PDB: 5653 件ウェブページステータス検索Chemie searchBIRD

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5F33	Structure of quinolinate synthase in complex with phosphoglycolohydroxamate 分子名称: IRON/SULFUR CLUSTER, PHOSPHOGLYCOLOHYDROXAMIC ACID, Quinolinate synthase A, ... 著者 Volbeda, A, Fontecilla-Camps, J.C. 登録日 2015-12-02 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product. J.Am.Chem.Soc., 138, 2016
5F35	Structure of quinolinate synthase in complex with citrate 分子名称: CITRATE ANION, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... 著者 Volbeda, A, Fontecilla-Camps, J.C. 登録日 2015-12-02 公開日 2016-08-31 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product. J.Am.Chem.Soc., 138, 2016
3WK3	Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with orotidine 5'-monophosphate ethyl ester 分子名称: 6-(ethoxycarbonyl)uridine 5'-(dihydrogen phosphate), GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fujihashi, M, Pai, E.F, Miki, K. 登録日 2013-10-17 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
5F3D	Structure of quinolinate synthase in complex with reaction intermediate W 分子名称: 2-IMINO,3-CARBOXY,5-OXO,6-HYDROXY HEXANOIC ACID, IRON/SULFUR CLUSTER, Quinolinate synthase A, ... 著者 Volbeda, A, Fontecilla-Camps, J.C. 登録日 2015-12-02 公開日 2016-08-31 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product. J.Am.Chem.Soc., 138, 2016
3WK0	Wild-type orotidine 5'-monophosphate decarboxylase from M. thermoautotrophicus complexed with orotidine 5'-monophosphate methyl ester 分子名称: 6-(methoxycarbonyl)uridine 5'-(dihydrogen phosphate), GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fujihashi, M, Pai, E.F, Miki, K. 登録日 2013-10-17 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
6B8S	Crystal Structure of Dihydroorotate Dehydrogenase from Helicobacter pylori with bound FMN 分子名称: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, TRIETHYLENE GLYCOL 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-10-09 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal Structure of Dihydroorotate Dehydrogenase from Helicobacter pylori with bound FMN to be published
3WJW	Wild-type orotidine 5'-monophosphate decarboxylase from M. thermoautotrophicus complexed with 6-methyl-UMP 分子名称: 6-methyluridine 5'-(dihydrogen phosphate), Orotidine 5'-phosphate decarboxylase 著者 Fujihashi, M, Kuroda, S, Pai, E.F, Miki, K. 登録日 2013-10-17 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
3W7R	Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097 分子名称: 2,6-dioxo-5-[2-(4-phenylphenyl)ethyl]-1,2,3,6- tetrahydropyrimidine-4-carboxylic acid, ACETATE ION, CHLORIDE ION, ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2013-03-06 公開日 2014-03-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097 To be Published
3WJX	Wild-type orotidine 5'-monophosphate decarboxylase from M. thermoautotrophicus complexed with 6-amino-UMP 分子名称: 6-AMINOURIDINE 5'-MONOPHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fujihashi, M, Kuroda, S, Pai, E.F, Miki, K. 登録日 2013-10-17 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
3WJY	Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with 6-amino-UMP 分子名称: 6-AMINOURIDINE 5'-MONOPHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fujihashi, M, Pai, E.F, Miki, K. 登録日 2013-10-17 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
3WK1	Wild-type orotidine 5'-monophosphate decarboxylase from M. thermoautotrophicus complexed with orotidine 5'-monophosphate ethyl ester 分子名称: 6-(ethoxycarbonyl)uridine 5'-(dihydrogen phosphate), GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fujihashi, M, Pai, E.F, Miki, K. 登録日 2013-10-17 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
6ET4	HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ACETIC ACID, CHLORIDE ION, ... 著者 Hakansson, M, Walse, B, Gustavsson, A.-L, Lain, S. 登録日 2017-10-25 公開日 2018-03-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. Nat Commun, 9, 2018
3WJZ	Orotidine 5'-monophosphate decarboxylase D75N mutant from M. thermoautotrophicus complexed with 6-amino-UMP 分子名称: 6-AMINOURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, GLYCEROL, ... 著者 Fujihashi, M, Pai, E.F, Miki, K. 登録日 2013-10-17 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
3WK2	Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with orotidine 5'-monophosphate methyl ester 分子名称: 6-(methoxycarbonyl)uridine 5'-(dihydrogen phosphate), GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fujihashi, M, Pai, E.F, Miki, K. 登録日 2013-10-17 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
