3PDF
 
 | | Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C | | 分子名称: | 2,5-dibromo-N-{(3R,5S)-1-[(Z)-iminomethyl]-5-methylpyrrolidin-3-yl}benzenesulfonamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, B, Laine, D. | | 登録日 | 2010-10-22 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of novel cyanamide-based inhibitors of cathepsin C.
Acs Med.Chem.Lett., 2, 2011
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1FT6
 | | REDUCED STATE OF CYTOCHROME C554 FROM NITROSOMONAS EUROPAEA | | 分子名称: | CYTOCHROME C554, DITHIONITE, HEME C, ... | | 著者 | Iverson, T.M, Arciero, D.M, Hooper, A.B, Rees, D.C. | | 登録日 | 2000-09-11 | | 公開日 | 2000-09-20 | | 最終更新日 | 2021-03-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | High-resolution structures of the oxidized and reduced states of cytochrome c554 from Nitrosomonas europaea.
J.Biol.Inorg.Chem., 6, 2001
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1OKS
 | | Crystal structure of the measles virus phosphoprotein XD domain | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, RNA POLYMERASE ALPHA SUBUNIT | | 著者 | Johansson, K, Bourhis, J.-M, Campanacci, V, Cambillau, C, Canard, B, Longhi, S. | | 登録日 | 2003-07-29 | | 公開日 | 2003-09-01 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure of the Measles Virus Phosphoprotein Domain Responsible for the Induced Folding of the C-Terminal Domain of the Nucleoprotein
J.Biol.Chem., 278, 2003
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4JAJ
 | | Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE | | 分子名称: | Aurora kinase A, benzo[c][1,8]naphthyridin-6(5H)-one | | 著者 | Jiang, X, Josephson, K, Huck, B, Goutopoulos, A, Karra, S. | | 登録日 | 2013-02-18 | | 公開日 | 2013-05-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
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2M87
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3PSJ
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2FAK
 | | Crystal structure of Salinosporamide A in complex with the yeast 20S proteasome | | 分子名称: | (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE, Proteasome component C1, Proteasome component C11, ... | | 著者 | Groll, M, Potts, B.C. | | 登録日 | 2005-12-07 | | 公開日 | 2006-04-18 | | 最終更新日 | 2023-05-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding.
J.Am.Chem.Soc., 128, 2006
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2QYP
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3BJN
 | | Crystal structure of C-terminal domain of putative transcriptional regulator from Vibrio cholerae, targeted domain 79-240 | | 分子名称: | CHLORIDE ION, Transcriptional regulator, putative | | 著者 | Chang, C, Volkart, L, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2007-12-04 | | 公開日 | 2007-12-11 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal structure of C-terminal domain of putative transcriptional regulator from Vibrio cholerae.
To be Published
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3QIW
 | | Crystal structure of the 226 TCR in complex with MCC-p5E/I-Ek | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, E-K alpha chain, ... | | 著者 | Kruse, A.C, Ely, L.K, Newell, E.W, Davis, M.M, Garcia, K.C. | | 登録日 | 2011-01-27 | | 公開日 | 2011-04-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).
J.Immunol., 186, 2011
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4L3P
 | | Crystal Structure of 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine bound to TAK1-TAB1 | | 分子名称: | 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine, Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera | | 著者 | Wang, J, Hornberger, K.R, Crew, A.P, Steinbacher, S, Maskos, K, Moertl, M. | | 登録日 | 2013-06-06 | | 公開日 | 2013-06-19 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
Bioorg.Med.Chem.Lett., 23, 2013
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1Y8J
 | | Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor | | 分子名称: | 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | 著者 | Sahli, S, Frank, B, Schweizer, W.B, Diederich, F, Blum-Kaelin, D, Aebi, J.D, Bohm, H.J, Oefner, C, Dale, G.E. | | 登録日 | 2004-12-13 | | 公開日 | 2005-06-07 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-ray Crystal Structure Analysis
HELV.CHIM.ACTA, 88, 2005
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3Q9V
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3BI6
 | | Wee1 kinase complex with inhibitor PD352396 | | 分子名称: | 4-(2-chlorophenyl)-9-hydroxy-6-methyl-1,3-dioxo-N-(2-pyrrolidin-1-ylethyl)pyrrolo[3,4-g]carbazole-8-carboxamide, CHLORIDE ION, Wee1-like protein kinase | | 著者 | Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. | | 登録日 | 2007-11-29 | | 公開日 | 2007-12-18 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
Bioorg.Med.Chem.Lett., 18, 2008
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3E0K
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4JAI
 | | Crystal Structure of Aurora Kinase A in complex with N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide | | 分子名称: | Aurora kinase A, N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide | | 著者 | Jiang, X, Josephson, K, Huck, B, Goutopoulos, A, Karra, S. | | 登録日 | 2013-02-18 | | 公開日 | 2013-05-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
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3RNY
 | | Crystal structure of human RSK1 C-terminal kinase domain | | 分子名称: | Ribosomal protein S6 kinase alpha-1, SODIUM ION | | 著者 | Li, D, Fu, T.-M, Nan, J, Su, X.-D. | | 登録日 | 2011-04-24 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1.
