8YSX
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![BU of 8ysx by Molmil](/molmil-images/mine/8ysx) | canine immunoproteasome 20S subunit in complex with compound 2 | 分子名称: | Proteasome subunit alpha type, Proteasome subunit beta, Proteasome subunit beta type-8, ... | 著者 | Kashima, A, Arai, Y. | 登録日 | 2024-03-24 | 公開日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Optimization of alpha-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 ( beta 5i)/LMP2 ( beta 1i) dual inhibitor. Bioorg.Med.Chem., 109, 2024
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8VJR
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8XI9
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![BU of 8xi9 by Molmil](/molmil-images/mine/8xi9) | Crystal structure of FRB-FKBP fusion protein in complex with rapamycin | 分子名称: | FRB-FKBP fusion protein, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | 著者 | Inobe, T, Sakaguchi, R, Obita, T, Mukaiyama, A, Yokoyama, T, Mizuguchi, M, Akiyama, S. | 登録日 | 2023-12-19 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural insights into rapamycin-induced oligomerization of a FRB-FKBP fusion protein. Febs Lett., 2024
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8Y0W
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![BU of 8y0w by Molmil](/molmil-images/mine/8y0w) | dormant ribosome with eIF5A, eEF2 and SERBP1 | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Du, M, Zeng, F. | 登録日 | 2024-01-23 | 公開日 | 2024-02-07 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes. Front Mol Biosci, 11, 2024
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9BFY
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![BU of 9bfy by Molmil](/molmil-images/mine/9bfy) | Tri-complex of Compound-12, KRAS G12C, and CypA | 分子名称: | (3R)-N-[(2S)-1-{[(1M,8R,10R,14S,21M)-22-ethyl-4-hydroxy-21-{2-[(1R)-1-methoxyethyl]pyridin-3-yl}-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1~2,6~.1~10,14~.0~23,27~]nonacosa-1(25),2(29),3,5,20,23,26-heptaen-8-yl]amino}-3-methyl-1-oxobutan-2-yl]-N-methyl-1-propanoylpyrrolidine-3-carboxamide (non-preferred name), CHLORIDE ION, GTPase KRas, ... | 著者 | Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. | 登録日 | 2024-04-18 | 公開日 | 2024-06-12 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Tri-complex of Compound-12, KRAS G12C, and CypA To be published
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9CK3
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![BU of 9ck3 by Molmil](/molmil-images/mine/9ck3) | Cryo-EM structure of in-vitro alpha-synuclein fibril | 分子名称: | Alpha-synuclein | 著者 | Sanchez, J.C, Borcik, C.G, Tonelli, M, Sibert, B, Rienstra, C.M, Wright, E.R. | 登録日 | 2024-07-08 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.04 Å) | 主引用文献 | Multimodal High-Resolution Structure Determination Of Alpha-Synuclein Fibrils To Be Published
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8WBK
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![BU of 8wbk by Molmil](/molmil-images/mine/8wbk) | Crystal structure of cis-Epoxysuccinate Hydrolases RhCESH[L] | 分子名称: | Epoxide hydrolase, SULFATE ION | 著者 | Dong, S, Xuan, J.S, Feng, Y.G, Cui, Q. | 登録日 | 2023-09-10 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem., 300, 2024
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8W3W
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![BU of 8w3w by Molmil](/molmil-images/mine/8w3w) | Crystal structure of IRAK4 in complex with compound 4 | 分子名称: | 7-methoxy-1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}isoquinoline-6-carboxamide, Interleukin-1 receptor-associated kinase 4 | 著者 | Han, S, Knafels, J.D. | 登録日 | 2024-02-22 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.976 Å) | 主引用文献 | In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833). Acs Med.Chem.Lett., 15, 2024
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9BG1
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![BU of 9bg1 by Molmil](/molmil-images/mine/9bg1) | Tri-complex of Compound-3, KRAS G12V, and CypA | 分子名称: | (2R)-N-[(1P,7S,9S,13R,20M)-21-ethyl-20-{2-[(1S)-1-methoxyethyl]pyridin-3-yl}-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-methyl-2-(N-methylacetamido)butanamide (non-preferred name), GTPase KRas, MAGNESIUM ION, ... | 著者 | Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. | 登録日 | 2024-04-18 | 公開日 | 2024-06-12 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Tri-complex of Compound-3, KRAS G12V, and CypA To be published
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8WZP
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![BU of 8wzp by Molmil](/molmil-images/mine/8wzp) | Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with CCF0058981 | 分子名称: | 2-(benzotriazol-1-yl)-~{N}-[(3-chlorophenyl)methyl]-~{N}-[4-(1~{H}-imidazol-5-yl)phenyl]ethanamide, 3C-like proteinase nsp5 | 著者 | Jiang, H.H, Zou, X.F, Zhou, X.L, Zhang, J, Li, J. | 登録日 | 2023-11-02 | 公開日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Crystal structure of SARS-CoV-2 main protease (M pro ) mutants in complex with the non-covalent inhibitor CCF0058981. Biochem.Biophys.Res.Commun., 692, 2024
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8VCN
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![BU of 8vcn by Molmil](/molmil-images/mine/8vcn) | GluER mutant - W66F F269Y Q293T F68Y T36E P263L | 分子名称: | ACETATE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | 著者 | Jeffrey, P.D, Sorigue, D.R, Liu, Y, Hyster, T.K. | 登録日 | 2023-12-14 | 公開日 | 2024-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Asymmetric Synthesis of alpha-Chloroamides via Photoenzymatic Hydroalkylation of Olefins. J.Am.Chem.Soc., 146, 2024
