3ASM
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4JCJ
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![BU of 4jcj by Molmil](/molmil-images/mine/4jcj) | Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain | 分子名称: | Insulin gene enhancer protein ISL-1,LIM domain-binding protein 1, ZINC ION | 著者 | Gadd, M.S, Jacques, D.A, Guss, J.M, Matthews, J.M. | 登録日 | 2013-02-21 | 公開日 | 2013-06-19 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions. J.Biol.Chem., 288, 2013
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3KLI
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2PY9
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2HX0
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![BU of 2hx0 by Molmil](/molmil-images/mine/2hx0) | Three-dimensional structure of the hypothetical protein from Salmonella cholerae-suis (aka Salmonella enterica) at the resolution 1.55 A. Northeast Structural Genomics target ScR59. | 分子名称: | MAGNESIUM ION, Putative DNA-binding protein | 著者 | Kuzin, A.P, Abashidze, M, Seetharaman, J, Shastry, R, Conover, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-08-02 | 公開日 | 2006-09-19 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Three-dimensional structure of the hypothetical protein from Salmonella cholerae-suis (aka Salmonella enterica) at the resolution 1.55 A. Northeast Structural Genomics target ScR59. To be Published
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4EOM
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![BU of 4eom by Molmil](/molmil-images/mine/4eom) | Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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4EOP
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![BU of 4eop by Molmil](/molmil-images/mine/4eop) | Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306 | 分子名称: | (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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4EOJ
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![BU of 4eoj by Molmil](/molmil-images/mine/4eoj) | Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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3BZJ
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![BU of 3bzj by Molmil](/molmil-images/mine/3bzj) | UVDE K229L | 分子名称: | MANGANESE (II) ION, SULFATE ION, UV endonuclease | 著者 | Meulenbroek, E.M, Paspaleva, K, Thomassen, E.A.J, Abrahams, J.P, Goosen, N, Pannu, N.S. | 登録日 | 2008-01-18 | 公開日 | 2008-12-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Involvement of a carboxylated lysine in UV damage endonuclease Protein Sci., 18, 2009
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3C0Q
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![BU of 3c0q by Molmil](/molmil-images/mine/3c0q) | UVDE E175A | 分子名称: | MANGANESE (II) ION, SULFATE ION, UV endonuclease | 著者 | Meulenbroek, E.M, Paspaleva, K, Thomassen, E.A.J, Abrahams, J.P, Goosen, N, Pannu, N.S. | 登録日 | 2008-01-21 | 公開日 | 2008-12-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Involvement of a carboxylated lysine in UV damage endonuclease Protein Sci., 18, 2009
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4EOK
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![BU of 4eok by Molmil](/molmil-images/mine/4eok) | Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102 | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2, MONOTHIOGLYCEROL, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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4EOS
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![BU of 4eos by Molmil](/molmil-images/mine/4eos) | Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306 | 分子名称: | (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2 | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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2L8B
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![BU of 2l8b by Molmil](/molmil-images/mine/2l8b) | TraI (381-569) | 分子名称: | Protein traI | 著者 | Wright, N.T, Raththagala, M.U, Edwards, S, Krueger, S, Schildbach, J.F. | 登録日 | 2011-01-07 | 公開日 | 2012-01-11 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and small angle scattering analysis of TraI (381-569). Proteins, 80, 2012
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3PLW
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![BU of 3plw by Molmil](/molmil-images/mine/3plw) | Ref protein from P1 bacteriophage | 分子名称: | Recombination enhancement function protein, SULFATE ION, ZINC ION | 著者 | Keck, J.L, Lu, D, Cox, M.M. | 登録日 | 2010-11-15 | 公開日 | 2010-12-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Creating Directed Double-strand Breaks with the Ref Protein: A NOVEL RecA-DEPENDENT NUCLEASE FROM BACTERIOPHAGE P1. J.Biol.Chem., 286, 2011
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2MO0
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![BU of 2mo0 by Molmil](/molmil-images/mine/2mo0) | Backbone 1H, 13C, and 15N Chemical Shift Assignments for cold shock protein, TaCsp | 分子名称: | Cold-shock DNA-binding domain protein | 著者 | Jin, B, Jeong, K.W, Kim, Y. | 登録日 | 2014-04-17 | 公開日 | 2014-08-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and flexibility of the thermophilic cold-shock protein of Thermus aquaticus. Biochem.Biophys.Res.Commun., 451, 2014
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8BU4
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![BU of 8bu4 by Molmil](/molmil-images/mine/8bu4) | Structure of DDB1 bound to DS22-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUJ
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![BU of 8buj by Molmil](/molmil-images/mine/8buj) | Structure of DDB1 bound to DS06-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.62 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU6
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![BU of 8bu6 by Molmil](/molmil-images/mine/8bu6) | Structure of DDB1 bound to DS55-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU9
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![BU of 8bu9 by Molmil](/molmil-images/mine/8bu9) | Structure of DDB1 bound to roscovitine-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.51 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUK
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![BU of 8buk by Molmil](/molmil-images/mine/8buk) | Structure of DDB1 bound to DS08-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, CITRIC ACID, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUP
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![BU of 8bup by Molmil](/molmil-images/mine/8bup) | Structure of DDB1 bound to DS30-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU3
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![BU of 8bu3 by Molmil](/molmil-images/mine/8bu3) | Structure of DDB1 bound to DS19-engaged CDK12-cyclin K | 分子名称: | 1,2-ETHANEDIOL, 2-morpholin-4-yl-9-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]purin-6-amine, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUB
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![BU of 8bub by Molmil](/molmil-images/mine/8bub) | Structure of DDB1 bound to dCeMM4-engaged CDK12-cyclin K | 分子名称: | CITRIC ACID, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUQ
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![BU of 8buq by Molmil](/molmil-images/mine/8buq) | Structure of DDB1 bound to DS43-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-[[1-(3-chlorophenyl)pyrazol-3-yl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, CITRIC ACID, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUL
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![BU of 8bul by Molmil](/molmil-images/mine/8bul) | Structure of DDB1 bound to DS11-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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