8H16
 
 | Structure of SARS-CoV-1 Spike Protein (S/native) at pH 5.5, Open Conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X. | 登録日 | 2022-09-30 | 公開日 | 2022-11-09 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.35534 Å) | 主引用文献 | Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes. Life Sci Alliance, 6, 2023
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8H0Y
 
 | Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Locked-112 Conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, LINOLEIC ACID, ... | 著者 | Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X. | 登録日 | 2022-09-30 | 公開日 | 2022-11-09 | 最終更新日 | 2024-11-06 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes. Life Sci Alliance, 6, 2023
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8H15
 
 | Structure of SARS-CoV-1 Spike Protein (S/native) at pH 5.5, Closed Conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X. | 登録日 | 2022-09-30 | 公開日 | 2022-11-09 | 最終更新日 | 2024-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.14182 Å) | 主引用文献 | Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes. Life Sci Alliance, 6, 2023
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8RU5
 
 | ATPase family AAA domain containing 2 with crystallization epitope mutations V1022R:Q1027E | 分子名称: | 1,2-ETHANEDIOL, ATPase family AAA domain-containing protein 2 | 著者 | Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC) | 登録日 | 2024-01-30 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants To Be Published
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5L6P
 
 | EphB3 kinase domain covalently bound to an irreversible inhibitor (compound 6) | 分子名称: | 1,4-DIETHYLENE DIOXIDE, Ephrin type-B receptor 3, ~{N}-(4-phenylazanylquinazolin-7-yl)ethanamide | 著者 | Schimpl, M, Overman, R, Kung, A, Chen, Y.-C, Ni, F, Zhu, J, Turner, M, Molina, H, Zhang, C. | 登録日 | 2016-05-30 | 公開日 | 2016-08-10 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3. J.Am.Chem.Soc., 138, 2016
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6WPM
 
 | Crystal structure of a putative oligosaccharide periplasmic-binding protein from Synechococcus sp. MITs9220 in complex with zinc | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ... | 著者 | Ford, B.A, Michie, K.A, Paulsen, I.T, Mabbutt, B.C, Shah, B.S. | 登録日 | 2020-04-27 | 公開日 | 2021-05-12 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Novel functional insights into a modified sugar-binding protein from Synechococcus MITS9220. Sci Rep, 12, 2022
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7Q1W
 
 | Ruminococcus gnavus ATC29149 endo-beta-1,4-galactosidase (RgGH98) E411A in complex with blood group A (BgA II) tetrasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ... | 著者 | Owen, C.D, Wu, H, Crost, E.H, van Bakel, W, Gascuena, A.M, Latousakis, D, Hicks, T, Walpole, S, Urbanowicz, P.A, Ndeh, D, Monaco, S, Salom, L.S, Griffiths, R, Colvile, A, Spencer, D.I.R, Walsh, M.A, Angulo, J, Juge, N. | 登録日 | 2021-10-21 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract. Plos Biol., 19, 2021
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8UV1
 
 | Structure of TDP1 complexed with compound IB01 | 分子名称: | 1,2-ETHANEDIOL, 8-(fluorosulfonyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke, T.R. | 登録日 | 2023-11-02 | 公開日 | 2024-09-25 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structure of TDP1 complexed with compound IB01 To Be Published
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1EIC
 
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8UZV
 
 | Structure of TDP1 catalytic domain complexed with compound IB02 | 分子名称: | 1,2-ETHANEDIOL, 8-{[2-(fluorosulfonyl)ethyl]amino}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... | 著者 | Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. | 登録日 | 2023-11-16 | 公開日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (1.846 Å) | 主引用文献 | Structure of TDP1 catalytic domain complexed with compound IB02 To Be Published
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6WXN
 
 | EGFR(T790M/V948R) in complex with LN3844 | 分子名称: | CHLORIDE ION, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Heppner, D.E, Eck, M.J. | 登録日 | 2020-05-11 | 公開日 | 2021-05-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J.Med.Chem., 65, 2022
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8V0B
 
 | Structure of TDP1 catalytic domain complexed with compound IB05 | 分子名称: | 1,2-ETHANEDIOL, 8-{4-[(fluorosulfonyl)oxy]phenyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... | 著者 | Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. | 登録日 | 2023-11-17 | 公開日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structures of TDP1 complexed with inhibitors To Be Published
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6ZAY
 
