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PDB: 265 results

1XC9
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BU of 1xc9 by Molmil
Structure of a high-fidelity polymerase bound to a benzo[a]pyrene adduct that blocks replication
Descriptor: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, DNA polymerase I, DNA primer strand, ...
Authors:Hsu, G.W, Huang, X, Luneva, N.P, Geacintov, N.E, Beese, L.S.
Deposit date:2004-09-01
Release date:2004-12-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a High Fidelity DNA Polymerase Bound to a Benzo[a]pyrene Adduct That Blocks Replication
J.Biol.Chem., 280, 2005
1XWL
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BU of 1xwl by Molmil
BACILLUS STEAROTHERMOPHILUS (NEWLY IDENTIFIED STRAIN AS YET UNNAMED) DNA POLYMERASE FRAGMENT
Descriptor: DNA POLYMERASE I, SULFATE ION
Authors:Kiefer, J.R, Mao, C, Beese, L.S.
Deposit date:1998-07-22
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution.
Structure, 5, 1997
1U47
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BU of 1u47 by Molmil
cytosine-8-Oxoguanine base pair at the polymerase active site
Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ...
Authors:Hsu, G.W, Ober, M, Carell, T, Beese, L.S.
Deposit date:2004-07-23
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase.
Nature, 431, 2004
2HHT
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BU of 2hht by Molmil
C:O6-methyl-guanine pair in the polymerase-2 basepair position
Descriptor: 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*TP*CP*G)-3', 5'-D(*GP*TP*AP*CP*(6OG)P*AP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', DNA polymerase I, ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HHW
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BU of 2hhw by Molmil
ddTTP:O6-methyl-guanine pair in the polymerase active site, in the closed conformation
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DDG))-3', ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HHS
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BU of 2hhs by Molmil
O6-methyl:C pair in the polymerase-10 basepair position
Descriptor: 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*GP*CP*AP*TP*GP*A)-3', DNA polymerase I, ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HHQ
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BU of 2hhq by Molmil
O6-methyl-guanine:T pair in the polymerase-10 basepair position
Descriptor: 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*GP*CP*CP*TP*GP*AP*CP*TP*CP*GP*TP*AP*TP*GP*A)-3', DNA polymerase I, ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HHU
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BU of 2hhu by Molmil
C:O6-methyl-guanine in the polymerase postinsertion site (-1 basepair position)
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*CP*C)-3', 5'-D(*GP*TP*AP*CP*(6OG)P*GP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HHV
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BU of 2hhv by Molmil
T:O6-methyl-guanine in the polymerase-2 basepair position
Descriptor: 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*TP*TP*G)-3', 5'-D(*GP*TP*AP*CP*(6OG)P*AP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', DNA Polymerase I, ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HHX
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BU of 2hhx by Molmil
O6-methyl-guanine in the polymerase template preinsertion site
Descriptor: 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*G)-3', DNA Polymerase I, ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HVH
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BU of 2hvh by Molmil
ddCTP:O6MeG pair in the polymerase active site (0 position)
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*CP*A*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DDG))-3', ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-07-28
Release date:2006-12-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.492 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HVI
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BU of 2hvi by Molmil
ddCTP:G pair in the polymerase active site (0 position)
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*C*AP*TP*GP*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DDG))-3', ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-07-28
Release date:2006-12-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HW3
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BU of 2hw3 by Molmil
T:O6-methyl-guanine pair in the polymerase postinsertion site (-1 basepair position)
Descriptor: 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*TP*T)-3', 5'-D(*GP*TP*A*CP*(6OG)P*AP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', DNA Polymerase I, ...
Authors:Warren, J.J, Forsberg, L.J, Beese, L.S.
Deposit date:2006-07-31
Release date:2006-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
6DSW
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BU of 6dsw by Molmil
Bst DNA polymerase I pre-chemistry (n) structure
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*G)-3'), DNA (5'-D(P*AP*CP*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), ...
Authors:Chim, N, Jackson, L.N, Chaput, J.C.
Deposit date:2018-06-14
Release date:2018-10-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.589 Å)
Cite:Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.
Elife, 7, 2018
6DSY
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BU of 6dsy by Molmil
Bst DNA polymerase I post-chemistry (n+1) structure
Descriptor: DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ...
Authors:Chim, N, Jackson, L.N, Chaput, J.C.
Deposit date:2018-06-14
Release date:2018-10-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.
Elife, 7, 2018
6DSU
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BU of 6dsu by Molmil
Bst DNA polymerase I pre-insertion complex structure
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), ...
Authors:Chim, N, Jackson, L.N, Chaput, J.C.
Deposit date:2018-06-14
Release date:2018-10-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.
Elife, 7, 2018
6DSX
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BU of 6dsx by Molmil
Bst DNA polymerase I post-chemistry (n+1 with dATP soak) structure
Descriptor: DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*TP*A)-3'), DNA (5'-D(*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ...
Authors:Chim, N, Jackson, L.N, Chaput, J.C.
Deposit date:2018-06-14
Release date:2018-10-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.
Elife, 7, 2018
6DSV
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BU of 6dsv by Molmil
Bst DNA polymerase I post-chemistry (n+2) structure
Descriptor: DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*TP*A)-3'), DNA (5'-D(P*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ...
Authors:Chim, N, Jackson, L.N, Chaput, J.C.
Deposit date:2018-06-14
Release date:2018-10-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.
Elife, 7, 2018
8SCJ
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BU of 8scj by Molmil
Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 2h
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
Authors:Fang, Z, Lelyveld, V.S, Szostak, J.W.
Deposit date:2023-04-05
Release date:2023-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
8SCI
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BU of 8sci by Molmil
Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 1h
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
Authors:Fang, Z, Lelyveld, V.S, Szostak, J.W.
Deposit date:2023-04-05
Release date:2023-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
8SCL
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BU of 8scl by Molmil
Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 6h
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
Authors:Fang, Z, Lelyveld, V.S, Szostak, J.W.
Deposit date:2023-04-05
Release date:2023-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
8SCG
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BU of 8scg by Molmil
Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 0h (Ground State)
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 3'-Amino DNA Primer, CALCIUM ION, ...
Authors:Fang, Z, Lelyveld, V.S, Szostak, J.W.
Deposit date:2023-04-05
Release date:2023-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
8SCM
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BU of 8scm by Molmil
Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 8h
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
Authors:Fang, Z, Lelyveld, V.S, Szostak, J.W.
Deposit date:2023-04-05
Release date:2023-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
8SCK
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BU of 8sck by Molmil
Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 4h
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
Authors:Fang, Z, Lelyveld, V.S, Szostak, J.W.
Deposit date:2023-04-05
Release date:2023-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023
8SCO
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BU of 8sco by Molmil
Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 0h (Ground State)
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 3'-Amino DNA primer, CALCIUM ION, ...
Authors:Fang, Z, Lelyveld, V.S, Szostak, J.W.
Deposit date:2023-04-05
Release date:2023-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science, 382, 2023

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