PDB: 46200 件ウェブページステータス検索Chemie searchBIRD

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6AZH	Clostridium perfringens putative fatty acid metabolism regulator 分子名称: TetR family transcriptional regulator 著者 William, W.G, Redinbo, M.R. 登録日 2017-09-11 公開日 2017-12-20 最終更新日 2018-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural basis for the regulation of beta-glucuronidase expression by human gut Enterobacteriaceae. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8SXM	NMR structure of the ZNF750 zinc finger domain, Z* 分子名称: ZINC ION, Zinc finger protein 750 著者 Rua, A.J, Alexandrescu, A.T. 登録日 2023-05-22 公開日 2023-08-23 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750. J Struct Biol X, 8, 2023
5IWJ	LAmbda-[Ru(TAP)2(dppz)]2+ bound to d(CCGGGCCCGG 分子名称: BARIUM ION, DNA (5'-D(*CP*CP*GP*GP*GP*CP*CP*CP*GP*G)-3'), Ru(tap)2(dppz) complex 著者 Souter, J.E, Hall, J.P, Cardin, C.J. 登録日 2016-03-22 公開日 2017-04-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 The binding specificity of RuTAP2dppz To Be Published
8OZC	cryoEM structure of SPARTA complex heterodimer apo 分子名称: Piwi domain-containing protein, TIR domain-containing protein 著者 Ekundayo, B, Ni, D.C, Lu, X.H, Stahlberg, H. 登録日 2023-05-09 公開日 2023-08-16 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Activation mechanism of a short argonaute-TIR prokaryotic immune system. Sci Adv, 9, 2023
1MYL	SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY 分子名称: ARC REPRESSOR 著者 Schildbach, J.F, Waldburger, C.D, Sauer, R.T. 登録日 1994-10-06 公開日 1995-01-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Are buried salt bridges important for protein stability and conformational specificity? Nat.Struct.Biol., 2, 1995
7S1O	Structure of human POT1C 分子名称: Protection of telomeres protein 1, ZINC ION 著者 Aramburu, T, Skordalakes, E. 登録日 2021-09-02 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance. Comput Struct Biotechnol J, 20, 2022
7S1T	Structure of the human POT1-TPP1 complex 分子名称: Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION 著者 Aramburu, T, Skordalakes, E. 登録日 2021-09-02 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance. Comput Struct Biotechnol J, 20, 2022
7S1U	Structure of human POT1C 分子名称: Protection of telomeres protein 1, ZINC ION 著者 Aramburu, T, Skordalakes, E. 登録日 2021-09-02 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance. Comput Struct Biotechnol J, 20, 2022
7W82	Crystal structure of maize RDR2 分子名称: RNA-dependent RNA polymerase 著者 Du, X, Yang, Z, Du, J. 登録日 2021-12-07 公開日 2022-06-08 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell, 34, 2022
7W88	CryoEM structure of open form ZmRDR2 at 3.5 Angstroms resolution 分子名称: RNA-dependent RNA polymerase 著者 Du, X, Yang, Z, Du, J. 登録日 2021-12-07 公開日 2022-06-08 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell, 34, 2022
7W84	CryoEM structure of apo form ZmRDR2 at 3.4 Angstroms resolution 分子名称: RNA-dependent RNA polymerase 著者 Du, X, Yang, Z, Du, J. 登録日 2021-12-07 公開日 2022-06-08 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell, 34, 2022
1HHW	Solution structure of LNA1:RNA hybrid 分子名称: 5- D(*CP*TP*GP*AP*+TLNP*AP*TP*GP*C) -3, 5- R(*GP*CP*AP*UP*AP*UP*CP*AP*G) -3 著者 Petersen, M, Bondensgaard, K, Wengel, J, Jacobsen, J.P. 登録日 2000-12-29 公開日 2002-05-30 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Locked Nucleic Acid (Lna) Recognition of RNA: NMR Solution Structures of Lna:RNA Hybrids J.Am.Chem.Soc., 124, 2002
5LBA	Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening. 分子名称: 1-cyclohexyl-3-[[(2~{R})-oxolan-2-yl]methyl]urea, ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase Q5, ... 著者 Newman, J.A, Aitkenhead, H, Talon, R, Savitsky, P, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O, Structural Genomics Consortium (SGC) 登録日 2016-06-15 公開日 2016-07-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human RECQL5 helicase in complex with 3D fragment (1-cyclohexyl-3-(oxolan-2-ylmethyl)urea) To be published