Acta Crystallogr.,Sect.D, 68, 2012
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2K8Z
 | | Dimeric solution structure of the DNA loop d(TCGTTGCT) | | 分子名称: | 5'-D(*TP*CP*GP*TP*TP*GP*CP*T)-3' | | 著者 | Viladoms, J, Escaja, N, Frieden, M, Gomez-Pinto, I, Pedroso, E, Gonzalez, C. | | 登録日 | 2008-09-29 | | 公開日 | 2009-04-28 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Self-association of short DNA loops through minor groove C:G:G:C tetrads.
Nucleic Acids Res., 37, 2009
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4GV9
 | | Lassa nucleoprotein C-terminal domain in complex with triphosphated dsRNA soaking for 5 min | | 分子名称: | MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ... | | 著者 | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | | 登録日 | 2012-08-30 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
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2MTS
 | | Three-Dimensional Structure and Interaction Studies of Hepatitis C Virus p7 in 1,2-Dihexanoyl-sn-glycero-3-phosphocholine by Solution Nuclear Magnetic Resonance | | 分子名称: | HEPATITIS C VIRUS P7 PROTEIN | | 著者 | Cook, G.A, Dawson, L.A, Tian, Y, Opella, S.J. | | 登録日 | 2014-08-29 | | 公開日 | 2014-10-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Three-dimensional structure and interaction studies of hepatitis C virus p7 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine by solution nuclear magnetic resonance.
Biochemistry, 52, 2013
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2JWO
 | | A PHD finger motif in the C-terminus of RAG2 modulates recombination activity | | 分子名称: | V(D)J recombination-activating protein 2, ZINC ION | | 著者 | Ivanov, D, Hyberts, S.G, Sun, Z, Wagner, G. | | 登録日 | 2007-10-17 | | 公開日 | 2007-11-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A PHD finger motif in the C terminus of RAG2 modulates recombination activity.
J.Biol.Chem., 280, 2005
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2K1S
 | | Solution NMR structure of the folded C-terminal fragment of YiaD from Escherichia coli. Northeast Structural Genomics Consortium target ER553. | | 分子名称: | Inner membrane lipoprotein yiaD | | 著者 | Ramelot, T.A, Zhao, L, Hamilton, K, Maglaqui, M, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2008-03-14 | | 公開日 | 2008-05-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR structure of the folded C-terminal fragment of YiaD from Escherichia coli. Northeast Structural Genomics Consortium target ER553.
To be Published
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1IJS
 | | CPV (STRAIN D) mutant A300D, complex (VIRAL COAT/DNA), VP2, PH=7.5, T=4 DEGREES C | | 分子名称: | DNA (5'-D(*AP*C)-3'), DNA (5'-D(*CP*CP*AP*CP*CP*CP*CP*AP*A)-3'), PROTEIN (PARVOVIRUS COAT PROTEIN) | | 著者 | Llamas-Saiz, A.L, Agbandje-McKenna, M, Parker, J.S.L, Wahid, A.T.M, Parrish, C.R, Rossmann, M.G. | | 登録日 | 1996-09-12 | | 公開日 | 1996-12-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Structural analysis of a mutation in canine parvovirus which controls antigenicity and host range.
Virology, 225, 1996
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1SBS
 | | CRYSTAL STRUCTURE OF AN ANTI-HCG FAB | | 分子名称: | MONOCLONAL ANTIBODY 3A2, SULFATE ION | | 著者 | Fotinou, C, Beauchamp, J, Emsley, P, Dehaan, A, Schielen, W.J.G, Bos, E, Isaacs, N.W. | | 登録日 | 1998-04-08 | | 公開日 | 1999-04-13 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of an Fab fragment against a C-terminal peptide of hCG at 2.0 A resolution.
J.Biol.Chem., 273, 1998
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2K90
 | | Dimeric solution structure of the DNA loop d(TGCTTCGT) | | 分子名称: | 5'-D(*TP*GP*CP*TP*TP*CP*GP*T)-3' | | 著者 | Viladoms, J, Escaja, N, Frieden, M, Gomez-Pinto, I, Pedroso, E, Gonzalez, C. | | 登録日 | 2008-09-29 | | 公開日 | 2009-04-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Self-association of short DNA loops through minor groove C:G:G:C tetrads.
Nucleic Acids Res., 37, 2009
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