PDB: 494 件ウェブページステータス検索Chemie searchBIRD

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7RFX	Importin alpha2 in complex with MERS ORF4B 分子名称: Importin subunit alpha-1, ORF4b 著者 Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. 登録日 2021-07-14 公開日 2021-07-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
7RG2	Importin alpha2 in complex with MERS ORF4B R33A mutant 分子名称: Importin subunit alpha-1, ORF4b 著者 Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. 登録日 2021-07-14 公開日 2021-08-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
7RG6	Importin alpha2 in complex with ORF4B Bat coronavirus HKU5 分子名称: Importin subunit alpha-1, Non-structural protein ORF4b 著者 Foster, J.K, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. 登録日 2021-07-14 公開日 2021-08-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
7RG3	Importin alpha2 in complex with MERS ORF4B R37A mutant 分子名称: Importin subunit alpha-1, ORF4b 著者 Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. 登録日 2021-07-14 公開日 2021-08-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
7RG4	Importin alpha2 in complex with p50 NLS 分子名称: Importin subunit alpha-1, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit 著者 Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. 登録日 2021-07-14 公開日 2021-08-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
7RG5	Importin alpha3 in complex with p50 NLS 分子名称: Importin subunit alpha-3, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit 著者 Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. 登録日 2021-07-14 公開日 2021-08-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
8FUC	Crystal structure of mouse Importin alpha in complex with Hendra virus matrix protein minor site NLS2 分子名称: Contaminant peptide KKLARE, Importin subunit alpha-1, Matrix protein 著者 Donnelly, C.M, Basler, C.F, Scott, C, Forwood, J.K. 登録日 2023-01-17 公開日 2023-01-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism. Viruses, 15, 2023
7RFZ	Importin alpha 2 in complex with MERS ORF4B NLS peptide 分子名称: Importin subunit alpha-1, ORF4b 著者 Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. 登録日 2021-07-14 公開日 2021-07-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
1Z3H	The exportin Cse1 in its cargo-free, cytoplasmic state 分子名称: Importin alpha re-exporter, MAGNESIUM ION 著者 Cook, A, Fernandez, E, Lindner, D, Ebert, J, Schlenstedt, G, Conti, E. 登録日 2005-03-12 公開日 2005-05-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding Mol.Cell, 18, 2005
7JJL	Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS 分子名称: Importin subunit alpha-3, Lysine-specific histone demethylase 1A 著者 Tu, W.J, McCuaig, R, Tan, H.Y.A, Hardy, K, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S. 登録日 2020-07-27 公開日 2020-08-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch. Front Immunol, 11, 2020
6Q84	Crystal structure of RanGTP-Pdr6-eIF5A export complex 分子名称: Eukaryotic translation initiation factor 5A-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Aksu, M, Trakhanov, S, Vera-Rodriguez, A, Gorlich, D. 登録日 2018-12-14 公開日 2019-05-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. J.Cell Biol., 218, 2019
6Q82	Crystal structure of the biportin Pdr6 in complex with RanGTP 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin beta-like protein KAP122, ... 著者 Aksu, M, Vera-Rodriguez, A, Trakhanov, S, Gorlich, D. 登録日 2018-12-14 公開日 2019-05-01 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.994 Å) 主引用文献 Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. J.Cell Biol., 218, 2019
8SV0	The crystal structure of the classical binding interface of Importin alpha 2 and nuclear localisation signal sequence in Psittacine siadenovirus core protein VII 分子名称: Importin subunit alpha-1, SODIUM ION, protein VII 著者 Athukorala, A, Sarker, S, Forwood, J.K, Donnelly, C.M. 登録日 2023-05-14 公開日 2023-05-31 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and functional characterization of nuclear localization signal of pVII protein of psittacine siadenovirus F demonstrates an independent transport of pVII protein into the nucleus To Be Published
4YI0	Structure of mouse importin a1 bound to Pom121NLS 分子名称: Importin subunit alpha-1, Nuclear envelope pore membrane protein POM 121 著者 Lokareddy, R.K, Cingolani, G. 登録日 2015-02-27 公開日 2016-01-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.806 Å) 主引用文献 Mammalian Pom121 and yeast Heh2 share IBB-like NLSs that support targeting to the inner nuclear membrane To Be Published
8U36	The crystal structure of the classical binding interface of Importin alpha 2 and a nuclear localisation signal sequence in Frog siadenovirus core protein VII 分子名称: Importin subunit alpha-1, PVII, SODIUM ION 著者 Athukorala, A, Donnelly, C.M, Forwood, J.K, Sarker, S. 登録日 2023-09-07 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and functional characterization of nuclear localization signals of pVII protein of Frog siadenovirus To be published
5D5K	Crystal Structure NLS from human PARP-2 complexed with Importin alpha delta IBB 分子名称: Importin subunit alpha-1, Poly [ADP-ribose] polymerase 2 著者 Riccio, A.A, Cingolani, G, Pascal, J.M. 登録日 2015-08-10 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Res., 44, 2016
6WX8	SOX2 bound to Importin-alpha 3 分子名称: Importin subunit alpha-3, SULFATE ION, Transcription factor SOX-2 著者 Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. 登録日 2020-05-10 公開日 2020-10-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
6WX9	SOX2 bound to Importin-alpha 5 分子名称: Importin subunit alpha-5, Transcription factor SOX-2 著者 Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. 登録日 2020-05-10 公開日 2020-10-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
6WX7	SOX2 bound to Importin-alpha 2 分子名称: Importin subunit alpha-1, Transcription factor SOX-2 著者 Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. 登録日 2020-05-09 公開日 2020-10-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
5H2X	Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-172) 分子名称: Importin subunit alpha, Ubiquitin-like-specific protease 1 著者 Hirano, H, Matsuura, Y. 登録日 2016-10-18 公開日 2016-12-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p J. Mol. Biol., 429, 2017
5H2W	Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340) 分子名称: Importin subunit alpha, Ubiquitin-like-specific protease 1 著者 Hirano, H, Matsuura, Y. 登録日 2016-10-18 公開日 2016-12-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p J. Mol. Biol., 429, 2017
5H2V	Crystal structure of the karyopherin Kap121p bound to the SUMO protease Ulp1p 分子名称: Importin subunit beta-3, Ubiquitin-like-specific protease 1 著者 Kobayashi, J, Matsuura, Y. 登録日 2016-10-18 公開日 2016-12-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p J. Mol. Biol., 429, 2017
2BKU	Kap95p:RanGTP complex 分子名称: GTP-BINDING NUCLEAR PROTEIN RAN, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN BETA-1 SUBUNIT, ... 著者 Lee, S.J, Matsuura, Y, Liu, S.M, Stewart, M. 登録日 2005-02-21 公開日 2005-05-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis for Nuclear Import Complex Dissociation by Rangtp Nature, 435, 2005
5HUY	Structure of HCMV Small Terminase NLS bound to importin alpha 分子名称: HCMV small terminase, Importin subunit alpha-1 著者 Sankhala, R.S, Lokareddy, R.K, Cingolani, G. 登録日 2016-01-28 公開日 2016-03-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.979 Å) 主引用文献 Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J.Biol.Chem., 291, 2016
5HUW	Structure of HSV-1 Large Terminase NLS bound to importin alpha 分子名称: HSV1 large terminase NLS, Importin subunit alpha-1 著者 Sankhala, R.S, Lokareddy, R.K, Cingolani, G. 登録日 2016-01-27 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J.Biol.Chem., 291, 2016

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