3CFV
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![BU of 3cfv by Molmil](/molmil-images/mine/3cfv) | Structural basis of the interaction of RbAp46/RbAp48 with histone H4 | 分子名称: | ARSENIC, Histone H4 peptide, Histone-binding protein RBBP7 | 著者 | Pei, X.-Y, Murzina, N.V, Zhang, W, McLaughlin, S, Verreault, A, Luisi, B.F, Laue, E.D. | 登録日 | 2008-03-04 | 公開日 | 2008-06-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46. Structure, 16, 2008
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7ZTA
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![BU of 7zta by Molmil](/molmil-images/mine/7zta) | Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Leroy, E.C, Perry, T.N, Renault, T.T, Innis, C.A. | 登録日 | 2022-05-09 | 公開日 | 2023-04-12 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs. Nat.Chem.Biol., 19, 2023
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6GXP
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![BU of 6gxp by Molmil](/molmil-images/mine/6gxp) | Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP(RF3-only) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Graf, M, Huter, P, Maracci, C, Peterek, M, Rodnina, M.V, Wilson, D.N. | 登録日 | 2018-06-27 | 公開日 | 2018-08-15 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1. Nat Commun, 9, 2018
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6Q9A
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![BU of 6q9a by Molmil](/molmil-images/mine/6q9a) | |
5A2Q
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![BU of 5a2q by Molmil](/molmil-images/mine/5a2q) | Structure of the HCV IRES bound to the human ribosome | 分子名称: | 18S RRNA, HCV IRES, MAGNESIUM ION, ... | 著者 | Quade, N, Leiundgut, M, Boehringer, D, Heuvel, J.v.d, Ban, N. | 登録日 | 2015-05-21 | 公開日 | 2015-07-15 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-Em Structure of Hepatitis C Virus Ires Bound to the Human Ribosome at 3.9 Angstrom Resolution Nat.Commun., 6, 2015
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1RP3
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2DVY
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![BU of 2dvy by Molmil](/molmil-images/mine/2dvy) | Crystal structure of restriction endonucleases PabI | 分子名称: | Restriction endonuclease PabI | 著者 | Miyazono, K, Watanabe, M, Kamo, M, Sawasaki, T, Nagata, K, Endo, Y, Tanokura, M, Kobayashi, I. | 登録日 | 2006-08-01 | 公開日 | 2007-05-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Novel protein fold discovered in the PabI family of restriction enzymes Nucleic Acids Res., 35, 2007
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6NUW
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![BU of 6nuw by Molmil](/molmil-images/mine/6nuw) | Yeast Ctf19 complex | 分子名称: | Inner kinetochore subunit AME1, Inner kinetochore subunit CHL4, Inner kinetochore subunit CTF19, ... | 著者 | Hinshaw, S.M, Harrison, S.C. | 登録日 | 2019-02-03 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | The structure of the Ctf19c/CCAN from budding yeast. Elife, 8, 2019
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6OQI
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![BU of 6oqi by Molmil](/molmil-images/mine/6oqi) | CDK2 in complex with Cpd14 (5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl)-N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine) | 分子名称: | 5-fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[(4S)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine, Cyclin-dependent kinase 2 | 著者 | Murray, J.M. | 登録日 | 2019-04-26 | 公開日 | 2020-07-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg.Med.Chem.Lett., 29, 2019
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6NTW
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![BU of 6ntw by Molmil](/molmil-images/mine/6ntw) | Crystal structure of E. coli YcbB | 分子名称: | (2S,3R,4S)-4-{[(3S,5R)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Probable L,D-transpeptidase YcbB, SULFATE ION | 著者 | Caveney, N.A, Strynadka, N.C.J, Caballero, G, Worrall, L.J. | 登録日 | 2019-01-30 | 公開日 | 2019-03-20 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli. Nat Commun, 10, 2019
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5GHD
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![BU of 5ghd by Molmil](/molmil-images/mine/5ghd) | |
7QXX
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![BU of 7qxx by Molmil](/molmil-images/mine/7qxx) | Proteasome-ZFAND5 Complex Z+E state | 分子名称: | 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-27 | 公開日 | 2023-02-08 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Molecular mechanism for activation of the 26S proteasome by ZFAND5. Mol.Cell, 83, 2023
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7QXN
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![BU of 7qxn by Molmil](/molmil-images/mine/7qxn) | Proteasome-ZFAND5 Complex Z+A state | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-26 | 公開日 | 2023-02-08 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular mechanism for activation of the 26S proteasome by ZFAND5. Mol.Cell, 83, 2023
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7QY7
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![BU of 7qy7 by Molmil](/molmil-images/mine/7qy7) | Proteasome-ZFAND5 Complex Z-A state | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-27 | 公開日 | 2023-02-08 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Molecular mechanism for activation of the 26S proteasome by ZFAND5. Mol.Cell, 83, 2023
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7QYB