7R2K	elongated Cascade complex from type I-A CRISPR-Cas system 分子名称: CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... 著者 Hu, C, Ni, D, Nam, K.H, Terns, M, Stahlberg, H, Ke, A. 登録日 2022-02-04 公開日 2023-08-16 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural snapshots for an atypic type I CRISPR-Cas system To Be Published
1FV5	SOLUTION STRUCTURE OF THE FIRST ZINC FINGER FROM THE DROSOPHILA U-SHAPED TRANSCRIPTION FACTOR 分子名称: FIRST ZINC FINGER OF U-SHAPED, ZINC ION 著者 Liew, C.K, Kowalski, K, Fox, A.H, Newton, A, Sharpe, B.K, Crossley, M, Mackay, J.P. 登録日 2000-09-18 公開日 2000-10-04 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions. Structure Fold.Des., 8, 2000
8PFL	Crystal structure of WRN helicase domain in complex with 3 分子名称: 2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-7-oxidanylidene-6-[4-(3-oxidanylpyridin-2-yl)carbonylpiperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]-~{N}-[2-methyl-4-(trifluoromethyl)phenyl]ethanamide, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION 著者 Scheufler, C, Meyer, M, Moebitz, H. 登録日 2023-06-16 公開日 2024-04-24 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature, 629, 2024
8PFO	Crystal structure of WRN helicase domain in complex with HRO761 分子名称: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION, ~{N}-[2-chloranyl-4-(trifluoromethyl)phenyl]-2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-6-[4-(6-methyl-5-oxidanyl-pyrimidin-4-yl)carbonylpiperazin-1-yl]-7-oxidanylidene-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]ethanamide 著者 Scheufler, C, Meyer, M, Moebitz, H. 登録日 2023-06-16 公開日 2024-04-24 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature, 629, 2024
8PFP	Crystal structure of WRN helicase domain in complex with ATPgammaS 分子名称: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ZINC ION 著者 Scheufler, C, Villard, F. 登録日 2023-06-16 公開日 2024-04-24 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature, 629, 2024
8TU6	CryoEM structure of PI3Kalpha 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Valverde, R, Shi, H, Holliday, M. 登録日 2023-08-15 公開日 2023-11-15 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
1NSK	THE CRYSTAL STRUCTURE OF A HUMAN NUCLEOSIDE DIPHOSPHATE KINASE, NM23-H2 分子名称: NUCLEOSIDE DIPHOSPHATE KINASE 著者 Williams, R.L, Perisic, O. 登録日 1995-07-04 公開日 1995-10-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The crystal structure of a human nucleoside diphosphate kinase, NM23-H2. J.Mol.Biol., 251, 1995
1KCI	Crystal Structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide Bound to d(CGTACG)2 分子名称: 5'-D(*CP*GP*TP*AP*CP*G)-3', 9-AMINO-N-[2-(4-MORPHOLINYL)ETHYL]-4-ACRIDINECARBOXAMIDE 著者 Adams, A, Guss, J.M, Denny, W.A, Wakelin, L.P.G. 登録日 2001-11-08 公開日 2002-02-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons. Nucleic Acids Res., 30, 2002
6D0L	Structure of human TIRR 分子名称: Tudor-interacting repair regulator protein 著者 Cui, G, Botuyan, M.V, Mer, G. 登録日 2018-04-10 公開日 2018-06-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat. Struct. Mol. Biol., 25, 2018
7TRC	Human telomerase H/ACA RNP at 3.3 Angstrom 分子名称: H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... 著者 Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. 登録日 2022-01-28 公開日 2022-04-20 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of active human telomerase with telomere shelterin protein TPP1. Nature, 604, 2022
1UPG	Crystal structure of the quorum-sensing protein TraM from Agrobacterium tumefaciens 分子名称: TRANSCRIPTIONAL REPRESSOR TRAM 著者 Vannini, A, Di Marco, S. 登録日 2003-09-30 公開日 2004-05-25 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of the Quorum-Sensing Protein Tram and its Interaction with the Transcriptional Regulator Trar J.Biol.Chem., 279, 2004
1GUW	STRUCTURE OF THE CHROMODOMAIN FROM MOUSE HP1beta IN COMPLEX WITH THE LYSINE 9-METHYL HISTONE H3 N-TERMINAL PEPTIDE, NMR, 25 STRUCTURES 分子名称: CHROMOBOX PROTEIN HOMOLOG 1, HISTONE H3.1 著者 Nielsen, P.R, Nietlispach, D, Mott, H.R, Callaghan, J.M, Bannister, A, Kouzarides, T, Murzin, A.G, Murzina, N.V, Laue, E.D. 登録日 2002-02-01 公開日 2002-03-12 最終更新日 2018-01-17 実験手法 SOLUTION NMR 主引用文献 Structure of the Hp1 Chromodomain Bound to Histone H3 Methylated at Lysine 9 Nature, 416, 2002

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