7XVM
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![BU of 7xvm by Molmil](/molmil-images/mine/7xvm) | Crystal Structure of Nucleosome-H5 Linker Histone Assembly (sticky-169a DNA fragment) | Descriptor: | CALCIUM ION, CHLORIDE ION, DNA (169-MER), ... | Authors: | Adhireksan, Z, Qiuye, B, Lee, P.L, Sharma, D, Padavattan, S, Davey, C.A. | Deposit date: | 2022-05-24 | Release date: | 2023-05-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Crystal Structure of Nucleosome-H1.0 Linker Histone Assembly (sticky-169a DNA fragment) To Be Published
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8EVH
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![BU of 8evh by Molmil](/molmil-images/mine/8evh) | CX3CR1 nucleosome and wild type PU.1 complex | Descriptor: | DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | Authors: | Lian, T, Guan, R, Bai, Y. | Deposit date: | 2022-10-20 | Release date: | 2023-11-01 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
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7K61
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![BU of 7k61 by Molmil](/molmil-images/mine/7k61) | Cryo-EM structure of 197bp nucleosome aided by scFv | Descriptor: | DNA (197-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Zhou, B.-R, Bai, Y. | Deposit date: | 2020-09-17 | Release date: | 2020-11-25 | Last modified: | 2021-01-20 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms. Mol.Cell, 81, 2021
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5GXQ
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![BU of 5gxq by Molmil](/molmil-images/mine/5gxq) | The crystal structure of the nucleosome containing H3.6 | Descriptor: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Taguchi, H, Xie, Y, Horikoshi, N, Kurumizaka, H. | Deposit date: | 2016-09-19 | Release date: | 2017-04-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 Biochemistry, 56, 2017
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6K1J
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![BU of 6k1j by Molmil](/molmil-images/mine/6k1j) | Human nucleosome core particle with H2A.X variant | Descriptor: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | Authors: | Sharma, D, De Falco, L, Davey, C.A. | Deposit date: | 2019-05-10 | Release date: | 2020-01-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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7COW
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![BU of 7cow by Molmil](/molmil-images/mine/7cow) | 353 bp di-nucleosome harboring cohesive DNA termini with linker histone H1.0 | Descriptor: | CALCIUM ION, CHLORIDE ION, DNA (353-MER), ... | Authors: | Adhireksan, Z, Sharma, D, Lee, P.L, Davey, C.A. | Deposit date: | 2020-08-05 | Release date: | 2021-08-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Engineering nucleosomes for generating diverse chromatin assemblies. Nucleic Acids Res., 49, 2021
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5XF4
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![BU of 5xf4 by Molmil](/molmil-images/mine/5xf4) | Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (S,S-configuration) | Descriptor: | (1S,2S)-1,2-diphenylethane-1,2-diamine, DNA (145-MER), Histone H2A type 1-B/E, ... | Authors: | Ma, Z, Adhireksan, Z, Murray, B.S, Dyson, P.J, Davey, C.A. | Deposit date: | 2017-04-07 | Release date: | 2017-10-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation Nat Commun, 8, 2017
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3AZM
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![BU of 3azm by Molmil](/molmil-images/mine/3azm) | Crystal Structure of Human Nucleosome Core Particle Containing H4K79Q mutation | Descriptor: | 146-MER DNA, CHLORIDE ION, Histone H2A type 1-B/E, ... | Authors: | Iwasaki, W, Tachiwana, H, Kawaguchi, K, Shibata, T, Kagawa, W, Kurumizaka, H. | Deposit date: | 2011-05-25 | Release date: | 2011-09-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Comprehensive Structural Analysis of Mutant Nucleosomes Containing Lysine to Glutamine (KQ) Substitutions in the H3 and H4 Histone-Fold Domains Biochemistry, 50, 2011
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8VFY
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![BU of 8vfy by Molmil](/molmil-images/mine/8vfy) | |
3AZJ
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![BU of 3azj by Molmil](/molmil-images/mine/3azj) | Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation | Descriptor: | 146-MER DNA, CHLORIDE ION, Histone H2A type 1-B/E, ... | Authors: | Iwasaki, W, Tachiwana, H, Kawaguchi, K, Shibata, T, Kagawa, W, Kurumizaka, H. | Deposit date: | 2011-05-25 | Release date: | 2011-09-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Comprehensive Structural Analysis of Mutant Nucleosomes Containing Lysine to Glutamine (KQ) Substitutions in the H3 and H4 Histone-Fold Domains Biochemistry, 50, 2011
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8XBW
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![BU of 8xbw by Molmil](/molmil-images/mine/8xbw) | The cryo-EM structure of the RAD51 N-terminal lobe domain bound to the histone H4 tail of the nucleosome | Descriptor: | DNA (5'-D(P*AP*CP*CP*GP*CP*TP*TP*AP*AP*AP*CP*GP*CP*AP*CP*GP*TP*A)-3'), DNA (5'-D(P*TP*AP*CP*GP*TP*GP*CP*GP*TP*TP*TP*AP*AP*GP*CP*GP*GP*T)-3'), DNA repair protein RAD51 homolog 1, ... | Authors: | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | Deposit date: | 2023-12-07 | Release date: | 2024-03-27 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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3AYW