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8X2R
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![BU of 8x2r by Molmil](/molmil-images/mine/8x2r) | The Crystal Structure of HSP 90-alpha from Biortus. | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Heat shock protein HSP 90-alpha | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Lu, Y. | 登録日 | 2023-11-10 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | The Crystal Structure of HSP 90-alpha from Biortus. To Be Published
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9EUE
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![BU of 9eue by Molmil](/molmil-images/mine/9eue) | The FK1 domain of FKBP51 in complex with SAFit-analog 23a | 分子名称: | (1-methylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | 著者 | Meyners, C, Buffa, V, Hausch, F. | 登録日 | 2024-03-27 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
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8VI4
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![BU of 8vi4 by Molmil](/molmil-images/mine/8vi4) | TehA from Haemophilus influenzae purified in LMNG | 分子名称: | Tellurite resistance protein TehA homolog | 著者 | Catalano, C, Senko, S, Tran, N.L, Lucier, K.W, Farwell, A.C, Silva, M.S, Dip, P.V, Poweleit, N, Scapin, G. | 登録日 | 2024-01-03 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy. Int J Mol Sci, 25, 2024
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9AT6
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![BU of 9at6 by Molmil](/molmil-images/mine/9at6) | Crystal structure of SARS-CoV-2 3CL protease in complex with a methylbicyclo[2.2.1]heptene 2-pyrrolidone inhibitor | 分子名称: | (1R,2S)-2-{[N-({[(2S)-1-{[(1R,2S,4R)-bicyclo[2.2.1]hept-5-en-2-yl]methyl}-5-oxopyrrolidin-2-yl]methoxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-{[N-({[(2S)-1-{[(1R,2S,4R)-bicyclo[2.2.1]hept-5-en-2-yl]methyl}-5-oxopyrrolidin-2-yl]methoxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, ... | 著者 | Lovell, S, Cooper, A, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | 登録日 | 2024-02-26 | 公開日 | 2024-07-10 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies. J.Med.Chem., 67, 2024
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9F1T
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8WFI
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8X1W
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![BU of 8x1w by Molmil](/molmil-images/mine/8x1w) | CYP725A4 apo structure | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Taxadiene 5-alpha hydroxylase | 著者 | Chang, Z, Wang, Q. | 登録日 | 2023-11-09 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Unraveling the Catalytic Mechanism of Taxadiene-5alpha-hydroxylase from Crystallography and Computational Analyses. Acs Catalysis, 14, 2024
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8VGC
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![BU of 8vgc by Molmil](/molmil-images/mine/8vgc) | Complex of ExbD with D-box peptide: Orthorhombic form | 分子名称: | Biopolymer transport protein ExbD, GLN-PRO-ILE-SER-VAL-THR-MET-VAL-THR-PRO | 著者 | Loll, P.J. | 登録日 | 2023-12-27 | 公開日 | 2024-02-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Discovery and structural characterization of the D-box, a conserved TonB motif that couples an inner-membrane motor to outer-membrane transport. J.Biol.Chem., 300, 2024
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8VTK
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8X35
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![BU of 8x35 by Molmil](/molmil-images/mine/8x35) | Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP, IPP, and magnesium ion (form A) | 分子名称: | 1,2-ETHANEDIOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Imaizumi, R, Matsuura, H, Yanai, T, Takeshita, K, Misawa, S, Yamaguchi, H, Sakai, N, Miyagi-Inoue, Y, Suenaga-Hiromori, M, Kataoka, K, Nakayama, T, Yamamoto, M, Takahashi, S, Yamashita, S. | 登録日 | 2023-11-12 | 公開日 | 2024-02-07 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato. Chembiochem, 25, 2024
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9ATJ
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![BU of 9atj by Molmil](/molmil-images/mine/9atj) | Crystal structure of MERS 3CL protease in complex with a m-chlorobenzyl 2-pyrrolidone inhibitor | 分子名称: | (1R,2S)-2-({N-[({(2S)-1-[(3-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-({N-[({(2S)-1-[(3-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, ... | 著者 | Liu, L, Lovell, S, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | 登録日 | 2024-02-26 | 公開日 | 2024-07-10 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies. J.Med.Chem., 67, 2024
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8X2S
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![BU of 8x2s by Molmil](/molmil-images/mine/8x2s) | The Crystal Structure of BPGM from Biortus | 分子名称: | 1,2-ETHANEDIOL, Bisphosphoglycerate mutase | 著者 | Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. | 登録日 | 2023-11-10 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Crystal Structure of BPGM from Biortus To Be Published
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8Z1L
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![BU of 8z1l by Molmil](/molmil-images/mine/8z1l) | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant atomoxetine in an outward-open state at resolution of 3.4 angstrom. | 分子名称: | (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine, CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2024-04-11 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 2024
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8XXQ
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