4IV5	X-ray crystal structure of a putative aspartate carbamoyltransferase from Trypanosoma cruzi 分子名称: 1,2-ETHANEDIOL, Aspartate carbamoyltransferase, putative, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-01-22 公開日 2013-04-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray crystal structure of a putative aspartate carbamoyltransferase from Trypanosoma cruzi TO BE PUBLISHED
6CJG	Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 46 分子名称: 2-([1,1'-biphenyl]-4-yl)-3-methyl-1,7-naphthyridine-4-carboxylic acid, 3-[decyl(dimethyl)ammonio]propane-1-sulfonate, Dihydroorotate dehydrogenase (quinone), ... 著者 Petrunak, E.M, Stuckey, J.A. 登録日 2018-02-26 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.851 Å) 主引用文献 Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase. J. Med. Chem., 61, 2018
6CJF	Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43 分子名称: 2-[4-(2-chloro-6-methylpyridin-3-yl)phenyl]-6-fluoro-3-methylquinoline-4-carboxylic acid, 3-[decyl(dimethyl)ammonio]propane-1-sulfonate, Dihydroorotate dehydrogenase (quinone), ... 著者 Petrunak, E.M, Stuckey, J.A. 登録日 2018-02-26 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase. J. Med. Chem., 61, 2018
2BE7	Crystal structure of the unliganded (T-state) aspartate transcarbamoylase of the psychrophilic bacterium Moritella profunda 分子名称: Aspartate Carbamoyltransferase Catalytic Chain, Aspartate Carbamoyltransferase Regulatory Chain, SULFATE ION, ... 著者 De Vos, D, Savvides, S.N, Van Beeumen, J. 登録日 2005-10-23 公開日 2006-10-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural investigation of cold activity and regulation of aspartate carbamoyltransferase from the extreme psychrophilic bacterium Moritella profunda. J.Mol.Biol., 365, 2007
2BE9	Crystal structure of the CTP-liganded (T-State) aspartate transcarbamoylase from the extremely thermophilic archaeon Sulfolobus acidocaldarius 分子名称: Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 De Vos, D, Savvides, S.N, Van Beeumen, J.J. 登録日 2005-10-23 公開日 2006-10-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of Sulfolobus acidocaldarius aspartate carbamoyltransferase in complex with its allosteric activator CTP. Biochem.Biophys.Res.Commun., 372, 2008
6GK0	HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH CLASS III HISTONE DEACETYLASE INHIBITOR 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 4-~{tert}-butyl-~{N}-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide, ACETIC ACID, ... 著者 Hakansson, M, Ladds, M.J.G.W, Walse, B, Lain, S. 登録日 2018-05-17 公開日 2019-11-27 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology. J.Biol.Chem., 295, 2020
4ZDK	Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with UTP, AMP-PCP and oxonorleucine 分子名称: 5-OXO-L-NORLEUCINE, CTP synthase, MAGNESIUM ION, ... 著者 Bellinzoni, M, Barilone, N, Alzari, P.M. 登録日 2015-04-17 公開日 2015-07-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.49 Å) 主引用文献 Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015
4AT1	STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ... 著者 Stevens, R.C, Gouaux, J.E, Lipscomb, W.N. 登録日 1990-04-26 公開日 1990-10-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution. Biochemistry, 29, 1990
4BJH	Crystal Structure of the Aquifex Reactor Complex Formed by Dihydroorotase (H180A, H232A) with Dihydroorotate and Aspartate Transcarbamoylase with N-(phosphonacetyl)-L-aspartate (PALA) 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 1,2-ETHANEDIOL, ASPARTATE CARBAMOYLTRANSFERASE, ... 著者 Edwards, B.F.P, Martin, P.D, Grimley, E, Vaishnav, A, Fernando, R, Brunzelle, J.S, Cordes, M, Evans, H.G, Evans, D.R. 登録日 2013-04-18 公開日 2013-12-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The Mononuclear Metal Center of Type-I Dihydroorotase from Aquifex Aeolicus. Bmc Biochem., 14, 2013
5DOT	Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form 分子名称: 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ... 著者 Polo, L.M, de Cima, S, Fita, I, Rubio, V. 登録日 2015-09-11 公開日 2015-12-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
4ZDJ	Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with two UTP molecules 分子名称: CTP synthase, GLYCEROL, MAGNESIUM ION, ... 著者 Bellinzoni, M, Barilone, N, Alzari, P.M. 登録日 2015-04-17 公開日 2015-07-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015

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