2VH0
| Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs | 分子名称: | 2-(5-chlorothiophen-2-yl)-N-[(3S)-1-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-2-oxopyrrolidin-3-yl]ethanesulfonamide, ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN, ... | 著者 | Young, R.J, Borthwick, A.D, Brown, D, Burns-Kurtis, C.L, Campbell, M, Chan, C, Charbaut, M, Convery, M.A, Diallo, H, Hortense, E, Irving, W.R, Kelly, H.A, King, N.P, Kleanthous, S, Mason, A.M, Pateman, A.J, Patikis, A, Pinto, I.L, Pollard, D.R, Senger, S, Shah, G.P, Toomey, J.R, Watson, N.S, Weston, H.E, Zhou, P. | 登録日 | 2007-11-16 | 公開日 | 2008-11-25 | 最終更新日 | 2019-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs. Bioorg. Med. Chem. Lett., 18, 2008
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4CAU
| THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH 2 HMAB 14C10 FAB | 分子名称: | ENVELOPE PROTEIN E, FAB 14C10 | 著者 | Teoh, E.P, Kukkaro, P, Teo, E.W, Lim, A.P, Tan, T.T, Yip, A, Schul, W, Aung, M, Kostyuchenko, V.A, Leo, Y.S, Chan, S.H, Smith, K.G, Chan, A.H, Zou, G, Ooi, E.E, Kemeny, D.M, Tan, G.K, Ng, J.K, Ng, M.L, Alonso, S, Fisher, D, Shi, P.Y, Hanson, B.J, Lok, S.M, Macary, P.A. | 登録日 | 2013-10-09 | 公開日 | 2013-10-16 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | The Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Human Antibody. Sci.Trans.Med, 4, 2012
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4C2P
| Crystal structure of human testis angiotensin-I converting enzyme mutant R522K in complex with captopril | 分子名称: | ACETATE ION, ANGIOTENSIN-CONVERTING ENZYME, CHLORIDE ION, ... | 著者 | Masuyer, G, Yates, C.J, Schwager, S.L.U, Mohd, A, Sturrock, E.D, Acharya, K.R. | 登録日 | 2013-08-19 | 公開日 | 2013-12-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Molecular and Thermodynamic Mechanisms of the Chloride Dependent Human Angiotensin-I Converting Enzyme (Ace) J.Biol.Chem., 289, 2014
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3TR1
| Structure of a 3-phosphoshikimate 1-carboxyvinyltransferase (aroA) from Coxiella burnetii | 分子名称: | 3-phosphoshikimate 1-carboxyvinyltransferase, PHOSPHATE ION, POTASSIUM ION | 著者 | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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4C2Q
| Crystal structure of human testis angiotensin-I converting enzyme mutant R522K | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ACETATE ION, ANGIOTENSIN-CONVERTING ENZYME, ... | 著者 | Masuyer, G, Yates, C.J, Schwager, S.L.U, Mohd, A, Sturrock, E.D, Acharya, K.R. | 登録日 | 2013-08-19 | 公開日 | 2013-12-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular and Thermodynamic Mechanisms of the Chloride Dependent Human Angiotensin-I Converting Enzyme (Ace) J.Biol.Chem., 289, 2014
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4C2N
| Crystal structure of human testis angiotensin-I converting enzyme mutant E403R | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ANGIOTENSIN-CONVERTING ENZYME, CHLORIDE ION, ... | 著者 | Masuyer, G, Yates, C.J, Schwager, S.L.U, Mohd, A, Sturrock, E.D, Acharya, K.R. | 登録日 | 2013-08-19 | 公開日 | 2013-12-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Molecular and Thermodynamic Mechanisms of the Chloride Dependent Human Angiotensin-I Converting Enzyme (Ace) J.Biol.Chem., 289, 2014
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1EXD
| CRYSTAL STRUCTURE OF A TIGHT-BINDING GLUTAMINE TRNA BOUND TO GLUTAMINE AMINOACYL TRNA SYNTHETASE | 分子名称: | ADENOSINE MONOPHOSPHATE, GLUTAMINE TRNA APTAMER, GLUTAMINYL-TRNA SYNTHETASE, ... | 著者 | Bullock, T.L, Sherlin, L.D, Perona, J.J. | 登録日 | 2000-05-02 | 公開日 | 2000-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Tertiary core rearrangements in a tight binding transfer RNA aptamer. Nat.Struct.Biol., 7, 2000
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4C2R
| Crystal structure of human testis angiotensin-I converting enzyme mutant R522Q | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ACETATE ION, ANGIOTENSIN-CONVERTING ENZYME, ... | 著者 | Masuyer, G, Yates, C.J, Schwager, S.L.U, Mohd, A, Sturrock, E.D, Acharya, K.R. | 登録日 | 2013-08-19 | 公開日 | 2013-12-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular and Thermodynamic Mechanisms of the Chloride Dependent Human Angiotensin-I Converting Enzyme (Ace) J.Biol.Chem., 289, 2014
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4NG4
| Structure of phosphoglycerate kinase (CBU_1782) from Coxiella burnetii | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoglycerate kinase | 著者 | Franklin, M.C, Cheung, J, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2013-11-01 | 公開日 | 2015-06-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3WA1
