PDB: 5653 件ウェブページステータス検索Chemie searchBIRD

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8WKR	Crystal structure of O-acetylhomoserine sulfhydrylase from Lactobacillus plantarum in the open form 分子名称: (2S)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid, L-methionine gamma-lyase, PROLINE 著者 Oda, K, Matoba, Y. 登録日 2023-09-28 公開日 2024-02-14 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 pH-dependent regulation of an acidophilic O -acetylhomoserine sulfhydrylase from Lactobacillus plantarum. Appl.Environ.Microbiol., 90, 2024
8UXI	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... 著者 Miotto, M.C, Marks, A.R. 登録日 2023-11-09 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.29 Å) 主引用文献 Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXE	Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 分子名称: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... 著者 Miotto, M.C, Marks, A.R. 登録日 2023-11-09 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8X6P	Isomerase Protein 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP1A, SULFATE ION 著者 Guven, O, Demirci, H. 登録日 2023-11-21 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Isomerase Protein To Be Published
8UXC	Structure of PKA phosphorylated human RyR2-R420Q in the primed state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... 著者 Miotto, M.C, Marks, A.R. 登録日 2023-11-09 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXG	Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 分子名称: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... 著者 Miotto, M.C, Marks, A.R. 登録日 2023-11-09 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXH	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... 著者 Miotto, M.C, Marks, A.R. 登録日 2023-11-09 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.52 Å) 主引用文献 Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
7Q1H	Variant D312N of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the substrate OMP at 1.31 Angstrom resolution 分子名称: OROTIDINE-5'-MONOPHOSPHATE, PROLINE, SULFATE ION, ... 著者 Rabe von Pappenheim, F, Kirck, L.L. 登録日 2021-10-20 公開日 2022-05-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
8AT1	CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H 分子名称: ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ... 著者 Gouaux, J.E, Stevens, R.C, Lipscomb, W.N. 登録日 1989-09-22 公開日 1990-10-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH. Biochemistry, 29, 1990
6VND	Quaternary Complex of human dihydroorotate dehydrogenase (DHODH) with flavin mononucleotide (FMN), orotic acid and AG-636 分子名称: 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-1H-benzotriazole-7-carboxylic acid, ACETATE ION, CHLORIDE ION, ... 著者 Padyana, A, Jin, L. 登録日 2020-01-29 公開日 2020-11-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol.Cancer Ther., 19, 2020
7P4M	Structure of the quinolinate synthase Y107F variant in an empty open form 分子名称: CHLORIDE ION, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, ... 著者 Volbeda, A. 登録日 2021-07-12 公開日 2021-09-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Transient Formation of a Second Active Site Cavity during Quinolinic Acid Synthesis by NadA. Acs Chem.Biol., 16, 2021
7P4Q	Structure of the quinolinate synthase S124A variant complexed with citrate 分子名称: CHLORIDE ION, CITRATE ANION, FE3-S4 CLUSTER, ... 著者 Volbeda, A. 登録日 2021-07-12 公開日 2021-09-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Transient Formation of a Second Active Site Cavity during Quinolinic Acid Synthesis by NadA. Acs Chem.Biol., 16, 2021
7P4P	Structure of the quinolinate synthase A84L variant complexed with citrate 分子名称: CHLORIDE ION, CITRATE ANION, IRON/SULFUR CLUSTER, ... 著者 Volbeda, A. 登録日 2021-07-12 公開日 2021-09-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Transient Formation of a Second Active Site Cavity during Quinolinic Acid Synthesis by NadA. Acs Chem.Biol., 16, 2021
