PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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3ASM	Crystal structure of Q54A mutant protein of Bst-RNase HIII 分子名称: Ribonuclease HIII 著者 Angkawidjaja, C, Kanaya, S. 登録日 2010-12-16 公開日 2011-06-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.603 Å) 主引用文献 Identification of the substrate binding site in the N-terminal TBP-like domain of RNase H3. Febs Lett., 585, 2011
4JCJ	Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain 分子名称: Insulin gene enhancer protein ISL-1,LIM domain-binding protein 1, ZINC ION 著者 Gadd, M.S, Jacques, D.A, Guss, J.M, Matthews, J.M. 登録日 2013-02-21 公開日 2013-06-19 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions. J.Biol.Chem., 288, 2013
3KLI	Crystal structure of unliganded AZT-resistant HIV-1 Reverse Transcriptase 分子名称: Reverse transcriptase/ribonuclease H, p51 RT 著者 Tu, X, Sarafianos, S.G, Arnold, E. 登録日 2009-11-08 公開日 2010-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural basis of HIV-1 resistance to AZT by excision. Nat.Struct.Mol.Biol., 17, 2010
2PY9	Protein-RNA Interaction involving KH1 domain from Human Poly(C)-Binding Protein-2 分子名称: 12-mer C-rich strand of human telomeric RNA, Poly(rC)-binding protein 2 著者 James, T.L, Du, Z, Lee, J.K. 登録日 2007-05-15 公開日 2007-06-12 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. Rna, 13, 2007
2HX0	Three-dimensional structure of the hypothetical protein from Salmonella cholerae-suis (aka Salmonella enterica) at the resolution 1.55 A. Northeast Structural Genomics target ScR59. 分子名称: MAGNESIUM ION, Putative DNA-binding protein 著者 Kuzin, A.P, Abashidze, M, Seetharaman, J, Shastry, R, Conover, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2006-08-02 公開日 2006-09-19 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Three-dimensional structure of the hypothetical protein from Salmonella cholerae-suis (aka Salmonella enterica) at the resolution 1.55 A. Northeast Structural Genomics target ScR59. To be Published
4EOM	Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. 登録日 2012-04-14 公開日 2013-02-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
4EOP	Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306 分子名称: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. 登録日 2012-04-14 公開日 2013-02-06 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
4EOJ	Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. 登録日 2012-04-14 公開日 2013-02-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
3BZJ	UVDE K229L 分子名称: MANGANESE (II) ION, SULFATE ION, UV endonuclease 著者 Meulenbroek, E.M, Paspaleva, K, Thomassen, E.A.J, Abrahams, J.P, Goosen, N, Pannu, N.S. 登録日 2008-01-18 公開日 2008-12-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Involvement of a carboxylated lysine in UV damage endonuclease Protein Sci., 18, 2009
3C0Q	UVDE E175A 分子名称: MANGANESE (II) ION, SULFATE ION, UV endonuclease 著者 Meulenbroek, E.M, Paspaleva, K, Thomassen, E.A.J, Abrahams, J.P, Goosen, N, Pannu, N.S. 登録日 2008-01-21 公開日 2008-12-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Involvement of a carboxylated lysine in UV damage endonuclease Protein Sci., 18, 2009
4EOK	Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102 分子名称: Cyclin-A2, Cyclin-dependent kinase 2, MONOTHIOGLYCEROL, ... 著者 Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. 登録日 2012-04-14 公開日 2013-02-06 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
4EOS	Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306 分子名称: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2 著者 Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. 登録日 2012-04-14 公開日 2013-02-06 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
2L8B	TraI (381-569) 分子名称: Protein traI 著者 Wright, N.T, Raththagala, M.U, Edwards, S, Krueger, S, Schildbach, J.F. 登録日 2011-01-07 公開日 2012-01-11 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structure and small angle scattering analysis of TraI (381-569). Proteins, 80, 2012
3PLW	Ref protein from P1 bacteriophage 分子名称: Recombination enhancement function protein, SULFATE ION, ZINC ION 著者 Keck, J.L, Lu, D, Cox, M.M. 登録日 2010-11-15 公開日 2010-12-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Creating Directed Double-strand Breaks with the Ref Protein: A NOVEL RecA-DEPENDENT NUCLEASE FROM BACTERIOPHAGE P1. J.Biol.Chem., 286, 2011
2MO0	Backbone 1H, 13C, and 15N Chemical Shift Assignments for cold shock protein, TaCsp 分子名称: Cold-shock DNA-binding domain protein 著者 Jin, B, Jeong, K.W, Kim, Y. 登録日 2014-04-17 公開日 2014-08-20 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structure and flexibility of the thermophilic cold-shock protein of Thermus aquaticus. Biochem.Biophys.Res.Commun., 451, 2014
8BU4	Structure of DDB1 bound to DS22-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUJ	Structure of DDB1 bound to DS06-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.62 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU6	Structure of DDB1 bound to DS55-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU9	Structure of DDB1 bound to roscovitine-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.51 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUK	Structure of DDB1 bound to DS08-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, CITRIC ACID, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUP	Structure of DDB1 bound to DS30-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU3	Structure of DDB1 bound to DS19-engaged CDK12-cyclin K 分子名称: 1,2-ETHANEDIOL, 2-morpholin-4-yl-9-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]purin-6-amine, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUB	Structure of DDB1 bound to dCeMM4-engaged CDK12-cyclin K 分子名称: CITRIC ACID, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUQ	Structure of DDB1 bound to DS43-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[[1-(3-chlorophenyl)pyrazol-3-yl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, CITRIC ACID, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUL	Structure of DDB1 bound to DS11-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024

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