PDB: 2201 件ウェブページステータス検索Chemie searchBIRD

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5RKD	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z2168282707 分子名称: (6S)-1-methyl-4,5,6,7-tetrahydro-1H-benzotriazole-6-carboxylic acid, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.237 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
8WYP	High Resolution Crystal Structure of Brd4 BD-1 in Complex with a Novel Inhibitor Precursor 分子名称: 3-bromanylimidazo[1,2-a]pyridin-6-amine, Bromodomain-containing protein 4 著者 Liu, B, Ma, X. 登録日 2023-10-31 公開日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 High resolution crystal structure of BRD4-BD1 in complex with a novel inhibitor precursor. Biochem.Biophys.Res.Commun., 690, 2024
5RJI	PanDDA analysis group deposition of ground-state model of PHIP 分子名称: PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
5RKS	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z1696844792 分子名称: 1-(diphenylmethyl)azetidin-3-ol, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
5RK0	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z30932204 分子名称: N-[(4-sulfamoylphenyl)methyl]acetamide, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
5RKX	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z1324080698 分子名称: 3-fluoro-5-methylbenzene-1-sulfonamide, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
5RKC	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z234898257 分子名称: N-methyl-1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
5S8K	XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N01225c (space group C2) 分子名称: 3,4-dimethyl-1,2-oxazol-5-amine, PH-interacting protein 著者 Krojer, T, Talon, R, Fairhead, M, Szykowska, A, Burgess-Brown, N.A, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F. 登録日 2020-12-17 公開日 2021-01-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 XChem group deposition To Be Published
5S8E	XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00531b (space group C2) 分子名称: 2,3-dihydro-1,4-benzodioxine-5-carboxamide, PH-interacting protein 著者 Krojer, T, Talon, R, Fairhead, M, Szykowska, A, Burgess-Brown, N.A, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F. 登録日 2020-12-17 公開日 2021-01-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 XChem group deposition To Be Published
5S8Y	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative 分子名称: N-(cyclopropylmethyl)-4-(furan-2-carbonyl)piperazine-1-carboxamide, PH-interacting protein 著者 Grosjean, H, Aimon, A, Hassel-Hart , S, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Biggin, P.C, Spencer, J, von Delft, F. 登録日 2021-01-22 公開日 2021-02-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Crystal Structures of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group C2 soaked with crude reaction mixtures To Be Published
4J3I	X-ray crystal structure of bromodomain complex to 1.24 A resolution 分子名称: 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 4, ... 著者 Stein, A.J, White, A, Suto, R.K. 登録日 2013-02-05 公開日 2014-01-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. Plos One, 8, 2013
7WX2	CBP-BrD complexed with NEO2734 分子名称: 1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethyloxy)ethyl]benzimidazol-5-yl]pyridin-2-one, CREB-binding protein 著者 Zeng, L, Lei, J.D. 登録日 2022-02-14 公開日 2022-06-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer. Oncogene, 41, 2022
5RK6	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z198194394 分子名称: 4-(4-fluorophenyl)piperazine-1-carboxamide, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.241 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
5RKT	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z1266933824 分子名称: (1H-pyrazol-4-yl)(pyrrolidin-1-yl)methanone, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.241 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
5RJP	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with NCL-00024672 分子名称: 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.242 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
5RKW	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z27678561 分子名称: N-(6-methoxy-1,3-benzothiazol-2-yl)cyclopropanecarboxamide, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.242 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
5RK5	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z57478994 分子名称: 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.243 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
7B82	BAZ2A bromodomain in complex with triazole compound MS04-TN03 分子名称: (2~{S})-1-[4-[[(~{E})-~{N},~{N}'-dimethylcarbamimidoyl]amino]phenyl]-~{N}-[[2-(3-methyl-1,2,3-triazol-4-yl)-1~{H}-benzimidazol-5-yl]methyl]pyrrolidine-2-carboxamide, Bromodomain adjacent to zinc finger domain protein 2A 著者 Dalle Vedove, A, Cazzanelli, G, Sedykh, M, Caflisch, A, Lolli, G. 登録日 2020-12-12 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing. Acs Med.Chem.Lett., 13, 2022
7FV7	PanDDA analysis group deposition -- PHIP in complex with Z1929967066 分子名称: (3R)-4-(furan-2-carbonyl)-3-methyl-N-(propan-2-yl)piperazine-1-carboxamide, PH-interacting protein 著者 Grosjean, H, Tomlinson, C, Bradshaw, W.J, Koekemoer, L, Krojer, T, Fearon, D, Biggin, P.C, von Delft, F. 登録日 2023-03-09 公開日 2023-03-29 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 PanDDA analysis group deposition To Be Published
5MWZ	Crystal structure of the human BRPF1 bromodomain in complex with BZ073 分子名称: Peregrin, ~{N}-[1,4-diethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-2-(4-methylpiperazin-1-yl)ethanamide 著者 Zhu, J, Caflisch, A. 登録日 2017-01-20 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155, 2018
6YQP	Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW22 分子名称: (~{E})-3-[4-[[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6 ),4,7,10,12-pentaen-9-yl]ethanoylamino]methyl]phenyl]-~{N}-oxidanyl-prop-2-enamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 著者 Joerger, A.C, Balourdas, D.I, Weiser, T, Chatterjee, D, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-04-17 公開日 2020-05-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma. Int.J.Cancer, 147, 2020
5RJY	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z383325512 分子名称: N-[(1H-pyrazol-4-yl)methyl]acetamide, PH-interacting protein 著者 Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. 登録日 2020-06-02 公開日 2020-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 PanDDA analysis group deposition of ground-state model To Be Published
7ZFS	BRD4 in complex with FragLite32 分子名称: 1,2-ETHANEDIOL, 4-bromanyl-1,2-dimethoxy-benzene, Bromodomain-containing protein 4, ... 著者 Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. 登録日 2022-04-01 公開日 2022-11-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
5R4G	PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF in complex with FMOPL000621a 分子名称: 4-(1,2,3-thiadiazol-4-yl)phenyl ethylcarbamate, DIMETHYL SULFOXIDE, Nucleosome-remodeling factor subunit BPTF 著者 Talon, R, Krojer, T, Fairhead, M, Sethi, R, Bradley, A.R, Aimon, A, Collins, P, Brandao-Neto, J, Douangamath, A, Wright, N, MacLean, E, Renjie, Z, Dias, A, Brennan, P.E, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. 登録日 2020-02-24 公開日 2020-04-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 PanDDA analysis group deposition To Be Published
5S8C	XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00322e (space group C2) 分子名称: (1-methylbenzotriazol-5-yl)methanol, PH-interacting protein 著者 Krojer, T, Talon, R, Fairhead, M, Szykowska, A, Burgess-Brown, N.A, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F. 登録日 2020-12-17 公開日 2021-01-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 XChem group deposition To Be Published

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