3OGJ
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![BU of 3ogj by Molmil](/molmil-images/mine/3ogj) | Crystal structure of partial apo (92-227) of cGMP-dependent protein kinase | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, PRKG1 protein | 著者 | Kim, J.J, Huang, G, Kwon, T.K, Zwart, P, Headd, J, Kim, C. | 登録日 | 2010-08-16 | 公開日 | 2011-05-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | 主引用文献 | Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding Plos One, 6, 2011
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8BX7
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![BU of 8bx7 by Molmil](/molmil-images/mine/8bx7) | Structure of the rod CNG channel bound to calmodulin | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1, calmodulin-1 | 著者 | Marino, J. | 登録日 | 2022-12-08 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel. Proc.Natl.Acad.Sci.USA, 120, 2023
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6HQ3
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![BU of 6hq3 by Molmil](/molmil-images/mine/6hq3) | |
4WBB
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![BU of 4wbb by Molmil](/molmil-images/mine/4wbb) | Single Turnover Autophosphorylation Cycle of the PKA RIIb Holoenzyme | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... | 著者 | Zhang, P, Knape, M.J, Ahuja, L.G, Keshwani, M.M, King, C.C, Sastri, M, Herberg, F.W, Taylor, S.S. | 登録日 | 2014-09-02 | 公開日 | 2015-05-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Single Turnover Autophosphorylation Cycle of the PKA RII beta Holoenzyme. Plos Biol., 13, 2015
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7T4X
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![BU of 7t4x by Molmil](/molmil-images/mine/7t4x) | |
1O3T
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![BU of 1o3t by Molmil](/molmil-images/mine/1o3t) | PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES | 分子名称: | 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*TP*CP*G)-3', 5'-D(*GP*CP*GP*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | 著者 | Chen, S, Vojtechovsky, J, Parkinson, G.N, Ebright, R.H, Berman, H.M. | 登録日 | 2003-03-18 | 公開日 | 2003-04-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex:
DNA Binding Specificity Based on Energetics of DNA Kinking J.Mol.Biol., 314, 2001
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4MGI
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![BU of 4mgi by Molmil](/molmil-images/mine/4mgi) | Selective activation of Epac1 and Epac2 | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ... | 著者 | Rehmann, H. | 登録日 | 2013-08-28 | 公開日 | 2014-09-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Selective activation of Epac1 and Epac2 To be Published
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7WM1
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![BU of 7wm1 by Molmil](/molmil-images/mine/7wm1) | Cryo-EM structure of AKT1-AtKC1 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium channel AKT1, ... | 著者 | Dongliang, L, Zijie, Z, Yannan, Q, Yuyue, T, Huaizong, S. | 登録日 | 2022-01-14 | 公開日 | 2023-01-25 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the regulation mechanism of a hyper polarization-activated K+ channel AKT1 by AtKC1 To Be Published
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2OZ6
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![BU of 2oz6 by Molmil](/molmil-images/mine/2oz6) | |
1ZRE
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![BU of 1zre by Molmil](/molmil-images/mine/1zre) | 4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6G;17C]ICAP38 DNA | 分子名称: | 5'-D(*AP*TP*TP*TP*CP*GP*AP*AP*AP*AP*AP*TP*GP*GP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*CP*CP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*AP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | 著者 | Berman, H.M, Napoli, A.A. | 登録日 | 2005-05-19 | 公開日 | 2006-03-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps. J.Mol.Biol., 357, 2006
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1RGS
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![BU of 1rgs by Molmil](/molmil-images/mine/1rgs) | REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP DEPENDENT PROTEIN KINASE | 著者 | Su, Y, Dostmann, W.R.G, Herberg, F.W, Durick, K, Xuong, N.-H, Ten Eyck, L, Taylor, S.S, Varughese, K.I. | 登録日 | 1995-06-21 | 公開日 | 1996-12-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science, 269, 1995
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1ZRC
