8W4C
 
 | | The sigma-1 receptor from Xenopus laevis in complex with progesterone by soaking | | 分子名称: | PROGESTERONE, Sigma non-opioid intracellular receptor 1 | | 著者 | Xiao, Y, Fu, C, Sun, Z, Zhou, X. | | 登録日 | 2023-08-23 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.676 Å) | | 主引用文献 | Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.
Nat Commun, 15, 2024
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9AZA
 | | Crystal structure of LolTv4 | | 分子名称: | Aminotransferase, class V/Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Gao, J, Hai, Y. | | 登録日 | 2024-03-10 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Enzymatic Synthesis of Unprotected alpha , beta-Diamino Acids via Direct Asymmetric Mannich Reactions.
J.Am.Chem.Soc., 146, 2024
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8XN7
 | | Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f | | 分子名称: | 5-amino-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-8-(2-(trifluoromethyl)benzyl)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase kinase kinase kinase 1 | | 著者 | Huang, W.X, Liu, R, Ding, K. | | 登録日 | 2023-12-29 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors.
Eur.J.Med.Chem., 269, 2024
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8OOK
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8XS4
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9B27
 | | Dia1 at the Barbed End of F-Actin | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Palmer, N.J, Barrie, K.R, Dominguez, R. | | 登録日 | 2024-03-14 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | | 主引用文献 | Mechanisms of actin filament severing and elongation by formins.
Nature, 632, 2024
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8OUT
 | | CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 22 | | 分子名称: | (1R)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-fluoranyl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2,2,2-tris(fluoranyl)ethanol, Mitogen-activated protein kinase kinase kinase 12 | | 著者 | Zebisch, M, Akkermans, O, Barker, J.J, Cross, J.B. | | 登録日 | 2023-04-24 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.935 Å) | | 主引用文献 | Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
J.Med.Chem., 66, 2023
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8W4B
 | | The sigma-1 receptor from Xenopus laevis in complex with progesterone by co-crystallization | | 分子名称: | PROGESTERONE, Sigma non-opioid intracellular receptor 1 | | 著者 | Xiao, Y, Fu, C, Sun, Z, Zhou, X. | | 登録日 | 2023-08-23 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.152 Å) | | 主引用文献 | Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.
Nat Commun, 15, 2024
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9CBE
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9BUV
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8WUE
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9BD0
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8P3O
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8XW1
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8YPJ
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9FZ4
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8WV5
 | | C-reactive protein, decamer | | 分子名称: | C-reactive protein(1-205), CALCIUM ION | | 著者 | Yadav, S, Vinothkumar, K.R. | | 登録日 | 2023-10-23 | | 公開日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Factors affecting macromolecule orientations in thin films formed in cryo-EM.
Acta Crystallogr D Struct Biol, 80, 2024
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8P25
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8VJ1
 | | Structure of C-terminal domain of telomere resolvase, ResT, from Borrelia garinii | | 分子名称: | Telomere resolvase ResT | | 著者 | Semper, C, Savchenko, A, Watanabe, N, Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Structure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain.
Nucleic Acids Res., 52, 2024
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8Y8Z
 | | Structure of NET-Maprotiline in outward-open state | | 分子名称: | CHLORIDE ION, SODIUM ION, Sodium-dependent noradrenaline transporter, ... | | 著者 | Zhang, H, Xu, E.H, Jiang, Y. | | 登録日 | 2024-02-06 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter.
Nature, 630, 2024
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9ERO
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8W4E
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8P8C
 | | HUMAN CD38 ECTODOMAIN BOUND TO COMPOUND 9-ADPR ADDUCT | | 分子名称: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[4-[4-[[4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-2-oxidanylidene-quinolin-6-yl]pyrazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | | 著者 | Rangel, V, Zebisch, M, Doyle, K.J, Burli, R.W. | | 登録日 | 2023-05-31 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.653 Å) | | 主引用文献 | A Covalent Binding Mode of a Pyrazole-Based CD38 Inhibitor
Helv.Chim.Acta, 106, 2023
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8WXF
 | | PNPase of Mycobacterium tuberculosis | | 分子名称: | Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase | | 著者 | Wang, N, Sheng, Y.N, Liu, Y.T. | | 登録日 | 2023-10-29 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation.
Arch.Biochem.Biophys., 754, 2024
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9FE0
 | | Crystal Structure of reduced NuoEF variant R66G(NuoF) from Aquifex aeolicus bound to NAD+ | | 分子名称: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S. | | 登録日 | 2024-05-17 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochim Biophys Acta Bioenerg, 1865, 2024
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