9EWO
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![BU of 9ewo by Molmil](/molmil-images/mine/9ewo) | Mpro from SARS-CoV-2 with R4A R298A double mutations | 分子名称: | Non-structural protein 11, SULFATE ION | 著者 | Plewka, J, Lis, K, Chykunova, Y, Czarna, A, Kantyka, T, Pyrc, K. | 登録日 | 2024-04-04 | 公開日 | 2024-04-17 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.002 Å) | 主引用文献 | SARS-CoV-2 M pro oligomerization as a potential target for therapy. Int.J.Biol.Macromol., 267, 2024
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8W6D
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![BU of 8w6d by Molmil](/molmil-images/mine/8w6d) | CryoEM structure of NaDC1 in apo state | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | 著者 | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | 登録日 | 2023-08-28 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism. Sci Adv, 10, 2024
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9EYX
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![BU of 9eyx by Molmil](/molmil-images/mine/9eyx) | Human PRMT5 in complex with AZ compound 28 | 分子名称: | (3~{S})-2-[(5-azanyl-6-fluoranyl-1~{H}-pyrrolo[3,2-b]pyridin-2-yl)methyl]-6-fluoranyl-1'-[(4-fluorophenyl)methyl]spiro[isoindole-3,3'-pyrrolidine]-1,2'-dione, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ... | 著者 | Debreczeni, J. | 登録日 | 2024-04-09 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. J.Med.Chem., 2024
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8WCT
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8WTC
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8XJJ
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8YLN
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![BU of 8yln by Molmil](/molmil-images/mine/8yln) | The structure of DSR2-Tail tube complex | 分子名称: | Bacillus phage SPR Tube protein, SIR2-like domain-containing protein | 著者 | Zheng, J, Yang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Structural insights into autoinhibition and activation of defense-associated sirtuin protein. Int.J.Biol.Macromol., 277, 2024
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8VI3
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![BU of 8vi3 by Molmil](/molmil-images/mine/8vi3) | TehA from Haemophilus influenzae purified in GDN | 分子名称: | Tellurite resistance protein TehA homolog | 著者 | Catalano, C, Senko, S, Tran, N.L, Lucier, K.W, Farwell, A.C, Silva, M.S, Dip, P.V, Poweleit, N, Scapin, G. | 登録日 | 2024-01-03 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy. Int J Mol Sci, 25, 2024
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9EOJ
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9F3Z
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8XE0
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![BU of 8xe0 by Molmil](/molmil-images/mine/8xe0) | O-methyltransferase from Lycoris longituba M52W variant complexed with Mg, SAH, and 3,4-dihydroxybenzaldehyde | 分子名称: | MAGNESIUM ION, Protocatechuic aldehyde, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Saw, Y.Y.H, Nakashima, Y, Morita, H. | 登録日 | 2023-12-11 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases Acs Catalysis, 2024
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8WKO
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8X87
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8VR2
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![BU of 8vr2 by Molmil](/molmil-images/mine/8vr2) | Crystal structure of the Pcryo_0617 oxidoreductase/decarboxylase from Psychrobacter cryohalolentis K5 in the presence of NAD and UDP | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, NAD-dependent epimerase/dehydratase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Bockhaus, N.J, Thoden, J.B, Holden, H.M. | 登録日 | 2024-01-20 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Biochemical Investigation of the Enzymes Required for the Production of 2,3,4-triacetoamido-2,3,4-trideoxy-l-arabinose in Psychrobacter cryohalolentis K5 To Be Published
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8VI2
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![BU of 8vi2 by Molmil](/molmil-images/mine/8vi2) | TehA from Haemophilus influenzae purified in DDM | 分子名称: | Tellurite resistance protein TehA homolog | 著者 | Catalano, C, Senko, S, Tran, N.L, Lucier, K.W, Farwell, A.C, Silva, M.S, Dip, P.V, Poweleit, N, Scapin, G. | 登録日 | 2024-01-03 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy. Int J Mol Sci, 25, 2024
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9FXP