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![BU of 3ayw by Molmil](/molmil-images/mine/3ayw) | Crystal Structure of Human Nucleosome Core Particle Containing H3K56Q mutation | Descriptor: | 146-MER DNA, CHLORIDE ION, Histone H2A type 1-B/E, ... | Authors: | Iwasaki, W, Tachiwana, H, Kawaguchi, K, Shibata, T, Kagawa, W, Kurumizaka, H. | Deposit date: | 2011-05-19 | Release date: | 2011-09-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Comprehensive Structural Analysis of Mutant Nucleosomes Containing Lysine to Glutamine (KQ) Substitutions in the H3 and H4 Histone-Fold Domains Biochemistry, 50, 2011
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5ZGC
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![BU of 5zgc by Molmil](/molmil-images/mine/5zgc) | |
5CPI
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![BU of 5cpi by Molmil](/molmil-images/mine/5cpi) | Nucleosome containing unmethylated Sat2R DNA | Descriptor: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Osakabe, A, Arimura, Y, Adachi, F, Maehara, K, Ohkawa, Y, Kurumizaka, H. | Deposit date: | 2015-07-21 | Release date: | 2015-10-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.902 Å) | Cite: | Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA. Open Biology, 5, 2015
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5BO0
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![BU of 5bo0 by Molmil](/molmil-images/mine/5bo0) | |
5GT3
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![BU of 5gt3 by Molmil](/molmil-images/mine/5gt3) | Crystal structure of nucleosome particle in the presence of human testis-specific histone variant, hTh2b | Descriptor: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-D, ... | Authors: | Kumarevel, T, Sivaraman, P. | Deposit date: | 2016-08-18 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b Biophys. Chem., 221, 2017
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7LYA
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![BU of 7lya by Molmil](/molmil-images/mine/7lya) | Cryo-EM structure of the human nucleosome core particle with linked histone proteins H2A and H2B | Descriptor: | DNA (146-MER), DNA (147-MER), Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. | Deposit date: | 2021-03-06 | Release date: | 2021-07-28 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
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3X1V
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![BU of 3x1v by Molmil](/molmil-images/mine/3x1v) | |
5B33
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![BU of 5b33 by Molmil](/molmil-images/mine/5b33) | The crystal structure of the H2AZ nucleosome with H3.3. | Descriptor: | DNA (146-MER), Histone H2A.Z, Histone H2B type 1-J, ... | Authors: | Horikoshi, N, Taguchi, H, Arimura, Y, Kurumizaka, H. | Deposit date: | 2016-02-08 | Release date: | 2016-08-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.925 Å) | Cite: | Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A. Open Biology, 6, 2016
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7K5X
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![BU of 7k5x by Molmil](/molmil-images/mine/7k5x) | |
7LYC
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![BU of 7lyc by Molmil](/molmil-images/mine/7lyc) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777) | Descriptor: | BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. | Deposit date: | 2021-03-06 | Release date: | 2021-06-16 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
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6X59
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![BU of 6x59 by Molmil](/molmil-images/mine/6x59) | The mouse cGAS catalytic domain binding to human assembled nucleosome | Descriptor: | Cyclic GMP-AMP synthase, DNA, Histone H2A type 1, ... | Authors: | Pengbiao, X, Pingwei, L, Baoyu, Z. | Deposit date: | 2020-05-25 | Release date: | 2020-09-16 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature, 587, 2020
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4Z2M
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![BU of 4z2m by Molmil](/molmil-images/mine/4z2m) | Crystal structure of human SPT16 Mid-AID/H3-H4 tetramer FACT Histone complex | Descriptor: | FACT complex subunit SPT16, Histone H3.1, Histone H4 | Authors: | Tsunaka, Y, Fujiwara, Y, Oyama, T, Hirose, S, Morikawa, K. | Deposit date: | 2015-03-30 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.981 Å) | Cite: | Integrated molecular mechanism directing nucleosome reorganization by human FACT. Genes Dev., 30, 2016
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8YV8
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![BU of 8yv8 by Molmil](/molmil-images/mine/8yv8) | Cryo-EM structure of CDCA7 bound to nucleosome including hemimethylated CpG site in Widom601 positioning sequence. | Descriptor: | Cell division cycle-associated protein 7, DNA (132-MER), Histone H2A type 1-B/E, ... | Authors: | Kikuchi, A, Shikimachi, R, Nishiyama, A, Funabiki, H, Arita, K. | Deposit date: | 2024-03-28 | Release date: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS To Be Published
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7D20
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![BU of 7d20 by Molmil](/molmil-images/mine/7d20) | Cryo-EM structure of SET8-CENP-A-nucleosome complex | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Ho, C.-H, Takizawa, Y, Kobayashi, W, Arimura, Y, Kurumizaka, H. | Deposit date: | 2020-09-15 | Release date: | 2021-02-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase. Life Sci Alliance, 4, 2021
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