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8ECE
 
 | E. coli L-asparaginase II mutant (V27T) in complex with L-Glu | 分子名称: | 1,2-ETHANEDIOL, GLUTAMIC ACID, L-asparaginase 2 | 著者 | Strzelczyk, P, Wlodawer, A, Lubkowski, J. | 登録日 | 2022-09-01 | 公開日 | 2022-11-16 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | The E. coli L-asparaginase V27T mutant: structural and functional characterization and comparison with theoretical predictions. Febs Lett., 596, 2022
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6ZJA
 
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6ZJ9
 
 | Crystal structure of Equus ferus caballus glutathione transferase A3-3 in complex with glutathione | 分子名称: | 1,2-ETHANEDIOL, GLUTATHIONE, Glutathione S-transferase | 著者 | Skerlova, J, Ismail, A, Lindstrom, H, Sjodin, B, Mannervik, B, Stenmark, P. | 登録日 | 2020-06-28 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and functional analysis of the inhibition of equine glutathione transferase A3-3 by organotin endocrine disrupting pollutants. Environ Pollut, 268, 2021
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8H7F
 
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6WGO
 
 | The interaction of dichlorido(3-(anthracen-9-ylmethyl)-1-methylimidazol-2-ylidene)(eta6-p-cymene)ruthenium(II) with HEWL after 1 week | 分子名称: | ACETATE ION, Lysozyme, SODIUM ION, ... | 著者 | Sullivan, M.P, Hartinger, C.G, Goldstone, D.C. | 登録日 | 2020-04-06 | 公開日 | 2021-10-06 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Anthracenyl Functionalization of Half-Sandwich Carbene Complexes: In Vitro Anticancer Activity and Reactions with Biomolecules. Inorg.Chem., 60, 2021
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8V6W
 
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4X7L
 
 | Co-crystal Structure of PERK bound to 4-{2-amino-4-methyl-3-[2-(methylamino)-1,3-benzothiazol-6-yl]benzoyl}-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one inhibitor | 分子名称: | 4-{2-amino-4-methyl-3-[2-(methylamino)-1,3-benzothiazol-6-yl]benzoyl}-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one, Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3, GLYCEROL, ... | 著者 | Shaffer, P.L, Long, A.M, Chen, H. | 登録日 | 2014-12-09 | 公開日 | 2015-01-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK). J.Med.Chem., 58, 2015
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4TS3
 
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8T92
 
 | Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and scyllo-D-(1,2,3,4)-IP4 | 分子名称: | (1S,2R,3R,4S,5R,6R)-5,6-dihydroxycyclohexane-1,2,3,4-tetrayl tetrakis[dihydrogen (phosphate)], ADENOSINE-5'-DIPHOSPHATE, Kinase, ... | 著者 | Zong, G, Wang, H, Shears, S.B. | 登録日 | 2023-06-23 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T95
 
 | Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and scyllo-(1,2,4,5)-IP4 | 分子名称: | (1S,3R,4R,6S)-1,3,4,6-TETRAPKISPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Kinase, ... | 著者 | Zong, G, Wang, H, Shears, S.B. | 登録日 | 2023-06-23 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T8Y
 
 | Crystal structure of Terrestrivirus inositol pyrophosphate kinase in complex with ADP and 1,4,5-InsP3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Kinase, ... | 著者 | Zong, G, Wang, H, Shears, S.B. | 登録日 | 2023-06-23 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8VRH
 
 | E. coli peptidyl-prolyl cis-trans isomerase containing delta2-monofluoro-leucines | 分子名称: | 1,2-ETHANEDIOL, 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Frkic, R.L, Jackson, C.J. | 登録日 | 2024-01-22 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Conformational Preferences of the Non-Canonical Amino Acids (2 S ,4 S )-5-Fluoroleucine, (2 S ,4 R )-5-Fluoroleucine, and 5,5'-Difluoroleucine in a Protein. Biochemistry, 63, 2024
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