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![BU of 9fxp by Molmil](/molmil-images/mine/9fxp) | Crystal structure of BRD4 BD1 with DI00626383. | 分子名称: | 4-methoxy-1,2-benzoxazol-3-amine, Bromodomain-containing protein 4 | 著者 | Bader, G, Reinert, D. | 登録日 | 2024-07-02 | 公開日 | 2024-08-07 | 最終更新日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Probing Protein-Ligand Methyl-pi Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups. J.Med.Chem., 67, 2024
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8WCQ
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![BU of 8wcq by Molmil](/molmil-images/mine/8wcq) | Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in intermediate state | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHLORIDE ION, Proton-gated ion channel | 著者 | Bharambe, N, Li, Z, Basak, S. | 登録日 | 2023-09-13 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment. Nat Commun, 15, 2024
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9EU6
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![BU of 9eu6 by Molmil](/molmil-images/mine/9eu6) | The FK1 domain of FKBP51 in complex with SAFit-analog 23j | 分子名称: | (1,5-dimethylpyrazol-4-yl)methyl (2~{S})-1-[(2~{S})-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | 著者 | Meyners, C, Buffa, V, Hausch, F. | 登録日 | 2024-03-27 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
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9AUJ
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![BU of 9auj by Molmil](/molmil-images/mine/9auj) | Structure of SARS-CoV-2 Mpro mutant (S144A) in complex with Nirmatrelvir (PF-07321332) | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | 登録日 | 2024-02-29 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.486 Å) | 主引用文献 | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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8Z3S
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![BU of 8z3s by Molmil](/molmil-images/mine/8z3s) | Activation mechanism and novel binding site of the BKCa channel activator CTIBD | 分子名称: | 4-[4-(4-chlorophenyl)-3-(trifluoromethyl)-1,2-oxazol-5-yl]benzene-1,3-diol, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Lee, N, Kim, S, Jo, H, Lee, N.Y, Jin, M.S, Park, C.S. | 登録日 | 2024-04-16 | 公開日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Activation mechanism and novel binding site of the BKCa channel activator CTIBD To Be Published
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8X2U
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![BU of 8x2u by Molmil](/molmil-images/mine/8x2u) | Radial spoke head-neck dimer | 分子名称: | DPY30 domain containing 2, DnaJ homolog subfamily B member 13, Nucleoside diphosphate kinase homolog 5, ... | 著者 | Meng, X, Cong, Y. | 登録日 | 2023-11-10 | 公開日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia. Nat Commun, 15, 2024
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8WY1
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![BU of 8wy1 by Molmil](/molmil-images/mine/8wy1) | The structure of cyclization domain in cyclic beta-1,2-glucan synthase from Thermoanaerobacter italicus | 分子名称: | Glycosyltransferase 36 | 著者 | Tanaka, N, Saito, R, Kobayashi, K, Nakai, H, Kamo, S, Kuramochi, K, Taguchi, H, Nakajima, M, Masaike, T. | 登録日 | 2023-10-30 | 公開日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Functional and structural analysis of a cyclization domain in a cyclic beta-1,2-glucan synthase. Appl.Microbiol.Biotechnol., 108, 2024
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8X3E
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![BU of 8x3e by Molmil](/molmil-images/mine/8x3e) | CYP725A4-Taxa-4,11-diene complex | 分子名称: | (1~{R},3~{R},8~{R})-4,8,12,15,15-pentamethyltricyclo[9.3.1.0^{3,8}]pentadeca-4,11-diene, PROTOPORPHYRIN IX CONTAINING FE, Taxadiene 5-alpha hydroxylase | 著者 | Chang, Z, Wang, Q. | 登録日 | 2023-11-13 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Unraveling the Catalytic Mechanism of Taxadiene-5alpha-hydroxylase from Crystallography and Computational Analyses. Acs Catalysis, 14, 2024
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8WNG
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![BU of 8wng by Molmil](/molmil-images/mine/8wng) | Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Ile | 分子名称: | ACETATE ION, GLYCEROL, ISOLEUCINE, ... | 著者 | Guo, Y, Li, S, Zhang, T. | 登録日 | 2023-10-05 | 公開日 | 2024-02-14 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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9BAZ
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![BU of 9baz by Molmil](/molmil-images/mine/9baz) | CryoEM structure of DIM2-HP1 complex | 分子名称: | DNA (cytosine-5-)-methyltransferase, Heterochromatin protein one, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Song, J, Shao, Z. | 登録日 | 2024-04-05 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | CryoEM structure of DIM2-HP1 complex To Be Published
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