| Crystal structure of BinB: A receptor binding component of the binary toxin from Lysinibacillus sphaericus | 分子名称: | BinB protein | 著者 | Srisucharitpanit, K, Yao, M, Chimnaronk, S, Promdonkoy, B, Boonserm, P, Tanaka, I. | 登録日 | 2013-04-22 | 公開日 | 2014-07-02 | 最終更新日 | 2014-10-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of BinB: A receptor binding component of the binary toxin from Lysinibacillus sphaericus Proteins, 82, 2014
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4CW4
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1K2I
| Crystal Structure of Gamma-Chymotrypsin in Complex with 7-Hydroxycoumarin | 分子名称: | 2,4-DIHYDROXY-TRANS CINNAMIC ACID, CHYMOTRYPSINOGEN A, SULFATE ION | 著者 | Ghani, U, Ng, K.K.S, Atta-ur-Rahman, Choudhary, M.I, Ullah, N, James, M.N.G. | 登録日 | 2001-09-27 | 公開日 | 2001-12-05 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of gamma-chymotrypsin in complex with 7-hydroxycoumarin. J.Mol.Biol., 314, 2001
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3T0V
| Unliganded fluorogen activating protein M8VL | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, ... | 著者 | Stanfield, R, Senutovitch, N, Bhattacharyya, S, Rule, G, Wilson, I.A, Armitage, B, Waggoner, A.S, Berget, P. | 登録日 | 2011-07-20 | 公開日 | 2012-03-21 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | 主引用文献 | A variable light domain fluorogen activating protein homodimerizes to activate dimethylindole red. Biochemistry, 51, 2012
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3TQW
| Structure of a ABC transporter, periplasmic substrate-binding protein from Coxiella burnetii | 分子名称: | METHIONINE, Methionine-binding protein, SULFATE ION | 著者 | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-21 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TRC
| Structure of the GAF domain from a phosphoenolpyruvate-protein phosphotransferase (ptsP) from Coxiella burnetii | 分子名称: | PHOSPHATE ION, Phosphoenolpyruvate-protein phosphotransferase, SODIUM ION | 著者 | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TQL
| Structure of the amino acid ABC transporter, periplasmic amino acid-binding protein from Coxiella burnetii. | 分子名称: | ARGININE, Arginine-binding protein, IMIDAZOLE | 著者 | Rudolph, M, Cheung, J, Franklin, M.C, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-10-05 | 最終更新日 | 2016-01-20 | 実験手法 | X-RAY DIFFRACTION (1.594 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TQR
| Structure of the phosphoribosylglycinamide formyltransferase (purN) in complex with CHES from Coxiella burnetii | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CHLORIDE ION, Phosphoribosylglycinamide formyltransferase | 著者 | Rudolph, M, Cheung, J, Franklin, M.C, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TR2
| Structure of a orotidine 5'-phosphate decarboxylase (pyrF) from Coxiella burnetii | 分子名称: | Orotidine 5'-phosphate decarboxylase | 著者 | Cheung, J, Franklin, M, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-21 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TRH
| Structure of a phosphoribosylaminoimidazole carboxylase catalytic subunit (purE) from Coxiella burnetii | 分子名称: | Phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit | 著者 | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TQI
| Structure of the GMP synthase (guaA) from Coxiella burnetii | 分子名称: | GMP synthase [glutamine-hydrolyzing] | 著者 | Franklin, M.C, Cheung, J, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TQX
| Structure of the 2-amino-3-ketobutyrate coenzyme A ligase (kbl) from Coxiella burnetii | 分子名称: | 2-amino-3-ketobutyrate coenzyme A ligase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-21 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.304 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TRD
| Structure of an alpha-beta serine hydrolase homologue from Coxiella burnetii | 分子名称: | ACETATE ION, Alpha/beta hydrolase, PHOSPHATE ION, ... | 著者 | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TQG
| Structure of the 2-methylcitrate synthase (prpC) from Coxiella burnetii | 分子名称: | 2-methylcitrate synthase | 著者 | Franklin, M.C, Cheung, J, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TR5
| Structure of a peptide chain release factor 3 (prfC) from Coxiella burnetii | 分子名称: | CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Peptide chain release factor 3 | 著者 | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3U2O
| Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor | 分子名称: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Lozoya, E, Segarra, V, Erra, M, Wenzkowski, C, Jestel, A, Krapp, S, Blaesse, M. | 登録日 | 2011-10-04 | 公開日 | 2011-11-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Biaryl analogues of teriflunomide as potent DHODH inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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