9ASX
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6Z8L
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![BU of 6z8l by Molmil](/molmil-images/mine/6z8l) | Alpha-Amylase in complex with probe fragments | 分子名称: | CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase, ... | 著者 | Adam, S, Koehnke, J. | 登録日 | 2020-06-02 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.40000367 Å) | 主引用文献 | Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design. Chem Sci, 12, 2020
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4F56
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![BU of 4f56 by Molmil](/molmil-images/mine/4f56) | The bicyclic intermediate structure provides insights into the desuccinylation mechanism of SIRT5 | 分子名称: | 3-[(2R,3aR,5R,6R,6aR)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-2,6-dihydroxytetrahydrofuro[2,3-d][1,3]oxathiol-2-yl]propanoic acid, NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial, ... | 著者 | Zhou, Y, Hao, Q. | 登録日 | 2012-05-11 | 公開日 | 2012-06-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5) J.Biol.Chem., 287, 2012
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9BRY
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![BU of 9bry by Molmil](/molmil-images/mine/9bry) | V0-only V-ATPase in synaptophysin gene knock-out mouse brain isolated synaptic vesicles | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | 登録日 | 2024-05-12 | 公開日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex. Nature, 2024
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7M1P
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![BU of 7m1p by Molmil](/molmil-images/mine/7m1p) | Human ABCA4 structure in the unbound state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | 著者 | Scortecci, J.F, Van Petegem, F, Molday, R.S. | 登録日 | 2021-03-14 | 公開日 | 2021-09-08 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. Nat Commun, 12, 2021
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7M1Q
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![BU of 7m1q by Molmil](/molmil-images/mine/7m1q) | Human ABCA4 structure in complex with N-ret-PE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | 著者 | Scortecci, J.F, Van Petegem, F, Molday, R.S. | 登録日 | 2021-03-14 | 公開日 | 2021-09-08 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. Nat Commun, 12, 2021
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4F6A
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![BU of 4f6a by Molmil](/molmil-images/mine/4f6a) | High-resolution x-ray Structure of the tetramutant of BH1408 protein from Bacillus halodurans, Northeast Structural Genomics Consortium (NESG) Target BhR182 | 分子名称: | BH1408 protein, UNKNOWN LIGAND | 著者 | Kuzin, A, Neely, H, Odukwe, N, Seetharaman, J, Patel, P, Xiao, R, Kohan, E, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-05-14 | 公開日 | 2012-06-13 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.009 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target BhR182 To be Published
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9F9Z
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![BU of 9f9z by Molmil](/molmil-images/mine/9f9z) | Gcase in complex with small molecule inhibitor 1 | 分子名称: | (2~{S})-1-(2,6-dimethylphenoxy)propan-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lysosomal acid glucosylceramidase, ... | 著者 | Tisi, D, Cleasby, A. | 登録日 | 2024-05-09 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.279 Å) | 主引用文献 | Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of beta-Glucocerebrosidase. J.Med.Chem., 2024
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9FDI
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![BU of 9fdi by Molmil](/molmil-images/mine/9fdi) | Gcase in complex with small molecule inhibitor 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(phenylmethyl)piperidine, ... | 著者 | Tisi, D, Cleasby, A. | 登録日 | 2024-05-17 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of beta-Glucocerebrosidase. J.Med.Chem., 2024
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4FFX
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![BU of 4ffx by Molmil](/molmil-images/mine/4ffx) | Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency Associated Mutation | 分子名称: | Adenylosuccinate lyase | 著者 | Deaton, M.K, Ray, S.P, Capodagli, G.C, Calkins, L.A.F, Sawle, L, Ghosh, K, Patterson, D, Pegan, S.D. | 登録日 | 2012-06-01 | 公開日 | 2012-08-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation. Biochemistry, 51, 2012
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4FGY
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![BU of 4fgy by Molmil](/molmil-images/mine/4fgy) | Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity | 分子名称: | (4R,6S,8S,12R,14R,16Z,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma | 著者 | Wang, R, Li, Y. | 登録日 | 2012-06-05 | 公開日 | 2013-03-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. Diabetologia, 56, 2013
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3GZG
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4FJQ