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![BU of 7qyb by Molmil](/molmil-images/mine/7qyb) | Proteasome-ZFAND5 Complex Z-C state | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-27 | 公開日 | 2023-02-08 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Molecular mechanism for activation of the 26S proteasome by ZFAND5. Mol.Cell, 83, 2023
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6EJW
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![BU of 6ejw by Molmil](/molmil-images/mine/6ejw) | Tryptophan Repressor TrpR from E.coli wildtype with Indole-3-acetic acid as ligand | 分子名称: | 1H-INDOL-3-YLACETIC ACID, Trp operon repressor | 著者 | Stiel, A.C, Shanmugaratnam, S, Herud-Sikimic, O, Juergens, G, Hocker, B. | 登録日 | 2017-09-23 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | A biosensor for the direct visualization of auxin Nature, 2021
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7QXP
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![BU of 7qxp by Molmil](/molmil-images/mine/7qxp) | Proteasome-ZFAND5 Complex Z+B state | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-26 | 公開日 | 2023-02-08 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Molecular mechanism for activation of the 26S proteasome by ZFAND5. Mol.Cell, 83, 2023
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7QXU
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![BU of 7qxu by Molmil](/molmil-images/mine/7qxu) | Proteasome-ZFAND5 Complex Z+C state | 分子名称: | 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-27 | 公開日 | 2023-02-08 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Molecular mechanism for activation of the 26S proteasome by ZFAND5. Mol.Cell, 83, 2023
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7QYA
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![BU of 7qya by Molmil](/molmil-images/mine/7qya) | Proteasome-ZFAND5 Complex Z-B state | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-27 | 公開日 | 2023-02-08 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Molecular mechanism for activation of the 26S proteasome by ZFAND5. Mol.Cell, 83, 2023
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6ELB
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![BU of 6elb by Molmil](/molmil-images/mine/6elb) | Tryptophan Repressor TrpR from E.coli variant M42F T44L T81M N87G S88Y with Indole-3-acetic acid as ligand | 分子名称: | 1H-INDOL-3-YLACETIC ACID, Trp operon repressor | 著者 | Stiel, A.C, Shanmugaratnam, S, Herud-Sikimic, O, Juergens, G, Hocker, B. | 登録日 | 2017-09-28 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.437 Å) | 主引用文献 | A biosensor for the direct visualization of auxin Nature, 2021
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5ML5
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![BU of 5ml5 by Molmil](/molmil-images/mine/5ml5) | Human p38alpha MAPK in complex with imidazolyl pyridine inhibitor 11b | 分子名称: | 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-methylsulfanyl-1~{H}-imidazol-5-yl]pyridin-2-yl]propanamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | 著者 | Buehrmann, M, Rauh, D. | 登録日 | 2016-12-06 | 公開日 | 2017-04-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK. Molecules, 22, 2017
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6ENI
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![BU of 6eni by Molmil](/molmil-images/mine/6eni) | Tryptophan Repressor TrpR from E.coli variant T44L S88Y with Indole-3-acetic acid as ligand | 分子名称: | 1,2-ETHANEDIOL, 1H-INDOL-3-YLACETIC ACID, Trp operon repressor | 著者 | Stiel, A.C, Shanmugaratnam, S, Herud-Sikimic, O, Juergens, G, Hocker, B. | 登録日 | 2017-10-04 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | A biosensor for the direct visualization of auxin Nature, 2021
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6ELG
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![BU of 6elg by Molmil](/molmil-images/mine/6elg) | Tryptophan Repressor TrpR from E.coli variant M42F T44L T81I S88Y with Indole-3-acetonitrile | 分子名称: | 1H-indol-3-ylacetonitrile, Trp operon repressor | 著者 | Stiel, A.C, Shanmugaratnam, S, Herud-Sikimic, O, Juergens, G, Hocker, B. | 登録日 | 2017-09-28 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | A biosensor for the direct visualization of auxin Nature, 2021
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7M4T
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![BU of 7m4t by Molmil](/molmil-images/mine/7m4t) | Menin bound to M-1121 | 分子名称: | Menin, methyl {(1S,2R)-2-[(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-{1-[(3-methoxy-1-{4-[(1S,4S)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptane-2-sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}ethyl]cyclopentyl}carbamate, praseodymium triacetate | 著者 | Stuckey, J. | 登録日 | 2021-03-22 | 公開日 | 2021-08-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression. J.Med.Chem., 64, 2021
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5MTX
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![BU of 5mtx by Molmil](/molmil-images/mine/5mtx) | Dibenzooxepinone inhibitor 12b in complex with p38 MAPK | 分子名称: | 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-6~{H}-benzo[c][1]benzoxepine-9-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | 著者 | Buehrmann, M, Rauh, D. | 登録日 | 2017-01-11 | 公開日 | 2017-09-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Novel Type I(1)/2 p38 alpha MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine. J. Med. Chem., 60, 2017
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