3H4L
 
 | | Crystal Structure of N terminal domain of a DNA repair protein | | Descriptor: | DNA mismatch repair protein PMS1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Arana, M.E, Holmes, S.F, Fortune, J.M, Moon, A.F, Pedersen, L.C, Kunkel, T.A. | | Deposit date: | 2009-04-20 | | Release date: | 2010-03-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Functional residues on the surface of the N-terminal domain of yeast Pms1.
Dna Repair, 9, 2010
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7P8V
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4P7A
 | | Crystal Structure of human MLH1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Mlh1, MAGNESIUM ION, ... | | Authors: | Tempel, W, Lam, R, Zeng, H, Walker, J.R, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2014-03-26 | | Release date: | 2014-04-09 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
Acta Crystallogr.,Sect.F, 71, 2015
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5X9Y
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6LZJ
 | | Aquifex aeolicus MutL ATPase domain complexed with AMPPCP | | Descriptor: | DNA mismatch repair protein MutL, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | | Authors: | Fukui, K, Izuhara, K, Yano, T. | | Deposit date: | 2020-02-19 | | Release date: | 2020-07-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.72835565 Å) | | Cite: | A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL.
J.Biol.Chem., 295, 2020
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6MFQ
 | | Crystal structure of a PMS2 variant | | Descriptor: | Mismatch repair endonuclease PMS2 | | Authors: | D'Arcy, B.M, Prakash, A. | | Deposit date: | 2018-09-11 | | Release date: | 2019-02-06 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Biochemical and structural characterization of two variants of uncertain significance in the PMS2 gene.
Hum. Mutat., 40, 2019
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6LZI
 | | Aquifex aeolicus MutL ATPase domain complexed with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA mismatch repair protein MutL, ... | | Authors: | Fukui, K, Izuhara, K, Yano, T. | | Deposit date: | 2020-02-19 | | Release date: | 2020-07-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.69105685 Å) | | Cite: | A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL.
J.Biol.Chem., 295, 2020
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6LZK
 | | Aquifex aeolicus MutL ATPase domain with K252N mutation | | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA mismatch repair protein MutL, SODIUM ION | | Authors: | Fukui, K, Izuhara, K, Yano, T. | | Deposit date: | 2020-02-19 | | Release date: | 2020-07-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.15949631 Å) | | Cite: | A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL.
J.Biol.Chem., 295, 2020
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7RCB
 | | Crystal Structure of a PMS2 VUS | | Descriptor: | Mismatch repair endonuclease PMS2 | | Authors: | D'Arcy, B.M, Prakash, A. | | Deposit date: | 2021-07-07 | | Release date: | 2022-03-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
Mol Genet Genomic Med, 10, 2022
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7RCI
 | | Crystal Structure of a PMS2 VUS with Substrate | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mismatch repair endonuclease PMS2 | | Authors: | D'Arcy, B.M, Prakash, A. | | Deposit date: | 2021-07-07 | | Release date: | 2022-03-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
Mol Genet Genomic Med, 10, 2022
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7RCK
 | | Crystal Structure of PMS2 with Substrate | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mismatch repair endonuclease PMS2 | | Authors: | D'Arcy, B.M, Prakash, A. | | Deposit date: | 2021-07-07 | | Release date: | 2022-03-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
Mol Genet Genomic Med, 10, 2022
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1EA6
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1NHJ
 | | Crystal structure of N-terminal 40KD MutL/A100P mutant protein complex with ADPnP and one sodium | | Descriptor: | DNA mismatch repair protein mutL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Hu, X, Machius, M, Yang, W. | | Deposit date: | 2002-12-19 | | Release date: | 2003-06-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
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1NHI
 | | Crystal structure of N-terminal 40KD MutL (LN40) complex with ADPnP and one potassium | | Descriptor: | 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ... | | Authors: | Hu, X, Machius, M, Yang, W. | | Deposit date: | 2002-12-19 | | Release date: | 2003-06-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
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1B62
 | | MUTL COMPLEXED WITH ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (MUTL) | | Authors: | Wei, Y. | | Deposit date: | 1999-01-11 | | Release date: | 1999-04-28 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair.
Cell(Cambridge,Mass.), 97, 1999
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1NHH
 | | Crystal structure of N-terminal 40KD MutL protein (LN40) complex with ADPnP and one Rubidium | | Descriptor: | 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ... | | Authors: | Hu, X, Machius, M, Yang, W. | | Deposit date: | 2002-12-19 | | Release date: | 2003-06-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
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1H7U
 | | hPMS2-ATPgS | | Descriptor: | MAGNESIUM ION, MISMATCH REPAIR ENDONUCLEASE PMS2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Guarne, A, Junop, M.S, Yang, W. | | Deposit date: | 2001-07-10 | | Release date: | 2001-11-27 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure and Function of the N-Terminal 40 kDa Fragment of Human Pms2: A Monomeric Ghl ATPase
Embo J., 20, 2001
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1B63
 | | MUTL COMPLEXED WITH ADPNP | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, MUTL, ... | | Authors: | Yang, W. | | Deposit date: | 1999-01-20 | | Release date: | 1999-06-08 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair.
Cell(Cambridge,Mass.), 97, 1999
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1H7S
 | | N-terminal 40kDa fragment of human PMS2 | | Descriptor: | PMS1 PROTEIN HOMOLOG 2 | | Authors: | Guarne, A, Junop, M.S, Yang, W. | | Deposit date: | 2001-07-10 | | Release date: | 2001-11-27 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure and Function of the N-Terminal 40 kDa Fragment of Human Pms2: A Monomeric Ghl ATPase
Embo J., 20, 2001
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1BKN
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7AIB
 | | MutS-MutL in clamp state | | Descriptor: | DNA (30-MER), DNA mismatch repair protein MutL, DNA mismatch repair protein MutS, ... | | Authors: | Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H. | | Deposit date: | 2020-09-26 | | Release date: | 2021-03-31 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
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7AIC
 | | MutS-MutL in clamp state (kinked clamp domain) | | Descriptor: | DNA (30-MER), DNA mismatch repair protein MutL, DNA mismatch repair protein MutS, ... | | Authors: | Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H. | | Deposit date: | 2020-09-26 | | Release date: | 2021-03-31 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
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5AKC
 | | MutS in complex with the N-terminal domain of MutL - crystal form 2 | | Descriptor: | DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K. | | Deposit date: | 2015-03-03 | | Release date: | 2015-07-22 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (6.6 Å) | | Cite: | MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Elife, 4, 2015
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5AKD
 | | MutS in complex with the N-terminal domain of MutL - crystal form 3 | | Descriptor: | DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K. | | Deposit date: | 2015-03-03 | | Release date: | 2015-07-22 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (7.6 Å) | | Cite: | MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Elife, 4, 2015
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5AKB
 | | MutS in complex with the N-terminal domain of MutL - crystal form 1 | | Descriptor: | DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K. | | Deposit date: | 2015-03-03 | | Release date: | 2015-07-22 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (4.71 Å) | | Cite: | MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Elife, 4, 2015
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