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![BU of 4fjq by Molmil](/molmil-images/mine/4fjq) | Crystal Structure of an alpha-Bisabolol synthase | 分子名称: | Amorpha-4,11-diene synthase | 著者 | Jianxu, L, Peng, Z. | 登録日 | 2012-06-12 | 公開日 | 2013-03-13 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.0001 Å) | 主引用文献 | Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency. Biochem.J., 451, 2013
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6ZGX
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![BU of 6zgx by Molmil](/molmil-images/mine/6zgx) | Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N-(pyrimidin-2-yl)acetamide | 分子名称: | 1-[2-(2-oxidanylidenepyrrolidin-1-yl)ethyl]-3-phenyl-urea, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, ... | 著者 | Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. | 登録日 | 2020-06-20 | 公開日 | 2020-07-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia. Acs Chem.Biol., 16, 2021
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9C4I
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![BU of 9c4i by Molmil](/molmil-images/mine/9c4i) | Centrolobium microchaete seed lectin (CML) complexed with Man1-3Man-OMe | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | 著者 | Nascimento, K.S, Pinto-Junior, V.R, Lima, F.E.O, Osterne, V.J.S, Oliveira, M.V, Ferreira, V.M.S, Cavada, B.S. | 登録日 | 2024-06-04 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Centrolobium microchaete seed lectin (CML) complexed with Man1-3Man-OMe To Be Published
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9B8O
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![BU of 9b8o by Molmil](/molmil-images/mine/9b8o) | Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 3, Vo | 分子名称: | (7R)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOSAN-1-AMINIUM 4-OXIDE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Coupland, C.E, Rubinstein, J.L. | 登録日 | 2024-03-31 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles. Science, 2024
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4FBH
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![BU of 4fbh by Molmil](/molmil-images/mine/4fbh) | Structure of RIP from barley seeds | 分子名称: | ADENOSINE MONOPHOSPHATE, Protein synthesis inhibitor I | 著者 | Lee, B.-G, Kim, M.K, Suh, S.W, Song, H.K. | 登録日 | 2012-05-23 | 公開日 | 2012-10-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of the ribosome-inactivating protein from barley seeds reveal a unique activation mechanism. Acta Crystallogr.,Sect.D, 68, 2012
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9ATU
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9BRZ
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![BU of 9brz by Molmil](/molmil-images/mine/9brz) | V0-only V-ATPase and synaptophysin complex in mouse brain isolated synaptic vesicles | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | 登録日 | 2024-05-12 | 公開日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex. Nature, 2024
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4FLP
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![BU of 4flp by Molmil](/molmil-images/mine/4flp) | Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor JQ1 | 分子名称: | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, Bromodomain testis-specific protein, POTASSIUM ION | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, Canning, P, Muniz, J, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Bradner, J, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2012-06-15 | 公開日 | 2012-07-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Small-Molecule Inhibition of BRDT for Male Contraception. Cell(Cambridge,Mass.), 150, 2012
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4O3C
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![BU of 4o3c by Molmil](/molmil-images/mine/4o3c) | Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution | 分子名称: | ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ... | 著者 | Krintel, C, Frydenvang, K, Kaern, A.M, Gajhede, M, Kastrup, J.S. | 登録日 | 2013-12-18 | 公開日 | 2014-04-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
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4FDB
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![BU of 4fdb by Molmil](/molmil-images/mine/4fdb) | Three-dimensional structure of the protein prib from ralstonia solanacearum at the resolution 1.8a. northeast structural genomics consortium target rsr213c | 分子名称: | ACETIC ACID, Probable primosomal replication protein n | 著者 | Kuzin, A, Neely, H, Seetharaman, J, Wang, H, Sahdev, S, Foote, E.L, Xiao, R, Liu, J, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-05-27 | 公開日 | 2013-02-13 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Three-dimensional structure of the protein prib from ralstonia solanacearum at the resolution 1.8a. northeast structural genomics consortium target rsr213c To be Published
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4F3P
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7LT6
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9ATK
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