6ZSO
 
 | | Solution structure of the water-soluble LU-domain of human Lypd6b protein | | 分子名称: | Ly6/PLAUR domain-containing protein 6B | | 著者 | Tsarev, A.V, Kulbatskii, D.S, Paramonov, A.S, Lyukmanova, E.N, Shenkarev, Z.O. | | 登録日 | 2020-07-16 | | 公開日 | 2021-01-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors.
Int J Mol Sci, 21, 2020
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4UY2
 | | Crystal structure of the complex of the extracellular domain of human alpha9 nAChR with alpha-bungarotoxin. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-BUNGAROTOXIN ISOFORM V31, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9 | | 著者 | Giastas, P, Zouridakis, M, Zarkadas, E, Tzartos, S.J. | | 登録日 | 2014-08-28 | | 公開日 | 2014-10-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.697 Å) | | 主引用文献 | Crystal Structures of Free and Antagonist-Bound States of Human Alpha9 Nicotinic Receptor Extracellular Domain
Nat.Struct.Mol.Biol., 21, 2014
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6ZFM
 | | Structure of alpha-Cobratoxin with a peptide inhibitor | | 分子名称: | 3-[2-[2-[2-[2-[2-(2-azanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propan-1-ol, Alpha-cobratoxin, PENTAETHYLENE GLYCOL, ... | | 著者 | Kiontke, S, Kummel, D. | | 登録日 | 2020-06-17 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Peptide Inhibitors of the alpha-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.
J.Med.Chem., 63, 2020
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9BAF
 | | Solution NMR structure of conofurin-Delta | | 分子名称: | Alpha-conotoxin LvIA | | 著者 | Harvey, P.J, Craik, D.J, Hone, A.J, McIntosh, J.M. | | 登録日 | 2024-04-04 | | 公開日 | 2024-07-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors.
J.Med.Chem., 67, 2024
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6HY7
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6D9H
 | | Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist | | 分子名称: | ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Draper-Joyce, C.J, Khoshouei, M, Thal, D.M, Liang, Y.-L, Nguyen, A.T.N, Furness, S.G.B, Venugopal, H, Baltos, J, Plitzko, J.M, Danev, R, Baumeister, W, May, L.T, Wootten, D, Sexton, P, Glukhova, A, Christopoulos, A. | | 登録日 | 2018-04-29 | | 公開日 | 2018-06-20 | | 最終更新日 | 2018-07-11 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure of the adenosine-bound human adenosine A1receptor-Gicomplex.
Nature, 558, 2018
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1IM1
 | | NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1, 20 STRUCTURES | | 分子名称: | ALPHA-CONOTOXIN IM1 | | 著者 | Rogers, J.P, Luginbuhl, P, Shen, G.S, Mccabe, R.T, Stevens, R.C, Wemmer, D.E. | | 登録日 | 1998-11-18 | | 公開日 | 1999-06-15 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors.
Biochemistry, 38, 1999
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5AIN
 | | Varenicline Interactions at the 5HT3 Receptor Ligand Binding Site are Revealed by 5HTBP | | 分子名称: | SOLUBLE ACETYLCHOLINE RECEPTOR, VARENICLINE | | 著者 | Price, K.L, Lillestol, R, Ulens, C, Lummis, S.C. | | 登録日 | 2015-02-16 | | 公開日 | 2015-03-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Varenicline Interactions at the 5-Ht3 Receptor Ligand Binding Site are Revealed by 5-Htbp.
Acs Chem Neurosci, 6, 2015
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2N99
 | | Solution structure of the SLURP-2, a secreted isoform of Lynx1 | | 分子名称: | Ly-6/neurotoxin-like protein 1 | | 著者 | Paramonov, A.S, Shenkarev, Z.O, Lyukmanova, E.N, Arseniev, A.S. | | 登録日 | 2015-11-11 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors.
Sci Rep, 6, 2016
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1IMI
 | | SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 | | 分子名称: | PROTEIN (ALPHA-CONOTOXIN IMI) | | 著者 | Maslennikov, I.V, Shenkarev, Z.O, Zhmak, M.N, Tsetlin, V.I, Ivanov, V.T, Arseniev, A.S. | | 登録日 | 1998-11-27 | | 公開日 | 1999-04-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors.
FEBS Lett., 444, 1999
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6UR8
 | | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, ... | | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | | 登録日 | 2019-10-22 | | 公開日 | 2020-04-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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6KN2
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1E74
 | | NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R11E | | 分子名称: | ALPHA-CONOTOXIN IM1(R11E) | | 著者 | Rogers, J.P, Luginbuhl, P, Pemberton, K, Harty, P, Wemmer, D.E, Stevens, R.C. | | 登録日 | 2000-08-24 | | 公開日 | 2000-12-27 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist
J.Mol.Biol., 304, 2000
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1E76
 | | NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT D5N | | 分子名称: | ALPHA-CONOTOXIN IM1(D5N) | | 著者 | Rogers, J.P, Luginbuhl, P, Pemberton, K, Harty, P, Wemmer, D.E, Stevens, R.C. | | 登録日 | 2000-08-24 | | 公開日 | 2000-12-27 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist
J.Mol.Biol., 304, 2000
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1E75
 | | NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R7L | | 分子名称: | ALPHA-CONOTOXIN IM1(R7L) | | 著者 | Rogers, J.P, Luginbuhl, P, Pemberton, K, Harty, P, Wemmer, D.E, Stevens, R.C. | | 登録日 | 2000-08-24 | | 公開日 | 2000-12-27 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist
J.Mol.Biol., 304, 2000
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4X9Z
 | | Dimeric conotoxin alphaD-GeXXA | | 分子名称: | alphaD-conotoxin GeXXA from the venom of Conus generalis | | 著者 | Xu, S, Zhang, T, Kompella, S, Adams, D, Ding, J, Wang, C. | | 登録日 | 2014-12-12 | | 公開日 | 2015-12-02 | | 最終更新日 | 2020-02-05 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Conotoxin alpha D-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors
Sci Rep, 5, 2015
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6IB6
 | | Solution structure of the water-soluble LU-domain of human Lypd6 protein | | 分子名称: | Ly6/PLAUR domain-containing protein 6 | | 著者 | Tsarev, A.V, Kulbatskii, D.S, Paramonov, A.S, Lyukmanova, E.N, Shenkarev, Z.O. | | 登録日 | 2018-11-29 | | 公開日 | 2019-12-18 | | 最終更新日 | 2021-01-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors.
Int J Mol Sci, 21, 2020
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1M2C
 | | THREE-DIMENSIONAL STRUCTURE OF ALPHA-CONOTOXIN MII, NMR, 14 STRUCTURES | | 分子名称: | ALPHA-CONOTOXIN MII | | 著者 | Shon, K.J, Koerber, S.C, Rivier, J.E, Olivera, B.M, Mcintosh, J.M. | | 登録日 | 1997-09-15 | | 公開日 | 1998-12-09 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors.
J.Biol.Chem., 271, 1996
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6KNO
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6KMY
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6KNP
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6KN3
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7N1Z
 | | NMR structure of native PnIA | | 分子名称: | Alpha-conotoxin PnIA | | 著者 | Conibear, A.C, Rosengren, K.J, Lee, H.S. | | 登録日 | 2021-05-28 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.
Rsc Med Chem, 12, 2021
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7N21
 | | NMR structure of AnIB-OH | | 分子名称: | Alpha-conotoxin AnIB | | 著者 | Conibear, A.C, Rosengren, K.J, Lee, H.S. | | 登録日 | 2021-05-28 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.
Rsc Med Chem, 12, 2021
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7N23
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