PDB: 277 件ウェブページステータス検索Chemie searchBIRD

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8OO0	Chaetomium thermophilum Methionine Aminopeptidase 2 autoproteolysis product at the 80S ribosome 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S0, ... 著者 Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. 登録日 2023-04-04 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome. Nat Commun, 15, 2024
8GB3	Structure of the Mycobacterium tuberculosis Hsp70 protein DnaK bound to the nucleotide exchange factor GrpE 分子名称: Chaperone protein DnaK, Protein GrpE 著者 Xiao, X, Li, H. 登録日 2023-02-24 公開日 2024-01-31 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structure of the M. tuberculosis DnaK-GrpE complex reveals how key DnaK roles are controlled. Nat Commun, 15, 2024
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... 著者 Wang, W, Hendrickson, W.A. 登録日 2021-07-04 公開日 2023-07-05 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Conformational equilibria in allosteric control of Hsp70 chaperones. Mol.Cell, 81, 2021
8D1Y	Crystal structure of Plasmodium falciparum GRP78 in complex with Trans-Zeatin Riboside 分子名称: Chaperone DnaK, N-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]adenosine, SULFATE ION 著者 Mrozek, A, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D1P	Crystal structure of Plasmodium falciparum GRP78-NBD in complex with 7-Deaza-2'-C-methyladenosine 分子名称: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D24	Crystal structure of Plasmodium falciparum GRP78-NBD in complex with VER155008 分子名称: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D1W	Crystal structure of Plasmodium falciparum GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 分子名称: 8-{[(2-chlorophenyl)methyl]amino}adenosine, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W, Smil, D, Zepeda, C.A.V. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Targeting Plasmodium falciparum GRP78: nucleoside analogues as agents against the malaria chaperone Frontiers in Molecular Bioscience, 2022
8D20	Crystal structure of Plasmodium falciparum GRP78 in complex with 5'-Methylthioadenosine 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D1S	Crystal structure of Plasmodium falciparum GRP78 in complex with Toyocamycin 分子名称: 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D1Q	Crystal structure of Plasmodium falciparum GRP78-NBD in complex with 8-Aminoadenosine 分子名称: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D22	Crystal structure of Plasmodium falciparum GRP78-NBD in complex with Piclidenoson 分子名称: Chaperone DnaK, Piclidenoson, SULFATE ION 著者 Mrozek, A, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8GLV	96-nm repeat unit of doublet microtubules from Chlamydomonas reinhardtii flagella 分子名称: 28 kDa inner dynein arm light chain, axonemal, AAA+ ATPase domain-containing protein, ... 著者 Walton, T, Brown, A. 登録日 2023-03-23 公開日 2023-05-31 最終更新日 2023-06-28 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Axonemal structures reveal mechanoregulatory and disease mechanisms. Nature, 618, 2023
7Z3N	Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation 分子名称: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... 著者 Kisonaite, M, Wild, K, Sinning, I. 登録日 2022-03-02 公開日 2023-04-12 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural inventory of cotranslational protein folding by the eukaryotic RAC complex. Nat.Struct.Mol.Biol., 30, 2023
7Z3O	Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation 分子名称: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... 著者 Kisonaite, M, Wild, K, Sinning, I. 登録日 2022-03-02 公開日 2023-04-12 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural inventory of cotranslational protein folding by the eukaryotic RAC complex. Nat.Struct.Mol.Biol., 30, 2023
7PLK	Crystal structure bovine Hsc70(aa1-554)E213A/D214A in complex with nicotinic-acid-derivative 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-pyrrol-1-ylpyridine-3-carboxylic acid, GLYCEROL, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-08-31 公開日 2022-09-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.48781371 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7FGM	The complex crystals structure of the FAF1 UBL1_L-Hsp70 NBD with ADP and phosphate 分子名称: ADENOSINE-5'-DIPHOSPHATE, FAS-associated factor 1, Heat shock 70 kDa protein 1A, ... 著者 Kim, E.E, ParK, J.K, Shin, S.C. 登録日 2021-07-27 公開日 2022-07-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation J Mol Cell Biol, 14, 2022
5UMB	Crystal structure of ATPase domain of Malaria GRP78 with ADP bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ... 著者 Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H. 登録日 2017-01-26 公開日 2022-07-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Repurposing drugs to target the malaria parasite unfolding protein response. Sci Rep, 8, 2018
7X3K	Cryo-EM structure of RAC in the State C2 RNC-RAC complex 分子名称: Ribosome-associated complex subunit SSZ1, Zuotin 著者 Chen, Y, Gao, N. 登録日 2022-03-01 公開日 2022-06-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding. Nat Commun, 13, 2022
7F4Z	X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1B, ... 著者 Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M. 登録日 2021-06-21 公開日 2022-06-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
7F4X	Joint neutron and X-ray crystal structure of the nucleotide-binding domain of Hsp72 in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... 著者 Yokoyama, T, Ostermann, A, Schrader, T.E. 登録日 2021-06-21 公開日 2022-06-29 最終更新日 2024-04-03 実験手法 NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION 主引用文献 Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
7F50	X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with AMPPnP 分子名称: CHLORIDE ION, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... 著者 Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M. 登録日 2021-06-21 公開日 2022-06-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
7ODI	Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with methanesulfonamide 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Heat shock cognate 71 kDa protein, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-04-29 公開日 2022-06-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7ODD	Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with tricine 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Heat shock cognate 71 kDa protein, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-04-29 公開日 2022-06-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.984 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7ODB	Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with triazine-derivative 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 6-methyl-5-sulfanylidene-2H-1,2,4-triazin-3-one, GLYCEROL, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-04-29 公開日 2022-06-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.662 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7N6G	C1 of central pair 分子名称: CPC1, Calmodulin, DPY30, ... 著者 Han, L, Zhang, K. 登録日 2021-06-08 公開日 2022-05-18 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structure of an active central apparatus. Nat.Struct.Mol.Biol., 29, 2022

 

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