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![BU of 1zrc by Molmil](/molmil-images/mine/1zrc) | 4 Crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-ICAP38 DNA | 分子名称: | 5'-D(*AP*TP*TP*TP*CP*GP*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*AP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | 著者 | Berman, H.M, Napoli, A.A. | 登録日 | 2005-05-19 | 公開日 | 2006-03-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps. J.Mol.Biol., 357, 2006
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1ZRD
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![BU of 1zrd by Molmil](/molmil-images/mine/1zrd) | 4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6A;17T]ICAP38 DNA | 分子名称: | 5'-D(*AP*TP*TP*TP*CP*GP*AP*AP*AP*AP*AP*TP*GP*AP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*TP*CP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*AP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | 著者 | Berman, H.M, Napoli, A.A. | 登録日 | 2005-05-19 | 公開日 | 2006-03-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps. J.Mol.Biol., 357, 2006
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7FF8
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![BU of 7ff8 by Molmil](/molmil-images/mine/7ff8) | |
4AVC
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![BU of 4avc by Molmil](/molmil-images/mine/4avc) | Crystal structure of protein lysine acetyltransferase Rv0998 in complex with acetyl CoA and cAMP | 分子名称: | 1,2-ETHANEDIOL, ACETYL COENZYME *A, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | 著者 | Lee, H.J, Lang, P.T, Fortune, S.M, Sassetti, C.M, Alber, T. | 登録日 | 2012-05-24 | 公開日 | 2012-07-11 | 最終更新日 | 2012-08-22 | 実験手法 | X-RAY DIFFRACTION (2.806 Å) | 主引用文献 | Cyclic AMP Regulation of Protein Lysine Acetylation in Mycobacterium Tuberculosis. Nat.Struct.Mol.Biol., 19, 2012
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6HQ5
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![BU of 6hq5 by Molmil](/molmil-images/mine/6hq5) | Structure of EAL Enzyme Bd1971 - cAMP and cyclic-di-GMP bound form | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, ... | 著者 | Lovering, A.L, Cadby, I.T. | 登録日 | 2018-09-24 | 公開日 | 2019-07-31 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase. Embo J., 38, 2019
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2XGX
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![BU of 2xgx by Molmil](/molmil-images/mine/2xgx) | Crystal structure of transcription factor NtcA from Synechococcus elongatus (mercury derivative) | 分子名称: | 2-OXOGLUTARIC ACID, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLOBAL NITROGEN REGULATOR, ... | 著者 | Llacer, J.L, Castells, M.A, Rubio, V. | 登録日 | 2010-06-08 | 公開日 | 2010-08-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii. Proc.Natl.Acad.Sci.USA, 107, 2010
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7RHG
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![BU of 7rhg by Molmil](/molmil-images/mine/7rhg) | Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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7RHJ
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![BU of 7rhj by Molmil](/molmil-images/mine/7rhj) | Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state | 分子名称: | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, ... | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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7RTF
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![BU of 7rtf by Molmil](/molmil-images/mine/7rtf) | SthK R120A Closed State | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | 著者 | Gao, X, Nimigean, C. | 登録日 | 2021-08-13 | 公開日 | 2022-11-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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3CO2
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7TJ6
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![BU of 7tj6 by Molmil](/molmil-images/mine/7tj6) | SthK open state, cAMP-bound in the presence of POPA | 分子名称: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | 著者 | Schmidpeter, P.A, Nimigean, C.M. | 登録日 | 2022-01-14 | 公開日 | 2022-10-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nat.Struct.Mol.Biol., 29, 2022
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7N15
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![BU of 7n15 by Molmil](/molmil-images/mine/7n15) | Structure of TAX-4_R421W w/cGMP open state | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ... | 著者 | Zheng, X, Li, H, Hu, Z, Su, D, Yang, J. | 登録日 | 2021-05-27 | 公開日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel. Commun Biol, 5, 2022
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2H6C
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7LFW
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![BU of 7lfw by Molmil](/molmil-images/mine/7lfw) | |