PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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3HSC	THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN 分子名称: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 7OKD PROTEIN, MAGNESIUM ION, ... 著者 Flaherty, K.M, Deluca-Flaherty, C.R, Mckay, D.B. 登録日 1995-03-24 公開日 1995-07-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature, 346, 1990
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... 著者 Wang, W, Hendrickson, W.A. 登録日 2021-07-04 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Visualization of Hsp70-catalyzed ATP Hydrolysis To Be Published
2KHO	NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate 分子名称: Heat shock protein 70 著者 Zuiderweg, E.R.P, Bertelsen, E.B. 登録日 2009-04-10 公開日 2009-05-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc.Natl.Acad.Sci.USA, 106, 2009
6NHK	Mortalin nucleotide binding domain in the ADP-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Page, R.C, Moseng, M.A, Nix, J.C. 登録日 2018-12-23 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.777 Å) 主引用文献 Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
6ZHI	Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide 分子名称: ASN-ARG-LEU-LEU-LEU-THR-GLY, Heat shock protein 70 著者 Schmidt, J, Vakonakis, I. 登録日 2020-06-23 公開日 2020-09-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structure of the PfHsp70-x SBD Acta Crystallographica Section F
5XI9	Solution structure for human HSP70 substrate binding domain 分子名称: Heat shock 70 kDa protein 1A 著者 Hoshikawa, M, Tochio, N, Tate, S. 登録日 2017-04-26 公開日 2018-05-16 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
5XIR	Solution structure for human HSP70 substrate binding domain L542Y mutant 分子名称: Heat shock 70 kDa protein 1A 著者 Hoshikawa, M, Tochio, N, Tate, S. 登録日 2017-04-27 公開日 2018-05-16 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
1U00	HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC 分子名称: Chaperone protein hscA, IscU recognition peptide 著者 Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E. 登録日 2004-07-12 公開日 2004-10-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC. J.Mol.Biol., 342, 2004
6P2U	Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate 分子名称: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Moseng, M.A, Page, R.C. 登録日 2019-05-22 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. Febs Lett., 593, 2019
1S3X	The crystal structure of the human Hsp70 ATPase domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70 kDa protein 1, ... 著者 Sriram, M, Osipiuk, J, Freeman, B, Morimoto, R.I, Joachimiak, A. 登録日 2004-01-14 公開日 2004-01-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain Structure, 5, 1997
6PMT	Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate 分子名称: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ... 著者 Moseng, M.A, Nix, J.C, Page, R.C. 登録日 2019-07-02 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate to be published
4JWC	Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(1-16) 分子名称: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION 著者 Zahn, M, Straeter, N. 登録日 2013-03-27 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7. Protein Pept.Lett., 21, 2014
4KBO	Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form 分子名称: SODIUM ION, Stress-70 protein, mitochondrial 著者 Amick, J, Page, R.C, Nix, J.C, Misra, S. 登録日 2013-04-23 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone. Protein Sci., 23, 2014
1YUW	crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant 分子名称: Heat shock cognate 71 kDa protein 著者 Jiang, J, Lafer, E.M, Prasad, K, Sousa, R. 登録日 2005-02-14 公開日 2005-10-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of interdomain communication in the Hsc70 chaperone Mol.Cell, 20, 2005
5TKY	Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein 著者 Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. 登録日 2016-10-10 公開日 2016-11-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun, 7, 2016
5UMB	Crystal structure of ATPase domain of Malaria GRP78 with ADP bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ... 著者 Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H. 登録日 2017-01-26 公開日 2022-07-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Repurposing drugs to target the malaria parasite unfolding protein response. Sci Rep, 8, 2018
5MB9	Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I. 登録日 2016-11-07 公開日 2016-12-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex. Nat. Struct. Mol. Biol., 24, 2017
5MKS	HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation 分子名称: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, Heat shock 70 kDa protein 1A 著者 Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. 登録日 2016-12-05 公開日 2017-03-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
6SR6	Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... 著者 Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. 登録日 2019-09-05 公開日 2020-03-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
6RZQ	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state 分子名称: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ... 著者 Vakonakis, I, Day, J. 登録日 2019-06-13 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
5MKR	HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation 分子名称: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, CITRATE ANION, Heat shock 70 kDa protein 1A 著者 Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. 登録日 2016-12-05 公開日 2017-03-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
6S02	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION 著者 Vakonakis, I, Day, J. 登録日 2019-06-13 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
7P31	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818 分子名称: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ... 著者 Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. 登録日 2021-07-06 公開日 2021-07-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with small molecule ligands To Be Published
4EZN	Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin 分子名称: Chaperone protein DnaK, Pyrrhocoricin 著者 Zahn, M, Straeter, N. 登録日 2012-05-03 公開日 2013-04-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4EZX	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the designer peptide NRLMLTG 分子名称: Chaperone protein DnaK, SULFATE ION, synthetic peptide NRLMLTG 著者 Zahn, M, Straeter, N. 登録日 2012-05-03 公開日 2013-04-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013

 

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