2021-08-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs. Nature, 599, 2021
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3GSO
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![BU of 3gso by Molmil](/molmil-images/mine/3gso) | Crystal structure of the binary complex between HLA-A2 and HCMV NLV peptide | Descriptor: | Beta-2-microglobulin, HCMV pp65 fragment 495-503 (NLVPMVATV), HLA class I histocompatibility antigen, ... | Authors: | Gras, S, Saulquin, X, Reiser, J.-B, Debeaupuis, E, Echasserieau, K, Kissenpfennig, A, Legoux, F, Chouquet, A, Le Gorrec, M, Machillot, P, Neveu, B, Thielens, N, Malissen, B, Bonneville, M, Housset, D. | Deposit date: | 2009-03-27 | Release date: | 2009-08-04 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope. J.Immunol., 183, 2009
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4G9D
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![BU of 4g9d by Molmil](/molmil-images/mine/4g9d) | Crystal Structure of HLA B2705-KK10 | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Gras, S, Wilmann, P.G, Rossjohn, J. | Deposit date: | 2012-07-23 | Release date: | 2013-03-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8(+) T Cells. Immunity, 38, 2013
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3VRI
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![BU of 3vri by Molmil](/molmil-images/mine/3vri) | HLA-B*57:01-RVAQLENVYI in complex with abacavir | Descriptor: | 10-mer peptide, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Vivian, J.P, Illing, P.T, McCluskey, J, Rossjohn, J. | Deposit date: | 2012-04-11 | Release date: | 2012-05-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Immune self-reactivity triggered by drug-modified HLA-peptide repertoire Nature, 486, 2012
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7S8E
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![BU of 7s8e by Molmil](/molmil-images/mine/7s8e) | STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH MLL(747-755) PHOSPHOPEPTIDE AND BOUND GLYCEROL | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Patskovsky, Y, Nyovanie, S, Patskovska, L, Natarajan, A, Joshi, B, Morin, B, Brittsan, C, Huber, O, Gordon, S, Michelet, X, Schmitzberger, F, Stein, R, Findeis, M, Hurwitz, A, Van Dijk, M, Buell, J, Underwood, D, Krogsgaard, M. | Deposit date: | 2021-09-17 | Release date: | 2022-11-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Molecular mechanism of phosphopeptide neoantigen immunogenicity. Nat Commun, 14, 2023
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2HN7
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![BU of 2hn7 by Molmil](/molmil-images/mine/2hn7) | HLA-A*1101 in complex with HBV peptide homologue | Descriptor: | Beta-2-microglobulin, DNA polymerase PEPTIDE HOMOLOGUE, HLA class I histocompatibility antigen, ... | Authors: | Blicher, T. | Deposit date: | 2006-07-12 | Release date: | 2006-11-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue. Acta Crystallogr.,Sect.F, 62, 2006
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6V2Q
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![BU of 6v2q by Molmil](/molmil-images/mine/6v2q) | HLA-B*57:03 presenting the peptide LSSPVTKSF | Descriptor: | ACETATE ION, Beta-2-microglobulin, HLA-B alpha chain (B*5703GB), ... | Authors: | Maclachlan, B, Rossjohn, J, Vivian, J.P. | Deposit date: | 2019-11-25 | Release date: | 2020-05-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function. Proc.Natl.Acad.Sci.USA, 117, 2020
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6K7T
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![BU of 6k7t by Molmil](/molmil-images/mine/6k7t) | Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV1--human beta-2 microglobulin | Descriptor: | Beta-2-microglobulin, HeV1, MHC class I antigen | Authors: | Lu, D, Liu, K.F, Zhang, D, Yue, C, Lu, Q, Cheng, H, Chai, Y, Qi, J.X, Gao, F.G, Liu, W.J. | Deposit date: | 2019-06-08 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats. Plos Biol., 17, 2019
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2V2W
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![BU of 2v2w by Molmil](/molmil-images/mine/2v2w) | T CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENT | Descriptor: | BETA-2 MICROGLOBULIN, HIV P17, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ... | Authors: | Lee, J.K, Stewart-Jones, G, Dong, T, Harlos, K, Di Gleria, K, Dorrell, L, Douek, D.C, Van Der Merwe, P.A, Jones, E.Y, Mcmichael, A.J. | Deposit date: | 2007-06-07 | Release date: | 2007-11-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | T Cell Cross-Reactivity and Conformational Changes During Tcr Engagement. J.Exp.Med., 200, 2004
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2V2X
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![BU of 2v2x by Molmil](/molmil-images/mine/2v2x) | T cell cross-reactivity and conformational changes during TCR engagement. | Descriptor: | BETA-2 MICROGLOBULIN, HIV P17, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ... | Authors: | Lee, J.K, Stewart-Jones, G, Dong, T, harlos, K, Di Gleria, K, Dorrell, L, Douek, D.C, van der Merwe, P.A, Jones, E.Y, McMichael, A.J. | Deposit date: | 2007-06-07 | Release date: | 2007-11-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | T Cell Cross-Reactivity and Conformational Changes During Tcr Engagement. J.Exp.Med., 200, 2004
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5DEF
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![BU of 5def by Molmil](/molmil-images/mine/5def) | Crystal structure of B*27:04 complex bound to the pVIPR peptide | Descriptor: | Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ... | Authors: | Loll, B, Fabian, H, Huser, H, Hee, C.S, Uchanska-Ziegler, B, Ziegler, A. | Deposit date: | 2015-08-25 | Release date: | 2015-11-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Increased Conformational Flexibility of HLA-B*27 Subtypes Associated With Ankylosing Spondylitis. Arthritis Rheumatol, 68, 2016
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