9FX6
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![BU of 9fx6 by Molmil](/molmil-images/mine/9fx6) | Crystal structure of Cryo2RT SARS-CoV-2 main protease at 100K | 分子名称: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... | 著者 | Huang, C.Y, Aumonier, S, Mac Sweeney, A, Olieric, V, Wang, M. | 登録日 | 2024-07-01 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.227 Å) | 主引用文献 | Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals. Acta Crystallogr D Struct Biol, 80, 2024
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8VG7
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![BU of 8vg7 by Molmil](/molmil-images/mine/8vg7) | Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) | 分子名称: | D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-23 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8XVC
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8VEQ
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![BU of 8veq by Molmil](/molmil-images/mine/8veq) | Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 in complex with azlocillin | 分子名称: | (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxo-1-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}ethyl]-1,3-thiazolidine-4-carboxylic acid, Probable peptidoglycan D,D-transpeptidase PenA | 著者 | Stratton, C, Bala, S, Davies, C. | 登録日 | 2023-12-20 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041. Acs Infect Dis., 10, 2024
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9AXG
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9EYR
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![BU of 9eyr by Molmil](/molmil-images/mine/9eyr) | VDR complex with gemini analog UG-480 | 分子名称: | (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(1~{R})-5-methyl-1-[(1~{S},2~{S})-2-(3-methyl-3-oxidanyl-butyl)cyclopropyl]-5-oxidanyl-hexyl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | 著者 | Rochel, N. | 登録日 | 2024-04-09 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of New Type of Gemini Analogues with a Cyclopropane Moiety in Their Side Chain. J.Med.Chem., 67, 2024
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8YKU
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8VRK
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![BU of 8vrk by Molmil](/molmil-images/mine/8vrk) | Rigid body fitted model for refined density map of gamma tubulin ring complex capped microtubule | 分子名称: | Actin, cytoplasmic 1, Gamma-tubulin complex component 3, ... | 著者 | Aher, A, Urnavicius, L, Kapoor, T.M. | 登録日 | 2024-01-22 | 公開日 | 2024-03-27 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | 主引用文献 | Structure of the gamma-tubulin ring complex-capped microtubule. Nat.Struct.Mol.Biol., 31, 2024
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8XT3
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![BU of 8xt3 by Molmil](/molmil-images/mine/8xt3) | Cryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline | 分子名称: | 16s rRNA, 39S ribosomal protein L22, mitochondrial, ... | 著者 | Li, X, Wang, M, Cheng, J. | 登録日 | 2024-01-10 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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9EM2
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8WBS
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![BU of 8wbs by Molmil](/molmil-images/mine/8wbs) | Crystal structure of cis-Epoxysuccinate Hydrolases KlCESH[L]-D48N complexed with sulfate ions | 分子名称: | (S)-2-haloacid dehalogenase, CALCIUM ION, SULFATE ION | 著者 | Dong, S, Xuan, J.S, Feng, Y.G, Cui, Q. | 登録日 | 2023-09-10 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem., 300, 2024
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8XIA
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8WU4
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![BU of 8wu4 by Molmil](/molmil-images/mine/8wu4) | Cryo-EM structure of native H. thermoluteolus TH-1 GroEL | 分子名称: | Chaperonin GroEL | 著者 | Liao, Z, Gopalasingam, C.C, Kameya, M, Gerle, C, Shigematsu, H, Ishii, M, Arakawa, T, Fushinobu, S. | 登録日 | 2023-10-20 | 公開日 | 2024-03-27 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into thermophilic chaperonin complexes. Structure, 32, 2024
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8Y7M
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![BU of 8y7m by Molmil](/molmil-images/mine/8y7m) | FluPol-NS2 complex (local refinement) | 分子名称: | Nuclear export protein, Polymerase acidic protein, Polymerase basic protein 2, ... | 著者 | Peng, Q, Sun, J.Q. | 登録日 | 2024-02-04 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | NS2 stabilizes polymerase hexamer to regulate transcription-replication switch of influenza A virus To Be Published