6HL7	Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with mutated active site (R109A/K138A) and N-carbamoyl-L-phosphate bound 分子名称: Aspartate transcarbamoylase, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER 著者 Bosch, S.S, Lunev, S, Wrenger, C, Groves, M.R. 登録日 2018-09-10 公開日 2018-09-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular Target Validation of Aspartate Transcarbamoylase fromPlasmodium falciparumby Torin 2. Acs Infect Dis., 6, 2020
6ZWZ	Resting state structure of the OMPD-domain of human UMPS variant (K314AcK) at 1.2 Angstroms resolution 分子名称: SULFATE ION, Uridine 5'-monophosphate synthase 著者 Tittmann, K, Rindfleisch, S, Krull, M. 登録日 2020-07-29 公開日 2022-02-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
6ZX1	OMPD-domain of human UMPS in complex with 6-Aza-UMP at 1.0 Angstroms resolution 分子名称: 6-AZA URIDINE 5'-MONOPHOSPHATE, PROLINE, SULFATE ION, ... 著者 Tittmann, K, Rindfleisch, S, Krull, M. 登録日 2020-07-29 公開日 2022-02-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
6ZWY	OMPD-domain of human UMPS in complex with UMP at 1.0 Angstroms resolution 分子名称: GLYCEROL, PROLINE, URIDINE-5'-MONOPHOSPHATE, ... 著者 Tittmann, K, Rindfleisch, S. 登録日 2020-07-29 公開日 2022-02-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
6ZX3	OMPD-domain of human UMPS in complex with 6-thiocarboxamido-UMP at 1.15 Angstroms resolution 分子名称: GLYCEROL, PROLINE, SULFATE ION, ... 著者 Tittmann, K, Rindfleisch, S, Schimdt, T. 登録日 2020-07-29 公開日 2022-02-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
6ZX0	OMPD-domain of human UMPS in complex with the substrate OMP at 1.25 Angstroms resolution 分子名称: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... 著者 Tittmann, K, Rindfleisch, S, Krull, M. 登録日 2020-07-29 公開日 2022-02-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
6ZX2	OMPD-domain of human UMPS in complex with 6-carboxamido-UMP at 1.2 Angstroms resolution 分子名称: PROLINE, SULFATE ION, Uridine 5'-monophosphate synthase, ... 著者 Tittmann, K, Rindfleisch, S, Schimdt, T. 登録日 2020-07-29 公開日 2022-02-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
4MX2	Crystal Structure of adenylosuccinate lyase from Leishmania donovani 分子名称: ADENOSINE MONOPHOSPHATE, Adenylosuccinate lyase, GLYCEROL, ... 著者 Wernimont, A.K, Loppnau, P, Dong, A, Krojer, T, Bradley, A, Bushell, S, von Delft, F, Robinson, D, Gilbert, I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Hui, R, Mottaghi, K, Structural Genomics Consortium (SGC) 登録日 2013-09-25 公開日 2014-04-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of adenylosuccinate lyase from Leishmania donovani To be Published
8CSO	Crystal Structure of Orotidine 5'-phosphate decarboxylase from Klebsiella pneumoniae in complex with Uridine-5'-monophosphate 分子名称: 1,2-ETHANEDIOL, Orotidine 5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-05-13 公開日 2022-06-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of Orotidine 5'-phosphate decarboxylase from Klebsiella pneumoniae in complex with Guanosine-5'-monophosphate to be published
3VE7	Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula complexed with inhibitor BMP 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, ACETIC ACID, Orotidine-5'-phosphate decarboxylase, ... 著者 Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. 登録日 2012-01-07 公開日 2013-01-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.539 Å) 主引用文献 Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula complexed with inhibitor BMP To be Published
6LKE	in meso full-length rat KMO in complex with an inhibitor identified via DNA-encoded chemical library screening 分子名称: 4-chloranyl-2-[[5-chloranyl-2-(5-methoxy-1,3-dihydroisoindol-2-yl)-1,3-thiazol-4-yl]carbonyl-methyl-amino]-5-fluoranyl-benzoic acid, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Mimasu, S, Yamagishi, H, Kiyohara, M, Hupp, D.C, Liu, J, Kakefuda, K, Okuda, T. 登録日 2019-12-19 公開日 2020-12-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition. Commun Biol, 4, 2021
6AT1	STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION 分子名称: ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ... 著者 Stevens, R.C, Gouaux, J.E, Lipscomb, W.N. 登録日 1990-04-26 公開日 1990-10-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution. Biochemistry, 29, 1990

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