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8VBU
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![BU of 8vbu by Molmil](/molmil-images/mine/8vbu) | Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Oxacillin) inhibited form | 分子名称: | (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, Penicillin-binding protein 1 | 著者 | Bon, C.G, Lee, J, Caveney, N.A, Strynadka, N.C.J. | 登録日 | 2023-12-12 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216, 2024
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8VLX
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9B8D
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![BU of 9b8d by Molmil](/molmil-images/mine/9b8d) | Structure of Legionella pneumophila Ceg10 | 分子名称: | 1,2-ETHANEDIOL, Ceg10, PHOSPHATE ION | 著者 | Tomchick, D.R, Heisler, D.B, Alto, N.M. | 登録日 | 2024-03-29 | 公開日 | 2024-04-10 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery. Plos Pathog., 20, 2024
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8YFK
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8VH7
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![BU of 8vh7 by Molmil](/molmil-images/mine/8vh7) | Crystal structure of heparosan synthase 2 from Pasteurella multocida at 1.98 A | 分子名称: | 1,2-ETHANEDIOL, Heparosan synthase B, MANGANESE (II) ION, ... | 著者 | Pedersen, L.C, Liu, J, Stancanelli, E, Krahn, J.M. | 登録日 | 2023-12-31 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.982 Å) | 主引用文献 | Structural and Functional Analysis of Heparosan Synthase 2 from Pasteurella multocida to Improve the Synthesis of Heparin Acs Catalysis, 14, 2024
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8VHM
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![BU of 8vhm by Molmil](/molmil-images/mine/8vhm) | Structure of DHODH in Complex with Fragment 2 | 分子名称: | ACETATE ION, CHLORIDE ION, Dihydroorotate dehydrogenase (quinone), ... | 著者 | Shaffer, P.L. | 登録日 | 2024-01-02 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors. Acs Med.Chem.Lett., 15, 2024
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8VG5
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![BU of 8vg5 by Molmil](/molmil-images/mine/8vg5) | Crystal Structure of V113N Variant of D-Dopachrome Tautomerase (D-DT) Bound with 4CPPC | 分子名称: | 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, CITRIC ACID, D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-22 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8ZH4
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![BU of 8zh4 by Molmil](/molmil-images/mine/8zh4) | HIV-1 integrase core domain in complex with compound 5 | 分子名称: | (2~{S})-2-(4',5-dimethylspiro[1,2-dihydroindene-3,1'-cyclohexane]-4-yl)-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, SULFATE ION, ... | 著者 | Furuzono, T, Orita, T, Nomura, A, Adachi, T. | 登録日 | 2024-05-10 | 公開日 | 2024-07-10 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. Bioorg.Med.Chem.Lett., 110, 2024
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9EX0
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![BU of 9ex0 by Molmil](/molmil-images/mine/9ex0) | X-ray structure of a polyoxidovanadate/lysozyme adduct obtained when the protein is treated with [VIVO(acac)2] in 1.1 M NaCl, 0.1 M sodium acetate at pH 4.0 (Structure A) | 分子名称: | CHLORIDE ION, Lysozyme C, Polyoxidovanadate complex, ... | 著者 | Tito, G, Merlino, A, Ferraro, G. | 登録日 | 2024-04-05 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Non-Covalent and Covalent Binding of New Mixed-Valence Cage-like Polyoxidovanadate Clusters to Lysozyme. Angew.Chem.Int.Ed.Engl., 63, 2024
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8WBO
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![BU of 8wbo by Molmil](/molmil-images/mine/8wbo) | Crystal structure of cis-Epoxysuccinate Hydrolases RhCESH[L] mutant D18N complexed with sulfate ions | 分子名称: | Epoxide hydrolase, SULFATE ION | 著者 | Dong, S, Xuan, J.S, Feng, Y.G, Cui, Q. | 登録日 | 2023-09-10 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem., 300, 2024
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8XN8
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![BU of 8xn8 by Molmil](/molmil-images/mine/8xn8) | The Crystal Structure of SRC from Biortus. | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. | 登録日 | 2023-12-29 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Crystal Structure of SRC from Biortus. To Be Published
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